Omega-3 fatty acids: a growing ocean of choices.

Abstract:

:There has been increasing interest in the health benefits of supplemental and/or dietary omega-3 polyunsaturated fatty acids (PUFAs), particularly in their role in disease prevention. This interest escalated once their effects on cardiovascular health were observed from numerous observational studies in populations whose diet consisted mainly of fish. Research has since been undertaken on omega-3 PUFAs to investigate their health benefits in a vast array of medical conditions, including primary and secondary prevention. This article discusses the evidence and controversies concerning omega-3 PUFAs in various health conditions. In addition to the effects on cardiovascular health, omega-3 PUFAs have been shown to prevent the development of dementia, reduce systemic inflammatory diseases, prevent prostate cancer, and possibly have a role in the treatment of depression and bipolar disorder.

journal_name

Curr Atheroscler Rep

authors

Fares H,Lavie CJ,DiNicolantonio JJ,O'Keefe JH,Milani RV

doi

10.1007/s11883-013-0389-6

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

389

issue

2

eissn

1523-3804

issn

1534-6242

journal_volume

16

pub_type

杂志文章,评审
  • Does differing metabolism by cytochrome p450 have clinical importance?

    abstract::The cytochrome P450 (CYP) is a group of enzymes that oxidatively modify drugs to a more water-soluble form for renal excretion. Nearly 50% of all clinically used medications and endogenous steroids are metabolized by the CYP enzyme 3A4, which explains why many of the important potential drug interactions involved this...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-000-0090-4

    authors: Davidson MH

    更新日期:2000-01-01 00:00:00

  • Radiation-Induced Cardiovascular Disease.

    abstract:PURPOSE OF REVIEW:Thoracic radiation therapy is an effective treatment for several malignancies, such as Hodgkin's lymphoma and breast cancer. Over the years, however, the incidence of cardiovascular events has increased in these patients, notably in younger survivors who do not have traditional risk factors. This revi...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-017-0658-x

    authors: Raghunathan D,Khilji MI,Hassan SA,Yusuf SW

    更新日期:2017-05-01 00:00:00

  • Applied gene therapy in preclinical models of vascular injury.

    abstract::Atherosclerosis remains the major cause of morbidity and mortality in Western countries. Atherothrombotic complications, including vascular occlusions and severe narrowing of nutrient blood vessels in the cerebral, coronary, or peripheral circulation, usually require invasive revascularization strategies. As molecular...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-003-0022-1

    authors: Janssens SP

    更新日期:2003-05-01 00:00:00

  • Stenting in Intracranial Stenosis: Current Controversies and Future Directions.

    abstract::Angioplasty and stenting for intracranial atherosclerotic stenosis (ICAS) are a last resort for patients with high-grade intracranial stenosis with multiple ischemic events unresponsive to medical therapy. Medical management, consisting of aggressive risk factor control and dual antiplatelet therapy, is superior to an...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-015-0527-4

    authors: Chatterjee AR,Derdeyn CP

    更新日期:2015-08-01 00:00:00

  • Paroxysmal Atrial Fibrillation in Cryptogenic Stroke: an Overlooked Explanation?

    abstract::Approximately one third of ischemic strokes are labeled cryptogenic because the etiology is unknown despite a thorough evaluation. Paroxysmal atrial fibrillation carries the same risk of ischemic stroke as persistent atrial fibrillation and has increasingly gained attention as a potential source of cryptogenic stroke....

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-015-0547-0

    authors: Zhang C,Kasner SE

    更新日期:2015-12-01 00:00:00

  • Impact of thiazolidinedione therapy on atherogenesis.

    abstract::Thiazolidinediones (TZDs), which are synthetic ligands for peroxisome proliferator activated receptor g (PPARg) activation, have been introduced in clinical medicine to improve insulin resistance and glycemic control in patients with type 2 diabetes. The metabolic effects of TZDs are mediated by receptor-dependent act...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-005-0049-6

    authors: van Wijk JP,Rabelink TJ

    更新日期:2005-09-01 00:00:00

  • Lipoprotein apheresis.

