Abstract：
:Cerebral vasculature is several orders of magnitude stiffer than the brain tissue. However, only a handful of studies have investigated its potential stiffening effect on dynamic brain strains; yet, they report contradictory findings. Here, we reanalyze the cerebrovascular stiffening effect by incorporating vasculature derived from the latest neuroimaging atlases into a re-meshed Worcester Head Injury Model using an embedded element method. Regional brain strains with and without vasculature were simulated using a reconstructed, predominantly sagittal head impact. Using the two previously adopted linear or non-linear vessel material models, we reproduced the earlier conflicting results (~40% vs. ~1-6% in regional strain reductions). Nevertheless, with refitted non-linear material models chosen to represent the average dynamic tension behaviors of arteries and veins, respectively, inclusion of vasculature reduced regional brain strains by ~13-36% relative to the baselines without vasculature. Compared to the whole brain baseline response, inclusion of vasculature led to an element-wise linear regression slope of 0.8 and a Pearson correlation coefficient of 0.8. The vascular stiffening effect appears mild for the whole brain but more significant locally, which should not be ignored in head injury models. Nevertheless, more work is necessary to investigate the cerebrovascular mechanical behaviors and loading environment to allow for more biofidelic modeling of the brain in the future.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Zhao W,Ji Sdoi
10.1016/j.jbiomech.2020.109732subject
Has Abstractpub_date
2020-05-07 00:00:00pages
109732eissn
0021-9290issn
1873-2380pii
S0021-9290(20)30148-2journal_volume
104pub_type
杂志文章abstract：:The effect of non-habitual physical activity on bone architecture in the rat humeral shaft was examined. Two groups of rats were trained to swim for 1 h a day, for 20 weeks, at two training levels. The control group consisted of sedentary rats. Parameters of cross-sectional bone morphology (cross-section areas, princi...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(89)90068-7
更新日期：1989-01-01 00:00:00
abstract：:Accidentology data showed that liver is often injured in car crashes; three types of injuries occur: hematoma, laceration and vessel failure. This paper focuses on surface laceration, which involves liver capsule and hepatic parenchyma. Liver capsule behavior has been studied but its failure properties are still uncle...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2010.03.038
更新日期：2010-08-10 00:00:00
abstract：:Rapid force generation across submaximal levels has been evaluated with the rate of force development scaling factor (RFD-SF) in different isometric tasks, while such measurement was still not verified in dynamic tasks. Our study was designed to evaluate the feasibility of the RFD-SF in dynamic drop jump (DJ) task (RF...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2020.109980
更新日期：2020-09-18 00:00:00
abstract：:Mechanical hysteresis in tendons has traditionally been quantified from tensile testing of isolated specimens. Limitations associated with tendon displacement measurement and clamping, and uncertainties as to whether in vitro material represents intact tendon function necessitate measuring hysteresis under in vivo con...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(00)00130-5
更新日期：2000-12-01 00:00:00
abstract：:Incomplete stent apposition (ISA, also known as malapposition) is a complication that affects day-to-day coronary stenting procedures. ISA is more prominent in complex arterial geometries, such as curvature, asa result of the limited conformability of coronary stents. These malapposed struts disturb the otherwise near...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2017.09.016
更新日期：2017-10-03 00:00:00
abstract：:Earlier experimental and finite element studies notwithstanding, the load transfer and stress distribution in the pelvic bone and the acetabulum in normal conditions are not well understood. This hampers the development of orthopaedic reconstruction methods. The present study deals with more precise finite element ana...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(94)00125-n
更新日期：1995-06-01 00:00:00
abstract：:Anterior cruciate ligament (ACL) injury can result in failure to return to pre-injury activity levels and future osteoarthritis predisposition. Single leg hop is used in late rehabilitation to evaluate recovery and inform treatment but biomechanical understanding of this activity is insufficient. This study investigat...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2013.11.046
更新日期：2014-02-07 00:00:00
