Genetic determinants of plasma triglycerides: impact of rare and common mutations.

abstract：:Despite the recent decline in mortality from coronary heart disease (CHD), this disease remains the leading killer of US adults of all ages. CHD in young adults is not as well characterized as CHD in older individuals because it occurs less frequently, but this disease can have devastating consequences for young patie...

journal_title：Current atherosclerosis reports

authors： Rubin JB,Borden WB

更新日期：2012-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Coronary artery disease (CAD) is a major cause of morbidity and mortality globally and poses a threat to both men and women across their lifespans. There is accumulating evidence to support that CAD may present differently in women and men, ranging from the clinical presentation, diagnosis, and manage...

journal_title：Current atherosclerosis reports

authors： Madan N,Gajo E,Sanghani RM,Volgman AS

更新日期：2020-06-23 00:00:00

abstract：:Atherothrombosis remains a major cause of morbidity and mortality in the western world. The underlying processes associated with clinical expression of atherothrombosis include oxidative stress and proteolysis in relation to neovascularisation and intraplaque hemorrhages, leading to immuno-inflammatory response, cell ...

journal_title：Current atherosclerosis reports

authors： Martinez-Pinna R,Barbas C,Blanco-Colio LM,Tunon J,Ramos-Mozo P,Lopez JA,Meilhac O,Michel JB,Egido J,Martin-Ventura JL

更新日期：2010-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Studies have revealed a relation between birth weight (BW) and later risk of cardiovascular diseases (CVDs). This meta-analysis aimed to report the dose-response relationship between BW and risk of CVDs. RECENT FINDINGS:The relation of BW to CVD subtypes was found to be U-shaped as BW below ~ 2500 g ...

journal_title：Current atherosclerosis reports

authors： Mohseni R,Mohammed SH,Safabakhsh M,Mohseni F,Monfared ZS,Seyyedi J,Mejareh ZN,Alizadeh S

更新日期：2020-04-23 00:00:00

abstract：PURPOSE OF REVIEW:This review aims to explore the relationship between AF and carotid atherosclerosis, and the impact on the outcomes of cardiovascular and cerebrovascular events. Also, our aim is to critically review current knowledge and delineate future directions for effective treatment or prevention as well as str...

journal_title：Current atherosclerosis reports

authors： Wang Z,Korantzopoulos P,Liu T

更新日期：2019-11-29 00:00:00

abstract：:Recent randomized trials of hormone replacement therapy (HRT) in postmenopausal women are not consistent with the decrease in cardiovascular risk seen in observational studies of hormone therapy users compared with nonusers. Emerging evidence indicates that HRT use in some women with established coronary heart disease...

journal_title：Current atherosclerosis reports

authors： Duvernoy CS,Mosca L

更新日期：2002-03-01 00:00:00

abstract：:We briefly and comprehensively present some of the novel findings in the field of revascularization therapy and management of ST-segment-elevation myocardial infarction (STEMI). We highlight the latest evidence-based advancements in the pharmacological and mechanical treatment of patients who presented with STEMI. Sin...

journal_title：Current atherosclerosis reports

authors： Prodanov P,Widimsky P

更新日期：2014-06-01 00:00:00

abstract：:At a time when the lipid management guidelines give more and more emphasis to the identification and treatment of high-risk patients with the metabolic syndrome and diabetes, there is an obvious need to balance the known effects of low-density lipoprotein (LDL) lowering with the new evidence of clinical efficacy deriv...

journal_title：Current atherosclerosis reports

authors： Fazio S,Linton MF

更新日期：2004-03-01 00:00:00

abstract：:Paradoxical embolism through a patent foramen ovale (PFO) is a commonly identified potential mechanism of ischemic stroke, especially in young patients. The recurrent stroke rate among young cryptogenic stroke patients with a PFO is modest, but higher than normal for their age. Co-existing atrial septal aneurysm is a ...

journal_title：Current atherosclerosis reports

authors： Saver JL

更新日期：2007-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Non-alcoholic fatty liver disease (NAFLD) is frequently associated with obesity and overweight. It has a broad spectrum of clinical and histological presentations, such as steatosis, inflammation (known as non-alcoholic steatohepatitis or NASH), fibrosis, and cirrhosis. There is increasing evidence th...

