An expression relating breaking stress and density of trabecular bone.

Abstract:

:Bone mineral density (BMD) is the principal diagnostic tool used in clinical settings to diagnose and monitor osteoporosis. Experimental studies on ex vivo bone samples from multiple skeletal locations have been used to propose that their breaking stress bears a power-law relationship to volumetric BMD, with a location-dependent index. We argue that a power-law cannot represent effects of trabecular removal, which is one of the leading causes of reduction in bone strength. A new expression, proposed on the basis of theoretical and numerical analysis of a mathematical model, is tested using previously published data on bone samples from iliac crest and vertebral body. It represents the experimental biomechanical data at least as well as the power-law, and provides means for extrapolating results from small biopsy samples to an entire bone. In addition, changes caused by trabecular thinning and anisotropy can be modeled by the expression.

journal_name

J Biomech

journal_title

Journal of biomechanics

authors

Rajapakse CS,Thomsen JS,Espinoza Ortiz JS,Wimalawansa SJ,Ebbesen EN,Mosekilde L,Gunaratne GH

doi

10.1016/j.jbiomech.2003.12.001

keywords:

subject

Has Abstract

pub_date

2004-08-01 00:00:00

pages

1241-9

issue

8

eissn

0021-9290

issn

1873-2380

pii

S0021929003004494

journal_volume

37

pub_type

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