Abstract：
:High-resolution voxel-based finite element software, such as FEEBE developed at the NCBES, is widely used for studying trabecular bone at the micro-scale. A new approach to determine heterogeneous bone tissue material properties for computational models was proposed in this study. The specimen-specific range of tissue moduli across strut width was determined from nanoindentation testing. This range was mapped directly using linear interpolation to that specimen's micro-computed tomography (microCT) grey value range as input material properties for finite element analysis. The method was applied to cuboid trabecular bone samples taken from eight, 4-year-old (skeletally mature) ovine L5 vertebrae. Before undergoing experimental uniaxial compression tests, the samples were microCT scanned and 30 microm resolution finite element models were generated. The linear elastic finite element models were compressed to 1% strain. This material property assignment method for computational models accurately reproduced the experimentally determined apparent modulus and concentrations of stress at locations of failure.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Harrison NM,McDonnell PF,O'Mahoney DC,Kennedy OD,O'Brien FJ,McHugh PEdoi
10.1016/j.jbiomech.2008.05.014subject
Has Abstractpub_date
2008-08-07 00:00:00pages
2589-96issue
11eissn
0021-9290issn
1873-2380pii
S0021-9290(08)00248-0journal_volume
41pub_type
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