    abstract::Lipoprotein apheresis is an extracorporeal therapy whereby apo B-containing lipoproteins (LDL, vLDL, and Lp(a)) are selectively removed from the plasma of a patient. It is a variation of plasma exchange, which non-selectively removes all plasma proteins. Lipoprotein apheresis is most commonly used to treat patients wi...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-015-0516-7

    authors: Bhoj VG,Sachais BS

    更新日期:2015-07-01 00:00:00

  • High-Intensity Interval Training in Patients with Type 2 Diabetes Mellitus: a Systematic Review.

    abstract:PURPOSE OF REVIEW:High-intensity exercise may beneficially impact on insulin sensitivity. However, there is still uncertainty on the actual impact of high-intensity interval training (HIIT) on chronic physiologic adaptations among patients with type 2 diabetes mellitus (T2DM). We aimed to systematically search and appr...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章

    doi:10.1007/s11883-019-0767-9

    authors: da Silva DE,Grande AJ,Roever L,Tse G,Liu T,Biondi-Zoccai G,de Farias JM

    更新日期:2019-02-02 00:00:00

  • Pleiotropic effects of statins: moving beyond cholesterol control.

    abstract::3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors or "statin" medications are the most commonly prescribed therapy for lowering cholesterol. In use for over a decade, they have demonstrated both safety and tolerability across a broad range of patients. The ability to inhibit the biosynthesis of cholesterol an...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-005-0073-6

    authors: Garcia PJ

    更新日期:2005-02-01 00:00:00

  • Alcohol and atherosclerosis: recent insights.

    abstract::Light to moderate alcohol intake is known to have cardioprotective properties; however, the magnitude of protection depends on other factors and may be confined to some subsets of the population. This review focuses on factors that modify the relationship between alcohol and coronary heart disease (CHD). The cardiopro...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-007-0007-6

    authors: Tolstrup J,Grønbaek M

    更新日期:2007-08-01 00:00:00

  • AIBP, Angiogenesis, Hematopoiesis, and Atherogenesis.

    abstract:PURPOSE OF REVIEW:The goal of this manuscript is to summarize the current understanding of the secreted APOA1 binding protein (AIBP), encoded by NAXE, in angiogenesis, hematopoiesis, and inflammation. The studies on AIBP illustrate a critical connection between lipid metabolism and the aforementioned endothelial and im...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-020-00899-9

    authors: Qiu X,Luo J,Fang L

    更新日期:2020-11-24 00:00:00

  • Advances in the Detection and Monitoring of Atrial Fibrillation for Patients with Cryptogenic Ischemic Stroke.

    abstract::Atrial fibrillation (AF) is a significant etiologic cause of acute ischemic stroke (AIS) that leads to disabling deficits as well as significant morbidity and mortality in this population. Approximately 25 % of AIS is considered to be cryptogenic with no etiology ascertained at the time of the index event. Recent adva...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-015-0544-3

    authors: Sangha RS,Bernstein R

    更新日期:2015-12-01 00:00:00

  • Imaging Atherosclerotic Plaque Calcification: Translating Biology.

    abstract::Calcification of atherosclerotic lesions was long thought to be an age - related, passive process, but increasingly data has revealed that atherosclerotic calcification is a more active process, involving complex signaling pathways and bone-like genetic programs. Initially, imaging of atherosclerotic calcification was...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-016-0601-6

    authors: Bailey G,Meadows J,Morrison AR

    更新日期:2016-08-01 00:00:00

  • Computerized approaches to communication retraining after stroke.

    abstract::Augmentative and alternative communication (AAC) strategies traditionally have been designed for individuals for whom oral speech is not a viable option. Common clinical practice has expanded AAC use to a tool for cognitive retraining or remediation. Although technologic developments offer the potential for vastly imp...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-002-0008-4

    authors: Ansel BM,Weinrich M

    更新日期:2002-07-01 00:00:00

  • Proteomic and metabolomic profiles in atherothrombotic vascular disease.

