当前位置： SCI文献检索 > JOURNAL OF BIOMECHANICS期刊下所有文献 > Spatial distribution and remodeling of elastic modulus of bone in micro-regime as prediction of early stage osteoporosis.

Spatial distribution and remodeling of elastic modulus of bone in micro-regime as prediction of early stage osteoporosis.

Abstract：

:We assessed the local distribution of bone mechanical properties on a micro-nano-scale and its correlation to strain distribution. Left tibia samples were obtained from 5-month old female Sprague Dawley rats, including baseline control (n=9) and hindlimb suspended (n=9) groups. Elastic modulus was measured by nanoindentation at the dedicated locations. Three additional tibias from control rats were loaded axially to measure bone strain, with 6-10N at 1Hz on a Bose machine for strain measurements. In the control group, the difference of the elastic modulus between periosteum and endosteum was much higher at the anterior and posterior regions (2.6GPa), where higher strain differences were observed (45μɛ). Minimal elastic modulus difference between periosteum and endosteum was observed at the medial region (0.2GPa), where neutral axis of the strain distribution was oriented with lower strain difference (5μɛ). In the disuse group, however, the elastic modulus differences in the anterior posterior regions reduced to 1.2GPa from 2.6GPa in the control group, and increased in the medial region to 2.7GPa from 0.2GPa. It is suggested that the remodeling rate in a region of bone is possibly influenced by the strain gradient from periosteum to endosteum. Such pattern of moduli gradients was compromised in disuse osteopenia, suggesting that the remodeling in distribution of micro-nano-elastic moduli among different regions may serve as a predictor for early stage of osteoporosis.

journal_name

J Biomech

journal_title

Journal of biomechanics

authors

Grover K,Lin L,Hu M,Muir J,Qin YX

doi

10.1016/j.jbiomech.2015.11.052

subject

Has Abstract

pub_date

2016-01-25 00:00:00

pages

161-6

issue

2

eissn

0021-9290

issn

1873-2380

pii

S0021-9290(15)00694-6

journal_volume

49

pub_type

杂志文章

相关文献

JOURNAL OF BIOMECHANICS文献大全
  • Combined effects of microtopography and cyclic strain on vascular smooth muscle cell orientation.

    abstract：:Cellular alignment studies have shown that cell orientation has a large effect on the expression and behavior of cells. Cyclic strain and substrate microtopography have each been shown to regulate cellular alignment. This study examined the combined effects of these two stimuli on the alignment of bovine vascular smoo...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2007.11.027

    authors： Houtchens GR,Foster MD,Desai TA,Morgan EF,Wong JY

    更新日期：2008-01-01 00:00:00

  • A computer-controlled mechanical culture system for biological testing of articular cartilage explants.

    abstract：:A computer-controlled mechanical culture system was designed to investigate the interaction between mechanical stimuli and the metabolism of articular cartilage. The main features of this system include the following capabilities: (1) Accurately controlled static, permanent cyclic or intermittent cyclic mechanical loa...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/s0021-9290(97)00040-7

    authors： Steinmeyer J

    更新日期：1997-08-01 00:00:00

  • A force plate study of avian gait.

    abstract：OBJECTIVE:To test the force plate as a gait analysis system for broilers and to determine how the ground reaction force (GRF) patterns change in these birds with growth and administration of analgesia. MATERIALS AND METHODS:Thirty-three male Ross 308 chicks were raised on either an ad libitum or restricted-feeding reg...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2006.09.014

    authors： Corr SA,McCorquodale C,McDonald J,Gentle M,McGovern R

    更新日期：2007-01-01 00:00:00

  • Crack growth resistance in cortical bone: concept of microcrack toughening.

    abstract：:The role of microcracking in cortical bone as a toughening mechanism has been investigated in conjunction with the variation in fracture toughness with crack length. Fracture toughness tests were conducted on miniaturised compact tension specimens made from human and bovine cortical bone and the resultant microstructu...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/s0021-9290(97)00029-8

    authors： Vashishth D,Behiri JC,Bonfield W

    更新日期：1997-08-01 00:00:00

  • Differences in 3D vs. 2D analysis in lumbar spinal fusion simulations.

