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A computer-controlled mechanical culture system for biological testing of articular cartilage explants.

Abstract：

:A computer-controlled mechanical culture system was designed to investigate the interaction between mechanical stimuli and the metabolism of articular cartilage. The main features of this system include the following capabilities: (1) Accurately controlled static, permanent cyclic or intermittent cyclic mechanical loads can be applied; (2) a great variety of different functions to load cartilage explants can be chosen; (3) a wide range of selectable forces (1.0-500 N) and frequencies (up to 5.0 Hz) can be used to load explants; (4) cartilage explants can be cultured and loaded within a standard CO2-incubator for extended time periods; (5) similar culture conditions are provided within the loading chambers as in standard tissue culture plates; (6) simultaneously the applied load and the resulting displacement of specimens is measured, and (7) the load chambers are biocompatible, sterilizable, and non-corrosive. We expect that the newly designed mechanical culture system will increase our understanding on the regulatory role of direct mechanical pressure on the metabolic activities of chondrocytes.

journal_name

J Biomech

journal_title

Journal of biomechanics

authors

Steinmeyer J

doi

10.1016/s0021-9290(97)00040-7

subject

Has Abstract

pub_date

1997-08-01 00:00:00

pages

841-5

issue

8

eissn

0021-9290

issn

1873-2380

pii

S0021929097000407

journal_volume

30

pub_type

杂志文章

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