Abstract:
:Bone mineral density (BMD) is the principal diagnostic tool used in clinical settings to diagnose and monitor osteoporosis. Experimental studies on ex vivo bone samples from multiple skeletal locations have been used to propose that their breaking stress bears a power-law relationship to volumetric BMD, with a location-dependent index. We argue that a power-law cannot represent effects of trabecular removal, which is one of the leading causes of reduction in bone strength. A new expression, proposed on the basis of theoretical and numerical analysis of a mathematical model, is tested using previously published data on bone samples from iliac crest and vertebral body. It represents the experimental biomechanical data at least as well as the power-law, and provides means for extrapolating results from small biopsy samples to an entire bone. In addition, changes caused by trabecular thinning and anisotropy can be modeled by the expression.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Rajapakse CS,Thomsen JS,Espinoza Ortiz JS,Wimalawansa SJ,Ebbesen EN,Mosekilde L,Gunaratne GHdoi
10.1016/j.jbiomech.2003.12.001keywords:
subject
Has Abstractpub_date
2004-08-01 00:00:00pages
1241-9issue
8eissn
0021-9290issn
1873-2380pii
S0021929003004494journal_volume
37pub_type
杂志文章abstract::Bone is subjected in vivo to both high amplitude, low frequency strain, incurred by locomotion, and to low amplitude, broad frequency strain. The biological effects of low amplitude, broad frequency strain are poorly understood. To evaluate the effects of low amplitude strains ranging in frequency from 0 to 50 Hz on o...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/s0021-9290(02)00245-2
更新日期:2003-01-01 00:00:00
abstract::Fall risk in elderly people is usually assessed using clinical tests. These tests consist in a subjective evaluation of gait performed by healthcare professionals, most of the time shortly after the first fall occurrence. We propose to complement this one-time, subjective evaluation, by a more quantitative analysis of...
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abstract::Measurement of vertebral rotation from frontal X-ray projections of the pedicles was introduced by Nash and Moe. By the introduction of a vertebral model, their method and different modifications can be described and characterized easily. A geometrical analysis shows, that two parameters are sufficient for this model....
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journal_title:Journal of biomechanics
pub_type: 杂志文章
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abstract::Patient-specific simulations of bone remodelling could enable predicting how bone micro-structural integrity would be affected by bone diseases, drugs or other factors, and, ultimately could help clinicians to improve their prognoses. To simulate load-adaptive remodelling, however, knowledge about the physiological ex...
journal_title:Journal of biomechanics
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abstract::Detecting and assessing an individual's gait can be important for medical diagnostic purposes and for developing and guiding follow-on rehabilitation protocols. Thus, an accurate, objective gait classification system has the potential to facilitate earlier diagnosis and improved clinical decision-making. Systems using...
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abstract::One of the most popular methods to fabricate biomedical microfluidic devices is by using a soft-lithography technique. However, the fabrication of the moulds to produce microfluidic devices, such as SU-8 moulds, usually requires a cleanroom environment that can be quite costly. Therefore, many efforts have been made t...
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journal_title:Journal of biomechanics
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abstract::Engineering of large articular cartilage tissue constructs remains a challenge as tissue growth is limited by nutrient diffusion. Here, a novel strategy is investigated, generating large constructs through the assembly of individually cultured, interlocking, smaller puzzle-shaped subunits. These constructs can be engi...
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