    abstract：:Lumbar interbody fusion is currently the gold standard in treating patients with disc degeneration or segmental instability. Despite it having been used for several decades, the non-union rate remains high. A failed fusion is frequently attributed to an inadequate mechanical environment after instrumentation. Finite e...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2018.03.009

    authors： Hsu HW,Bashkuev M,Pumberger M,Schmidt H

    更新日期：2018-04-27 00:00:00

  • In vivo implant forces acting on a vertebral body replacement during upper body flexion.

    abstract：:Knowledge about in vivo spinal loads is required for the identification of risk factors for low back pain and for realistic preclinical testing of spinal implants. Therefore, the aim of the present study was to measure the in vivo forces on a vertebral body replacement (VBR) during trunk flexion and to analyze in deta...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2015.01.007

    authors： Dreischarf M,Albiol L,Zander T,Arshad R,Graichen F,Bergmann G,Schmidt H,Rohlmann A

    更新日期：2015-02-26 00:00:00

  • Simulation of mechanical behavior of temperature-responsive braided stents made of shape memory polyurethanes.

    abstract：:Polymeric stents can be considered as an alternative to metallic stents thanks to their lessened incidence of restenosis and controlled deployment. The purpose of this study was to investigate the feasibility of developing a temperature-responsive braided stent using shape memory polyurethane (SMPU) through finite ele...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2009.10.032

    authors： Kim JH,Kang TJ,Yu WR

    更新日期：2010-03-03 00:00:00

  • How muscle architecture and moment arms affect wrist flexion-extension moments.

    abstract：:The purpose of this investigation was to determine how the moment arms and architecture of the wrist muscles influence their isometric moment-generating characteristics. A three-dimensional computer graphic model was developed that estimates the moment arms, maximum isometric forces, and maximum isometric flexion-exte...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/s0021-9290(97)00015-8

    authors： Gonzalez RV,Buchanan TS,Delp SL

    更新日期：1997-07-01 00:00:00

  • Estimation of the Young's modulus of articular cartilage using an arthroscopic indentation instrument and ultrasonic measurement of tissue thickness.

    abstract：:We evaluated whether the use of cartilage thickness measurement would improve the ability of the arthroscopic indentation technique to estimate the intrinsic stiffness of articular cartilage. First, cartilage thickness and ultrasound reflection from the surface of bovine humeral head were registered in situ using a hi...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/s0021-9290(00)00189-5

    authors： Töyräs J,Lyyra-Laitinen T,Niinimäki M,Lindgren R,Nieminen MT,Kiviranta I,Jurvelin JS

    更新日期：2001-02-01 00:00:00

  • Anatomic variation in the elastic inhomogeneity and anisotropy of human femoral cortical bone tissue is consistent across multiple donors.

    abstract：:Numerical models commonly account for elastic inhomogeneity in cortical bone using power-law scaling relationships with various measures of tissue density, but limited experimental data exists for anatomic variation in elastic anisotropy. A recent study revealed anatomic variation in the magnitude and anisotropy of el...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2011.04.009

    authors： Rudy DJ,Deuerling JM,Espinoza Orías AA,Roeder RK

    更新日期：2011-06-03 00:00:00

  • Combining muscle synergies and biomechanical analysis to assess gait in stroke patients.

    abstract：:The understanding of biomechanical deficits and impaired neural control of gait after stroke is crucial to prescribe effective customized treatments aimed at improving walking function. Instrumented gait analysis has been increasingly integrated into the clinical practice to enhance precision and inter-rater reliabili...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2017.08.006

    authors： Barroso FO,Torricelli D,Molina-Rueda F,Alguacil-Diego IM,Cano-de-la-Cuerda R,Santos C,Moreno JC,Miangolarra-Page JC,Pons JL

    更新日期：2017-10-03 00:00:00

  • Measurement of body segment parameters using dual energy X-ray absorptiometry and three-dimensional geometry: an application in gait analysis.

    abstract：:Body segment parameters (BSP) are essential input for the computations in kinetics of motion applied in the field of biomechanics. These data are usually obtained from population-specific predictive equations which present limitations in being representative of the population under study. More recently, medical imagin...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2008.10.036

    authors： Lee MK,Le NS,Fang AC,Koh MT

    更新日期：2009-02-09 00:00:00

  • Compressive creep behavior of bovine trabecular bone.