abstract：:The purpose of this investigation was to determine how the moment arms and architecture of the wrist muscles influence their isometric moment-generating characteristics. A three-dimensional computer graphic model was developed that estimates the moment arms, maximum isometric forces, and maximum isometric flexion-exte...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(97)00015-8
更新日期：1997-07-01 00:00:00
abstract：:Sphenodon, a lizard-like reptile, is the only living representative of a group that was once widespread at the time of the dinosaurs. Unique jaw mechanics incorporate crushing and shearing motions to breakdown food, but during this process excessive loading could cause damage to the jaw joints and teeth. In mammals li...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2010.08.001
更新日期：2010-12-01 00:00:00
abstract：:This work describes a dynamic model of the low back that incorporates extensive anatomical detail of the musculo-ligamentous-skeletal system to predict the load time histories of individual tissues. The dynamic reaction moment about L4/L5 was determined during lateral bending from a linked-segment model. This reaction...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(92)90259-4
更新日期：1992-04-01 00:00:00
abstract：:Increased knee flexion during stance is a common gait deviation in the child with cerebral palsy (CP), with distal hamstring lengthening surgeries being an accepted course of treatment. Post-operatively, improvements in gait kinematics have been reported, however little change is noted in the patterns of muscle activi...
journal_title：Journal of biomechanics
pub_type： 临床试验,杂志文章
doi：10.1016/j.jbiomech.2007.01.001
更新日期：2007-01-01 00:00:00
abstract：:A finite-element micromechanics model for Haversian cortical bone tissue has been developed and studied. The model is an extension of two-dimensional micromechanics techniques for fiber-reinforced composite materials. Haversian systems, or secondary osteons, are considered to be the fiber component, and interstitial l...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(92)90095-i
更新日期：1992-05-01 00:00:00
abstract：:We compare the predictions of the differential equation form of a class of bone-density stress adaptation models with their associated discrete-time computational algorithms. Although our considerations apply to the class of adaptation models based on bulk or apparent bone-density remodeling, we focus attention on a p...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(05)80007-7
更新日期：1993-09-01 00:00:00
abstract：:Stationary cycling is typically recommended following total knee arthroplasty (TKA) operations. However, knee joint biomechanics during cycling remains mostly unknown for TKA patients. Biomechanical differences between the replaced and non-replaced limb may inform applications of cycling in TKA rehabilitation. The pur...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2020.110111
更新日期：2021-01-22 00:00:00
abstract：:Baropodometry and multi-segmental foot kinematics are frequently employed to obtain insight into the mechanics of the foot-ground interaction in both basic research and clinical settings. However, nothing hitherto has been reported on the full integration of kinematics with baropodometric parameters, and only a few st...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2014.05.014
更新日期：2014-08-22 00:00:00
abstract：:Adverse wall shear stress (WSS) patterns are known to play a key role in the localisation, formation, and progression of intracranial aneurysms (IAs). Complex region-specific and time-varying aneurysmal WSS patterns depend both on vascular morphology as well as on variable systemic flow conditions. Computational fluid...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2016.10.005
更新日期：2016-12-08 00:00:00
abstract：:Throughout life, bone is continuously turning over by the well-regulated processes of bone formation and resorption. Everyday activities damage bone, and this damage is normally repaired in a continuous remodelling process. When an imbalance in this remodelling process occurs, bones may become more susceptible to frac...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(00)00215-3
更新日期：2001-04-01 00:00:00
abstract：:Heart valves induce flow disturbances which play a role in blood cell activation and damage, but questions of the magnitude and spatial distribution of fluid stresses (wall shear stress and turbulent stress) cannot be readily addressed with current experimental techniques. Therefore, a numerical simulation procedure f...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(94)90015-9
更新日期：1994-04-01 00:00:00
abstract：:A general theory is described for deriving the mechanical effect of muscles with large attachment sites. In a cadaver experiment the complete attachment sites and bundle distribution of 16 muscles of the shoulder mechanism were recorded. These data were used to calculate the mechanical effect, i.e. the resulting force...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(91)90007-a
