Abstract:
:Cervical spine finite element models reported in biomechanical literature usually represent a static morphology. Not considering morphology as a model parameter limits the predictive capabilities for applications in personalized medicine, a growing trend in modern clinical practice. The objective of the study was to investigate the influence of variations in spinal morphology on the flexion-extension responses, utilizing mesh-morphing-based parametrization and metamodel-based sensitivity analysis. A C5-C6 segment was used as the baseline model. Variations of intervertebral disc height, facet joint slope, facet joint articular processes height, vertebral body anterior-posterior depth, and segment size were parametrized. In addition, material property variations of ligaments were considered for sensitivity analysis. The influence of these variations on vertebral rotation and forces in the ligaments were analyzed. The disc height, segmental size, and body depth were found to be the most influential (in the cited order) morphology variations; while among the ligament material property variations, capsular ligament and ligamentum flavum influenced vertebral rotation the most. Changes in disc height influenced forces in the posterior ligaments, indicating that changes in the anterior load-bearing column of the spine could have consequences on the posterior column. A method to identify influential morphology variations is presented in this work, which will help automation efforts in modeling to focus on variations that matter. This study underscores the importance of incorporating influential morphology parameters, easily obtained through computed tomography/magnetic resonance images, to better predict subject-specific biomechanical responses for applications in personalized medicine.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
John JD,Saravana Kumar G,Yoganandan Ndoi
10.1016/j.jbiomech.2018.12.044subject
Has Abstractpub_date
2019-03-06 00:00:00pages
18-26eissn
0021-9290issn
1873-2380pii
S0021-9290(19)30007-7journal_volume
85pub_type
杂志文章abstract::In attempts to better understand the etiology of osteoarthritis, a debilitating joint disease that results in the degeneration of articular cartilage (AC) in synovial joints, researchers have focused on joint tribology, the study of joint friction, lubrication, and wear. Several different approaches have been used to ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2009.05.024
更新日期:2009-08-25 00:00:00
abstract::A finite-element micromechanics model for Haversian cortical bone tissue has been developed and studied. The model is an extension of two-dimensional micromechanics techniques for fiber-reinforced composite materials. Haversian systems, or secondary osteons, are considered to be the fiber component, and interstitial l...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/0021-9290(92)90095-i
更新日期:1992-05-01 00:00:00
abstract::The coupling of intravascular and interstitial flow is a distinct feature of tumor microcirculation, due to high vessel permeability, low osmotic pressure gradient and absence of functional lymphatic system inside tumors. We have previously studied the tumor microcirculation by using a 2D coupled model. In this paper,...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2009.01.009
更新日期:2009-04-16 00:00:00
abstract::Wheelchair-dependent subjects often adopt a passive sitting posture and suffer from sitting acquired pressure ulcers (PU) that mainly occur when high buttock pressures sustain for a longer period of time. Body posture directly influences seating load and proper postural change is therefore essential. Many subjects can...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2008.04.012
更新日期:2008-07-19 00:00:00
abstract::Because the hand is a complex poly-articular limb, numerous methods have been proposed to investigate its kinematics therefore complicating the comparison between studies and the methodological choices. With the objective of overcoming such issues, the present study compared the effect of three local frame definitions...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2014.05.025
更新日期:2014-08-22 00:00:00
abstract::Mucosal folding in such biological vessels as esophagus and airway is essential to their physiological functions and can be affected by some diseases, e.g., inflammation, edema, lymphoma, and asthma. A biomechanical model within the framework of finite deformation theory is proposed to address the mucosal folding indu...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2010.09.007
更新日期:2011-01-04 00:00:00
abstract::Minimum foot clearance (MFC) as it relates to trips and falls has been extensively studied across many locomotor tasks, but examination of this body of research yields several studies with conflicting results and a wide range of MFCs within tasks. While there are several factors that may affect the MFC variability acr...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2013.05.002
更新日期:2013-07-26 00:00:00
abstract::Risk for injury during a fall depends on the position and velocity of the body segments at the moment of impact. One technique for reducing impact velocity is to absorb energy in the lower extremity muscles during descent, as occurs during squatting or sitting. However, the protective value of this response may depend...
