Abstract：
:Abdominal aortic aneurysms (AAAs) are a common but asymptomatic disease that has high susceptibility to rupture. Current therapeutic options are limited to surgical procedures because no pharmacological approaches have been proven to decrease either expansion or rupture of human AAAs. The current dearth of effective medical treatment is attributed to insufficient understanding of the mechanisms underlying the initiation, propagation and rupture of AAAs. This review will emphasize recent advances in mechanistic studies that may provide insights into potential pharmacological treatments for this disease. While we primarily focus on recent salient findings, we also discuss mechanisms that continue to be controversial depending on models under study. Despite the progress on exploring mechanisms of experimental AAAs, ultimate validation of mechanisms will require completion of prospective double-blinded clinical trials. In addition, we advocate increased emphasis of collaborative studies using animal models and human tissues for determination of mechanisms that explore expansion and rupture of existing AAAs.
journal_name
Curr Atheroscler Repjournal_title
Current atherosclerosis reportsauthors
Lu H,Rateri DL,Bruemmer D,Cassis LA,Daugherty Adoi
10.1007/s11883-012-0271-ysubject
Has Abstractpub_date
2012-10-01 00:00:00pages
402-12issue
5eissn
1523-3804issn
1534-6242journal_volume
14pub_type
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pub_type： 杂志文章,评审
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更新日期：2012-06-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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pub_type： 杂志文章,评审
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更新日期：2020-01-07 00:00:00
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journal_title：Current atherosclerosis reports
pub_type： 杂志文章,已发布勘误
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更新日期：2018-06-19 00:00:00
