Abstract:
PURPOSE OF REVIEW:To summarize epidemiology, pathophysiology, prognostic relevance, and treatment options of coronary artery disease (CAD) when coupled with severe aortic stenosis (SAS). In regard to treatment options, we focused on the most recently adopted therapeutic approaches and on the future perspectives in light of the latest percutaneous and surgical technical improvements in the field of both CAD and SAS management. RECENT FINDINGS:Nowadays, SAS is the most common valve disease requiring intervention, either surgical or percutaneous. On the other side, CAD is one of the leading causes of death in the developed countries. CAD and degenerative SAS share several predisposing factors and are often concurrently found in clinical practice. Despite in the last years the transcatheter aortic valve replacement (TAVR) has been deeply changing the therapeutic approach to SAS, the correct management of patients with concomitant CAD remains controversial due to limited and heterogeneous data in the literature. Coronary revascularization is often performed in patients with concomitant CAD and SAS. Complete surgical approach is still the standard of care according to international guidelines. However, in light of the recent results of TAVR trials, the therapeutic approach is expected to change. To date, percutaneous coronary intervention performed before TAVR is safe and feasible even if the optimal timing for revascularization remains debated. Due to the great complexity of the patients affected by SAS and CAD and until unquestionable truths will come from large randomized trials, the role of the Heart Team in the decision-making process is of primary importance to guarantee the best tailored therapeutic strategy for the single patient.
journal_name
Curr Atheroscler Repjournal_title
Current atherosclerosis reportsauthors
Pepe M,Larosa C,Rosa I,Biondi-Zoccai G,Nestola PL,Di Cillo O,Bortone AS,Giordano A,Favale Sdoi
10.1007/s11883-020-0835-1subject
Has Abstractpub_date
2020-05-26 00:00:00pages
17issue
5eissn
1523-3804issn
1534-6242pii
10.1007/s11883-020-0835-1journal_volume
22pub_type
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journal_title:Current atherosclerosis reports
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journal_title:Current atherosclerosis reports
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journal_title:Current atherosclerosis reports
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pub_type: 杂志文章,评审
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更新日期:2000-03-01 00:00:00
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journal_title:Current atherosclerosis reports
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journal_title:Current atherosclerosis reports
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更新日期:2007-01-01 00:00:00
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-018-0721-2
更新日期:2018-03-07 00:00:00
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
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更新日期:2003-03-01 00:00:00
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
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更新日期:2000-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2002-03-01 00:00:00
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
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更新日期:2020-09-03 00:00:00
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-012-0272-x
更新日期:2012-10-01 00:00:00
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-013-0371-3
更新日期:2013-12-01 00:00:00
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
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更新日期:2009-03-01 00:00:00
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章
doi:10.1007/s11883-999-0048-0
更新日期:1999-07-01 00:00:00
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-007-0039-y
更新日期:2007-10-01 00:00:00
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-018-0751-9
更新日期:2018-08-29 00:00:00
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
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更新日期:2016-05-01 00:00:00
abstract:PURPOSE OF REVIEW:High lipoprotein(a) levels are observationally and causally, from human genetics, associated with increased risk of cardiovascular disease including myocardial infarction and aortic valve stenosis. The European Atherosclerosis Society recommends screening for elevated lipoprotein(a) levels in high-ris...
journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
doi:10.1007/s11883-019-0792-8
更新日期:2019-05-20 00:00:00
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章,已发布勘误
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更新日期:2018-06-19 00:00:00
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
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更新日期:2015-06-01 00:00:00
abstract::Although the role of implantable cardioverter defibrillator (ICD) and cardiac resynchronization therapy (CRT) in improving outcomes in ischemic cardiomyopathy (ICM) has been described, the data regarding gender-based survival outcomes are limited. There is a higher preponderance of non-ischemic cardiomyopathy (NICM) i...
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2003-05-01 00:00:00
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
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更新日期:2012-10-01 00:00:00
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
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更新日期:2013-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2017-10-23 00:00:00
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
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更新日期:2020-11-24 00:00:00
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
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更新日期:2002-05-01 00:00:00
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journal_title:Current atherosclerosis reports
pub_type: 杂志文章,评审
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更新日期:2001-07-01 00:00:00