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Temporal changes of mechanical signals and extracellular composition in human intervertebral disc during degenerative progression.

Abstract：

:In this study, a three-dimensional finite element model was used to investigate the changes in tissue composition and mechanical signals within human lumbar intervertebral disc during the degenerative progression. This model was developed based on the cell-activity coupled mechano-electrochemical mixture theory. The disc degeneration was simulated by lowering nutrition levels at disc boundaries, and the temporal and spatial distributions of the fixed charge density, water content, fluid pressure, Von Mises stress, and disc deformation were analyzed. Results showed that fixed charge density, fluid pressure, and water content decreased significantly in the nucleus pulposus (NP) and the inner to middle annulus fibrosus (AF) regions of the degenerative disc. It was found that, with degenerative progression, the Von Mises stress (relative to that at healthy state) increased within the disc, with a larger increase in the outer AF region. Both the disc volume and height decreased with the degenerative progression. The predicted results of fluid pressure change in the NP were consistent with experimental findings in the literature. The knowledge of the variations of temporal and spatial distributions of composition and mechanical signals within the human IVDs provide a better understanding of the progression of disc degeneration.

journal_name

J Biomech

journal_title

Journal of biomechanics

authors

Zhu Q,Gao X,Gu W

doi

10.1016/j.jbiomech.2014.09.004

subject

Has Abstract

pub_date

2014-11-28 00:00:00

pages

3734-43

issue

15

eissn

0021-9290

issn

1873-2380

pii

S0021-9290(14)00470-9

journal_volume

47

pub_type

杂志文章

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