更新日期：1991-01-01 00:00:00
abstract：:This investigation was designed to test the validity and reliability of a new measure of inversion/eversion ankle stiffness on a unique medial/lateral swaying cradle device utilizing a test/retest with comparison to a known standard. Ankle stiffness is essential to maintaining joint stability. Most ankle injuries occu...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2005.12.007
更新日期：2007-01-01 00:00:00
abstract：:Hammocks and cradles have long been appreciated, but in a very limited way. Aside from being emotionally soothing the devices affect the skin and all deep body components. While structurally simple they are functionally quite sophisticated and could very well affect the pattern of health care across the board--acute, ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(84)90089-7
更新日期：1984-01-01 00:00:00
abstract：:Muscle fatigue and recovery are complex processes influencing muscle force generation capacity. While fatigue reduces this capacity, recovery acts to restore the unfatigued muscle state. Many factors can potentially affect muscle recovery, and among these may be a task dependency of recovery following an exercise. How...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2016.11.061
更新日期：2017-01-25 00:00:00
abstract：:The diagonal limb support pattern at trot provides pitch and roll stability, but little is known about the control of moments about the centre of mass (COM) in horses. Correct COM location is critical in the calculation of pitching moments. The objectives were to determine the effect of COM location on pitching moment...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2014.02.024
更新日期：2014-04-11 00:00:00
abstract：:Diabetes mellitus, which results from a failure of the endocrine system to control blood glucose levels within normal limits, affects approximately 15% of the population over the age of 65 in developed countries. Between 20-50% of people with diabetes for more than 10 years will experience symmetrical distal sensory n...
journal_title：Journal of biomechanics
pub_type： 杂志文章,评审
doi：10.1016/0021-9290(93)90077-r
更新日期：1993-01-01 00:00:00
abstract：:Previous studies on cats walking backward have indicated that they adopt a presumably adaptive posture characterized by extreme dorsiflexion of the lumbar spine. Because humans do not show any marked postural changes during backward walking, we questioned whether the posture exhibited by cats during backward walking w...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(00)00071-3
更新日期：2000-08-01 00:00:00
abstract：:We have developed a musculoskeletal model of the human lower extremity for computer simulation studies of musculotendon function and muscle coordination during movement. This model incorporates the salient features of muscle and tendon, specifies the musculoskeletal geometry and musculotendon parameters of 18 musculot...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(90)90349-8
更新日期：1990-01-01 00:00:00
abstract：:Proper function of the female pelvic floor requires intact pelvic floor muscles (PFMs). The prevalence of pelvic floor disorders (PFDs) increases substantially with age, in part due to clinically identified deterioration of PFM function with age. However, the etiology of this decline remains largely unknown. We previo...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2019.109436
更新日期：2020-01-02 00:00:00
abstract：:Essential tremor (ET) is a common tremor disorder affecting postural/action tremor of the upper extremities and midline. Recent research revealed a cerebellar-like deficit during tandem gait in persons with ET, though spatiotemporal variability during normal gait in ET has been relatively ignored. The first purpose of...
journal_title：Journal of biomechanics
pub_type： 临床试验,杂志文章
doi：10.1016/j.jbiomech.2013.07.039
更新日期：2013-10-18 00:00:00
abstract：:Previous studies of compensatory stepping, in response to postural perturbation, have focussed on forward or backward stepping; however, the ability to step in other directions is of equal functional importance, since the perturbations encountered in daily life may often include a lateral component. The primary object...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(95)00053-4
更新日期：1996-03-01 00:00:00
abstract：:The motor module hypothesis in motor control proposes that the nervous system can simplify the problem of controlling a large number of muscles in human movement by grouping muscles into a smaller number of modules. Here, we tested one prediction of the modular organization hypothesis by examining whether there is pre...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2016.02.006
更新日期：2016-03-21 00:00:00