    abstract::Atherothrombosis remains a major cause of morbidity and mortality in the western world. The underlying processes associated with clinical expression of atherothrombosis include oxidative stress and proteolysis in relation to neovascularisation and intraplaque hemorrhages, leading to immuno-inflammatory response, cell ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-010-0102-y

    authors: Martinez-Pinna R,Barbas C,Blanco-Colio LM,Tunon J,Ramos-Mozo P,Lopez JA,Meilhac O,Michel JB,Egido J,Martin-Ventura JL

    更新日期:2010-05-01 00:00:00

  • Statins and diabetes: the good, the bad, and the unknown.

    abstract::The ability for statins to reduce major cardiovascular events and mortality has lead to this drug class being the most commonly prescribed in the world. In particular, the benefit of these drugs in type 2 diabetes (T2D) is well established. In February 2012, the Food and Drug Administration released changes to statin ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-012-0299-z

    authors: Axsom K,Berger JS,Schwartzbard AZ

    更新日期:2013-02-01 00:00:00

  • Impact of circulating esterified eicosanoids and other oxylipins on endothelial function.

    abstract::Eicosanoids, including epoxyeicosatrienoic acids, hydroxyeicosatetraenoic acids, and other oxylipins derived from polyunsaturated fatty acids, have emerging roles in endothelial inflammation and subsequent atherosclerosis. Unlike eicosanoids in the prostanoid series, they are known to be esterified in cell lipids such...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-009-0061-3

    authors: Shearer GC,Newman JW

    更新日期:2009-11-01 00:00:00

  • Emerging Evidence that ApoC-III Inhibitors Provide Novel Options to Reduce the Residual CVD.

    abstract:PURPOSE OF REVIEW:Apolipoprotein C-III (apoC-III) is known to inhibit lipoprotein lipase (LPL) and function as an important regulator of triglyceride metabolism. In addition, apoC-III has also more recently been identified as an important risk factor for cardiovascular disease. This review summarizes the mechanisms by ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-019-0791-9

    authors: Taskinen MR,Packard CJ,Borén J

    更新日期:2019-05-20 00:00:00

  • An Update on Gender Disparities in Coronary Heart Disease Care.

    abstract::Coronary heart disease (CHD), traditionally considered a male disease, causes far more deaths in women than cancer. The prevalence of CHD is lower in women at any age, but with advancing age, this differential decreases. The clinical outcomes including myocardial infarction mortality, all-cause mortality, and reinfarc...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-016-0574-5

    authors: Shah T,Palaskas N,Ahmed A

    更新日期:2016-05-01 00:00:00

  • Carotid Atherosclerosis in Patients with Atrial Fibrillation.

    abstract:PURPOSE OF REVIEW:This review aims to explore the relationship between AF and carotid atherosclerosis, and the impact on the outcomes of cardiovascular and cerebrovascular events. Also, our aim is to critically review current knowledge and delineate future directions for effective treatment or prevention as well as str...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-019-0808-4

    authors: Wang Z,Korantzopoulos P,Liu T

    更新日期:2019-11-29 00:00:00

  • The complex genetic basis of plasma triglycerides.

    abstract::Demonstration of a direct relationship between plasma triglyceride (TG) concentration and atherosclerosis has proven difficult due to confounding variables that accompany elevated plasma TG, such as other dyslipidemias, obesity, and type 2 diabetes. However, human genetic studies have provided evidence suggesting a ca...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-012-0243-2

    authors: Johansen CT,Hegele RA

    更新日期:2012-06-01 00:00:00

  • The role of omega-3 fatty acids in cardiovascular disease.

    abstract::Plant-derived alpha-linolenic acid has been studied in a limited number of investigations. So far, some epidemiologic and a few mechanistic studies suggest a potential of protection from cardiovascular disease, but this potential remains to be proven in intervention studies. In contrast, eicosapentaenoic acid (EPA) an...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-003-0086-y

    authors: von Schacky C

    更新日期:2003-03-01 00:00:00

  • Dietary monounsaturated fatty acids appear not to provide cardioprotection.