    abstract：:There are almost no published data that describe the creep behavior of trabecular bone (at the specimen level), even though the creep behavior of cortical bone has been well documented. In an effort to characterize the creep behavior of trabecular bone and to compare it with that of cortical bone, we performed uniaxia...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章,评审

    doi：10.1016/0021-9290(94)90006-x

    authors： Bowman SM,Keaveny TM,Gibson LJ,Hayes WC,McMahon TA

    更新日期：1994-03-01 00:00:00

  • Effect of variable periodontal ligament thickness and its non-linear material properties on the location of a tooth's centre of resistance.

    abstract：:In orthodontics, the 3D translational and rotational movement of a tooth is determined by the force-moment system applied and the location of the tooth's centre of resistance (CR). Because of the practical constraints of in-vivo experiments, the finite element (FE) method is commonly used to determine the CR. The obje...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2019.07.043

    authors： Schmidt F,Lapatki BG

    更新日期：2019-09-20 00:00:00

  • Validation of the greater trochanter method with radiographic measurements of frontal plane hip joint centers and knee mechanical axis angles and two other hip joint center methods.

    abstract：:Several motion capture methods exist for predicting hip joint centers (HJC). These methods include regression models, functional joints, and projections from greater trochanters. While regression and functional methods have been compared to imaging techniques, the TROCH method has not been previously validated. The pu...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2016.06.013

    authors： Bennett HJ,Shen G,Weinhandl JT,Zhang S

    更新日期：2016-09-06 00:00:00

  • Why mechanobiology? A survey article.

    abstract：:The central paradigm of skeletal mechanobiology is that mechanical forces modulate morphological and structural fitness of the skeletal tissues-bone, cartilage, ligament and tendon. Traditionally, skeletal biomechanics has focussed on how these tissues perform the structural and locomotory functions of the vertebrate ...

    journal_title：Journal of biomechanics

    pub_type：

    doi：10.1016/s0021-9290(01)00184-1

    authors： van der Meulen MC,Huiskes R

    更新日期：2002-04-01 00:00:00

  • Temporal changes of mechanical signals and extracellular composition in human intervertebral disc during degenerative progression.

    abstract：:In this study, a three-dimensional finite element model was used to investigate the changes in tissue composition and mechanical signals within human lumbar intervertebral disc during the degenerative progression. This model was developed based on the cell-activity coupled mechano-electrochemical mixture theory. The d...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2014.09.004

    authors： Zhu Q,Gao X,Gu W

    更新日期：2014-11-28 00:00:00

  • Modelling the mechanical effect of muscles with large attachment sites: application to the shoulder mechanism.

    abstract：:A general theory is described for deriving the mechanical effect of muscles with large attachment sites. In a cadaver experiment the complete attachment sites and bundle distribution of 16 muscles of the shoulder mechanism were recorded. These data were used to calculate the mechanical effect, i.e. the resulting force...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/0021-9290(91)90007-a

    authors： Van der Helm FC,Veenbaas R

    更新日期：1991-01-01 00:00:00

  • Shoe midsole hardness, sex and age effects on lower extremity kinematics during running.

    abstract：:Previous studies investigating the effects of shoe midsole hardness on running kinematics have often used male subjects from within a narrow age range. It is unknown whether shoe midsole hardness has the same kinematic effect on male and female runners as well as runners from different age categories. As sex and age h...

    journal_title：Journal of biomechanics

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jbiomech.2012.03.027

    authors： Nigg BM,Baltich J,Maurer C,Federolf P

    更新日期：2012-06-01 00:00:00

  • Measurement of local diffusion and composition in degraded articular cartilage reveals the unique role of surface structure in controlling macromolecular transport.

    abstract：:Developing effective therapeutics for osteoarthritis (OA) necessitates that such molecules can reach and target chondrocytes within articular cartilage. However, predicting how well very large therapeutic molecules diffuse through cartilage is often difficult, and the relationship between local transport mechanics for...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2018.10.019

    authors： DiDomenico CD,Kaghazchi A,Bonassar LJ

    更新日期：2019-01-03 00:00:00

  • Velocities and stress levels of axisymmetric, azimuthal flow within the toroidal rotary seal of the IBM 2997 continuous flow cell separator and the implications.

    abstract：:Continuous flow blood fraction separators are used to facilitate the removal of specific blood components for donation or for certain medical procedures. Problems with one such device, the IBM 2997 Blood Processor, have been noted in a number of independent investigations. A key feature of this particular unit is a ce...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/0021-9290(86)90163-6

    authors： Harvey CB,O'Rear EA

    更新日期：1986-01-01 00:00:00

  • Heterogeneous linear elastic trabecular bone modelling using micro-CT attenuation data and experimentally measured heterogeneous tissue properties.