journal_title:Journal of biomechanics
pub_type: 临床试验,杂志文章
doi:10.1016/j.jbiomech.2003.12.015
更新日期:2004-09-01 00:00:00
abstract::This paper describes the process used to generate lower limb kinematics during single limb stance phase of gait, using musculoskeletal modelling, muscle driven forward simulation and gradient based optimisation techniques (including design of experiment techniques). Initial inputs to the forward simulation process wer...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/s0021-9290(01)00240-8
更新日期:2002-05-01 00:00:00
abstract::In this paper, we apply the micropipette to reduce the surface area of the rabbit aorta, and the relationship between the fractional area change of the aortic surface and the negative pressure in the pipette is studied. The experimental results for seven rabbit thoracic aortas show that the relationship can be express...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/0021-9290(96)00003-6
更新日期:1996-08-01 00:00:00
abstract::One of the main difficulties encountered in the numerical simulation of the anisotropic elastic characteristics of compact bone is to account for the Haversian microstructure when determining the overall macroscopic behavior. Engineering analyses of such problems are usually based on 'homogenized approximations'. Comp...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/0021-9290(93)90031-9
更新日期:1993-06-01 00:00:00
abstract::Falls cause 95% of hip and wrist fractures and 60% of head injuries in older adults. Risk for such injuries depends in part on velocity at contact, and the time available during the fall to generate protective responses. However, we have no information on the impact velocities and durations of falls in older adults. W...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2015.02.025
更新日期:2015-04-13 00:00:00
abstract::Nerve compression due to intervertebral disc (IVD) bulging is a known mechanism for low back pain and typically occurs in the posterior region of the disc. Most in vitro studies are limited in the ability to quantify the magnitude of bulging on the posterior aspect of the disc due to the boney structures that occlude ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2020.109713
更新日期:2020-05-07 00:00:00
abstract::Mechanical environment in callus is determinant for the evolution of bone healing. However, recent mechanobiological computational works have underestimated the effect that growth exerts on the mechanical environment of callus. In the present work, we computationally evaluate the significance of growth-induced stresse...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2011.04.021
更新日期:2011-06-03 00:00:00
abstract::Fatigue or stress fractures are an important clinical problem in humans as well as racehorses. An important question in this context is, when a bone experiences fatigue damage during extreme use, how much is it weakened compared to its original state? Since there are very limited data on this question and stress fract...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/s0021-9290(96)00113-3
更新日期:1997-02-01 00:00:00
abstract::Bone mineral density (BMD) is the principal diagnostic tool used in clinical settings to diagnose and monitor osteoporosis. Experimental studies on ex vivo bone samples from multiple skeletal locations have been used to propose that their breaking stress bears a power-law relationship to volumetric BMD, with a locatio...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2003.12.001
更新日期:2004-08-01 00:00:00
abstract::The physical mechanism that drives blood flow in the valveless tubular embryonic heart is still debatable whether it is peristaltic flow or valveless dynamic suction. Previous studies of valveless pumping were concerned with either the role of the excitation parameters or the mechanisms that generate the unidirectiona...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2015.03.001
更新日期:2015-06-25 00:00:00
abstract::Establishing the appropriate pressure exerted by the shoe upper over the foot surface is fundamental for the design of specific footwear, although measuring the dorsal pressures can also provide important additional information. In previous works, a virtual simulator to perform studies of comfort and functionality in ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2009.06.054
更新日期:2009-09-18 00:00:00
abstract::People with a transtibial amputation have numerous secondary health conditions, including an increased prevalence of low back pain. This increased prevalence may be partially explained by altered low back biomechanics during movement. The purpose of this study was to compare trunk kinematics and L4-L5 lumbar loads in ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2017.12.030
更新日期:2018-03-01 00:00:00
abstract:INTRODUCTION:The postnatal heart grows mostly in response to increased hemodynamic load. However, the specific biomechanical stimuli that stimulate cardiac growth as a reaction to increased hemodynamic load are still poorly understood. It has been shown that isolated neonatal rat cardiac myocytes normalize resting sarc...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2011.11.028
更新日期:2012-03-15 00:00:00
abstract::High-energy synchrotron X-ray scattering (>60 keV) allows noninvasive quantification of internal strains within bone. In this proof-of-principle study, wide angle X-ray scattering maps internal strain vs position in cortical bone (murine tibia, bovine femur) under compression, specifically using the response of the mi...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2010.10.015
更新日期:2011-01-11 00:00:00
abstract::As a hybrid between a hypodermic needle and transdermal patch, we have used microfabrication technology to make arrays of micron-scale needles that transport drugs and other compounds across the skin without causing pain. However, not all microneedle geometries are able to insert into skin at reasonable forces and wit...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2003.12.010
更新日期:2004-08-01 00:00:00
abstract::A non-invasive, in vivo method has been developed to predict the skin flap shrinkage (retraction) following a harvest. It involves the use of a novel custom-designed extensometer to measure the force-displacement behaviour of skin and subsequent data analysis to estimate the shrinkage. In validation experiments perfor...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2008.03.012
更新日期:2008-01-01 00:00:00
abstract::The relation among several parameters of the ramp-and-hold isometric force contraction (peak force and dF/dtmax during the initial phase of force recruitment, and the proportion of hold-phase at target) was quantified for the right and left thumb-index finger pinch, and lower lip midline compression in 40 neurotypical...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2018.02.031
更新日期:2018-04-27 00:00:00
abstract::The clinical relevance of mechanical testing studies of cadaveric human thoracic spines could be enhanced by using follower preload techniques, by including the intact rib cage, and by measuring thoracic intervertebral disc pressures, but studies to date have not incorporated all of these components simultaneously. Th...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2016.02.038
更新日期:2016-05-03 00:00:00
abstract::The tibia from six-week old chickens that develop idiopathic scoliosis were studied with stress relaxation experiments and torsional strength testing. Most parameters observed did not show any significant differences between tibias obtained from chickens with scoliosis and tibias from the control birds; however, the r...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/0021-9290(83)90046-5
更新日期:1983-01-01 00:00:00
abstract::Due to increased atherosclerosis-caused mortality, identification of its genesis and development is of great importance. Although, key factors of the origin of the disease is still unknown, it is widely believed that cholesterol particle penetration and accumulation in arterial wall is mainly responsible for further w...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2017.11.029
更新日期:2018-01-23 00:00:00
abstract::The deformation of red blood cells in microvessels was investigated numerically for various vessel diameters, hematocrits, and shear rates. We simulated blood flow in circular channels with diameters ranging from 9 to 50 μm, hematocrits from 20% to 45%, and shear rates from 20 to 150 s(-1) using a particle-based model...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2012.08.026
更新日期:2012-10-11 00:00:00
abstract::We propose a numerical model of hemodynamics arising from malaria infection. This model is based on a particle method, where all the components of blood are represented by the finite number of particles. A two-dimensional spring network of membrane particles is employed for expressing the deformation of malaria infect...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2010.01.011
更新日期:2010-05-07 00:00:00
abstract::The performance criterion in maximum vertical jumping has typically been assumed to simply raise the center of mass as high as possible. In many sporting activities minimizing movement time during the jump is likely also critical to successful performance. The purpose of this study was to examine maximum height jumps ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2015.04.021
更新日期:2015-08-20 00:00:00