journal_title：Current atherosclerosis reports

authors： Caravatto PP,Cohen R

更新日期：2017-10-07 00:00:00

abstract：:Managing dyslipidemia is an important part of the primary and secondary prevention of coronary heart disease. Low-density lipoprotein cholesterol reduction remains the primary lipid goal. Patients who have experienced an acute coronary syndrome (ACS) are at very high risk of recurrent adverse cardiovascular events. A ...

journal_title：Current atherosclerosis reports

authors： Polsani VR,Virani SS,Nambi V

更新日期：2009-03-01 00:00:00

abstract：:Effective prevention of the current annual $400 billion losses from atherosclerosis and cardiovascular disease (CVD) will require preventing primary causes rather than just decreasing signs and symptoms (risk factors) produced by those causes. All CVD risk factors predict a likelihood of CVD, but not all are causes of...

journal_title：Current atherosclerosis reports

authors： Lands B

更新日期：2009-07-01 00:00:00

abstract：:Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an enzyme which binds to oxidized LDL and has a pro-inflammatory role in the pathogenesis of atherosclerosis. The Lp-PLA(2) Studies Collaboration showed the relationship between Lp-PLA(2) levels and activity with coronary heart disease and ischemic stroke. Level...

journal_title：Current atherosclerosis reports

authors： Wong CK,White HD

更新日期：2011-12-01 00:00:00

abstract：:A substantial body of epidemiologic data has shed light on the potential protective effects of the Mediterranean diet against atherosclerosis in humans. Many believe the reason the Mediterranean diet is atheroprotective is the elevated consumption of olive oil, an oil poor in saturated fatty acids (SFA) and highly enr...

journal_title：Current atherosclerosis reports

authors： Brown JM,Shelness GS,Rudel LL

更新日期：2007-12-01 00:00:00

abstract：:Stroke is a common and disabling condition. Intravenous tissue plasminogen activator (tPA) administered within 3 h of symptom onset is the standard therapy for eligible patients with acute ischemic stroke. Unfortunately, because of the time limitation, very few patients with ischemic stroke actually receive this treat...

journal_title：Current atherosclerosis reports

authors： Elijovich L,Chong JY

更新日期：2010-09-01 00:00:00

abstract：:Daily lifestyle practices and habits profoundly affect the likelihood of developing cardiovascular disease (CVD). Abundant research and multiple recent consensus documents support the role of regular physical activity, not smoking cigarettes, maintaining a healthy body weight, controlling cholesterol levels, and contr...

journal_title：Current atherosclerosis reports

authors： Rippe JM,Angelopoulos TJ

更新日期：2014-10-01 00:00:00

abstract：:High-density lipoprotein cholesterol (HDL-C) levels are inversely related to risk of atherosclerotic cardiovascular disease (ASCVD). However, the simplistic assumption that HDL-C levels directly and causally impact atherogenesis has been challenged in recent years. The purpose of this article is to review the current ...

journal_title：Current atherosclerosis reports

authors： Brunham LR

更新日期：2016-12-01 00:00:00

abstract：:Approximately one third of ischemic strokes are labeled cryptogenic because the etiology is unknown despite a thorough evaluation. Paroxysmal atrial fibrillation carries the same risk of ischemic stroke as persistent atrial fibrillation and has increasingly gained attention as a potential source of cryptogenic stroke....

journal_title：Current atherosclerosis reports

authors： Zhang C,Kasner SE

更新日期：2015-12-01 00:00:00

abstract：:While the function of vitamin D in regulating calcium homeostasis is well established, there has been growing interest in its role in the prevention of numerous chronic diseases, including cardiovascular disease (CVD). There is mounting epidemiological evidence suggesting that vitamin D deficiency is linked to increas...

journal_title：Current atherosclerosis reports

authors： Chin K,Appel LJ,Michos ED

更新日期：2017-01-01 00:00:00

abstract：PURPOSE OF THE REVIEW:Rheumatoid arthritis (RA) is a chronic, autoimmune disease which may result in a higher risk of cardiovascular (CV) events and stroke. Tissue characterization and risk stratification of patients with rheumatoid arthritis are a challenging problem. Risk stratification of RA patients using tradition...

journal_title：Current atherosclerosis reports

authors： Khanna NN,Jamthikar AD,Gupta D,Piga M,Saba L,Carcassi C,Giannopoulos AA,Nicolaides A,Laird JR,Suri HS,Mavrogeni S,Protogerou AD,Sfikakis P,Kitas GD,Suri JS