    abstract：:High-resolution voxel-based finite element software, such as FEEBE developed at the NCBES, is widely used for studying trabecular bone at the micro-scale. A new approach to determine heterogeneous bone tissue material properties for computational models was proposed in this study. The specimen-specific range of tissue...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2008.05.014

    authors： Harrison NM,McDonnell PF,O'Mahoney DC,Kennedy OD,O'Brien FJ,McHugh PE

    更新日期：2008-08-07 00:00:00

  • Simulation of quadrupedal locomotion using a rigid body model.

    abstract：:Locomotion of the horse is simulated using a mathematical model based on rigid body dynamics. A general method to generate the equations of motion for a two-dimensional rigid body model with an arbitrary number of hinge joints is presented and a numerical solution method, restricted to tree-structured models, is descr...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/0021-9290(89)90182-6

    authors： van den Bogert AJ,Schamhardt HC,Crowe A

    更新日期：1989-01-01 00:00:00

  • The effect of shortening history on isometric and dynamic muscle function.

    abstract：:Despite numerous reports on isometric force depression, few reports have quantified force depression during active muscle shortening (dynamic force depression). The purpose of this investigation was to determine the influence of shortening history on isometric force following active shortening, force during isokinetic...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2009.10.041

    authors： McDaniel J,Elmer SJ,Martin JC

    更新日期：2010-03-03 00:00:00

  • Effects of intervertebral disc lesion and multifidus muscle resection on the structure of the lumbar intervertebral discs and paraspinal musculature of the rat.

    abstract：:The aim of this study was to investigate whether elimination of multifidus muscle in rats causes intervertebral disc (IVD) degeneration similar to that found after IVD lesion. Data were obtained from 36 male Wistar rats randomly assigned to one of three groups: (i) IVD lesion, in which the L4/L5 IVD was stabbed; (ii) ...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2018.01.004

    authors： Maas H,Noort W,Hodges PW,van Dieën J

    更新日期：2018-03-21 00:00:00

  • A theoretical study of the influence of bone maturation rate on surface remodeling predictions: idealized models.

    abstract：:The use of a finite element based computational method, RFEM3D, is described for the study of strain-induced bone remodeling. The purpose of the research is to find the potential influence on the predictions of surface bone remodeling when various models for the maturation of newly deposited bone are used. A parameter...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/0021-9290(90)90015-u

    authors： Hart RT

    更新日期：1990-01-01 00:00:00

  • An improved method to assess torsional properties of rodent long bones.

    abstract：:Torsion is an important testing modality commonly used to calculate structural properties of long bones. However, the effects of size and geometry must be excluded from the overall structural response in order to compare material properties of bones of different size, age and species. We have developed a new method to...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2009.04.019

    authors： Nazarian A,Entezari V,Vartanians V,Müller R,Snyder BD

    更新日期：2009-08-07 00:00:00

  • Jet collisions and vortex reversal in the human left ventricle.

    abstract：:Unnatural dynamics of the notorious vortex in the left ventricle is often associated with cardiac disease. Understanding how different cardiac diseases alter the flow physics in the left ventricle may therefore provide a powerful tool for disease detection. In this work, the fluid dynamics in the left ventricle subjec...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2018.07.023

    authors： Di Labbio G,Kadem L

    更新日期：2018-09-10 00:00:00

  • Elbow and wrist joint contact forces during occupational pick and place activities.

    abstract：:A three-dimensional, mathematical model of the elbow and wrist joints, including 15 muscle units, 3 ligaments and 4 joint forces, has been developed. A new strain gauge transducer has been developed to measure functional grip forces. The device measures radial forces divided into six components and forces of up to 250...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/s0021-9290(99)00184-0

    authors： Chadwick EK,Nicol AC

    更新日期：2000-05-01 00:00:00

  • Compact bone: numerical simulation of mechanical characteristics.

    abstract：:One of the main difficulties encountered in the numerical simulation of the anisotropic elastic characteristics of compact bone is to account for the Haversian microstructure when determining the overall macroscopic behavior. Engineering analyses of such problems are usually based on 'homogenized approximations'. Comp...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/0021-9290(93)90031-9

    authors： Crolet JM,Aoubiza B,Meunier A

    更新日期：1993-06-01 00:00:00