    abstract::Dietary interventions have been consistently proposed as a part of a comprehensive strategy to lower the incidence and severity of coronary heart disease (CHD), in the process providing long-term cardioprotection. Replacement of dietary saturated fatty acids (SFA) with higher intakes of monounsaturated fatty acids (MU...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-010-0133-4

    authors: Degirolamo C,Rudel LL

    更新日期:2010-11-01 00:00:00

  • Birth Weight and Risk of Cardiovascular Disease Incidence in Adulthood: a Dose-Response Meta-analysis.

    abstract:PURPOSE OF REVIEW:Studies have revealed a relation between birth weight (BW) and later risk of cardiovascular diseases (CVDs). This meta-analysis aimed to report the dose-response relationship between BW and risk of CVDs. RECENT FINDINGS:The relation of BW to CVD subtypes was found to be U-shaped as BW below ~ 2500 g ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s11883-020-0829-z

    authors: Mohseni R,Mohammed SH,Safabakhsh M,Mohseni F,Monfared ZS,Seyyedi J,Mejareh ZN,Alizadeh S

    更新日期:2020-04-23 00:00:00

  • Antisense Oligonucleotides Targeting Lipoprotein(a).

    abstract:PURPOSE OF REVIEW:High lipoprotein(a) levels are observationally and causally, from human genetics, associated with increased risk of cardiovascular disease including myocardial infarction and aortic valve stenosis. The European Atherosclerosis Society recommends screening for elevated lipoprotein(a) levels in high-ris...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-019-0792-8

    authors: Langsted A,Nordestgaard BG

    更新日期:2019-05-20 00:00:00

  • A Clinical Guide to Combination Lipid-Lowering Therapy.

    abstract:PURPOSE OF REVIEW:We provide an overview of our current understanding of combination lipid-lowering therapies intended for dyslipidemia treatment and cardiovascular disease prevention. First, we analyze recent statin and non-statin combination therapy guidelines and clinical studies since the publication of 2013 Americ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-018-0721-2

    authors: Russell C,Sheth S,Jacoby D

    更新日期:2018-03-07 00:00:00

  • Postprandial hypertriglyceridemia and cardiovascular disease: current and future therapies.

    abstract::Exaggerated postprandial hypertriglyceridemia is a risk factor for cardiovascular disease. This metabolic abnormality is principally due to overproduction and/or decreased catabolism of triglyceride-rich lipoproteins (TRLs) and is a consequence of pathogenic genetic variations and other coexistent medical conditions, ...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-013-0309-9

    authors: Chan DC,Pang J,Romic G,Watts GF

    更新日期:2013-03-01 00:00:00

  • Optimal low-density lipoprotein levels: evidence from epidemiology and clinical trials.

    abstract::Aggressive lipid lowering was initially controversial due to evidence from epidemiologic studies that implied an increase in total mortality with low cholesterol levels combined with equivocal results from early trials utilizing bile acid resins or fibric acid derivatives. The advent of statin therapy allowed signific...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-006-0053-5

    authors: Todd J,Farmer JA

    更新日期:2006-03-01 00:00:00

  • The Air Force/Texas Coronary Atherosclerosis Prevention Study: implications for preventive cardiology in the general adult US population.

    abstract::Atherosclerotic cardiovascular diseases are the most common causes of death in the United States. Fibrous plaques develop in 77% to 78% of men before age 30. The mean low-density lipoprotein-cholesterol (LDL-C) level in men aged 25 to 30 years is 117 mg/dL. In the Air Force/Texas Coronary Atherosclerosis Prevention St...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章

    doi:10.1007/s11883-999-0048-0

    authors: Whitney E

    更新日期:1999-07-01 00:00:00

  • Mechanisms of abdominal aortic aneurysm formation.

    abstract::Abdominal aortic aneurysms (AAA) are permanent dilations in the infra-renal area in which the arterial tissue is characterized by inflammation and medial degeneration. AAAs are a common vascular disorder and cause significant mortality in the aged population. Despite the high prevalence of this disease, there is limit...

    journal_title:Current atherosclerosis reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11883-002-0023-5

    authors: Daugherty A,Cassis LA

    更新日期:2002-05-01 00:00:00