更新日期：2019-01-25 00:00:00

abstract：:In the USA, 69 % of adults are either overweight or obese and 35 % are obese. Obesity is associated with an increased incidence of various cardiovascular disorders. Obesity is a risk marker for cardiovascular disease, in that it is associated with a much higher prevalence of comorbidities such as diabetes, hypertensio...

journal_title：Current atherosclerosis reports

authors： Mandviwala T,Khalid U,Deswal A

更新日期：2016-05-01 00:00:00

abstract：:Aggressive lipid lowering was initially controversial due to evidence from epidemiologic studies that implied an increase in total mortality with low cholesterol levels combined with equivocal results from early trials utilizing bile acid resins or fibric acid derivatives. The advent of statin therapy allowed signific...

journal_title：Current atherosclerosis reports

authors： Todd J,Farmer JA

更新日期：2006-03-01 00:00:00

abstract：:Patients with ischemic stroke of unclear etiology are often screened for hypercoagulable syndromes or thrombophilias. These have been recognized to cause venous thrombosis, and include hereditary deficiencies of coagulation factors, genetic mutations, or acquired disorders. However, the majority of coagulation disorde...

journal_title：Current atherosclerosis reports

authors： Bushnell C,Goldstein LB

更新日期：2003-07-01 00:00:00

abstract：:Functional foods are foods that, by virtue of physiologically active food components, provide health benefits beyond basic nutrition. Many functional foods have been found to be potentially beneficial in the prevention and treatment of cardiovascular disease, the leading cause of mortality in the United States. These ...

journal_title：Current atherosclerosis reports

authors： Hasler CM,Kundrat S,Wool D

更新日期：2000-11-01 00:00:00

abstract：:Inflammation lies at the base of endothelial dysfunction, eventually leading to plaque formation. The degree of inflammation defines the "vulnerability" of plaque to rupture. Numerous strategies have been adopted to identify and eventually treat high-risk vulnerable plaque. Lipoprotein-associated phospholipase A(2) (L...

journal_title：Current atherosclerosis reports

authors： Bhatti S,Hakeem A,Cilingiroglu M

更新日期：2010-03-01 00:00:00

abstract：:Lipoprotein apheresis is an extracorporeal therapy whereby apo B-containing lipoproteins (LDL, vLDL, and Lp(a)) are selectively removed from the plasma of a patient. It is a variation of plasma exchange, which non-selectively removes all plasma proteins. Lipoprotein apheresis is most commonly used to treat patients wi...

journal_title：Current atherosclerosis reports

authors： Bhoj VG,Sachais BS

更新日期：2015-07-01 00:00:00

abstract：:Abdominal aortic aneurysms (AAAs) are a common but asymptomatic disease that has high susceptibility to rupture. Current therapeutic options are limited to surgical procedures because no pharmacological approaches have been proven to decrease either expansion or rupture of human AAAs. The current dearth of effective m...

journal_title：Current atherosclerosis reports

authors： Lu H,Rateri DL,Bruemmer D,Cassis LA,Daugherty A

更新日期：2012-10-01 00:00:00

abstract：:While the discovery of microRNAs has exponentially expanded our understanding of the regulatory mechanisms governing gene networks in many biological processes, the study of these tiny RNA powerhouses in cardiovascular disease is in its infancy. To date, there have been over 1200 human microRNAs identified, and they a...

journal_title：Current atherosclerosis reports

authors： Rayner KJ,Moore KJ

更新日期：2012-10-01 00:00:00

abstract：:Atherosclerotic cardiovascular diseases are the most common causes of death in the United States. Fibrous plaques develop in 77% to 78% of men before age 30. The mean low-density lipoprotein-cholesterol (LDL-C) level in men aged 25 to 30 years is 117 mg/dL. In the Air Force/Texas Coronary Atherosclerosis Prevention St...

journal_title：Current atherosclerosis reports

authors： Whitney E

更新日期：1999-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This review addresses normal and pathologic functions of serum amyloid A (SAA), an enigmatic biomarker of inflammation and protein precursor of AA amyloidosis, a life-threatening complication of chronic inflammation. SAA is a small, highly evolutionarily conserved acute-phase protein whose plasma leve...

journal_title：Current atherosclerosis reports

authors： Gursky O

更新日期：2020-09-24 00:00:00