Abstract：
:Incomplete stent apposition (ISA, also known as malapposition) is a complication that affects day-to-day coronary stenting procedures. ISA is more prominent in complex arterial geometries, such as curvature, asa result of the limited conformability of coronary stents. These malapposed struts disturb the otherwise near-wall laminar blood flow and form a micro-recirculation environment. The micro-recirculation environment is often associated with low wall shear stress (WSS) and upsets the delicate balance of vascular biology, providing possible nidus for thrombosis and restenosis. In this study, a three-dimensional (3D) stent model was virtually deployed into an idealised curved coronary artery. Computational fluid dynamics (CFD) simulations were carried out to systematically analyse the haemodynamic effects of increasing maximum ISA distances, ranging from 180 (moderate), 400 (intermediate) to 910μm (severe) in an artery with decreasing radius of curvature (ROC). Micro-recirculations around both proximal and distal malapposed struts become more pronounced as compared to fully-apposed struts. The accompanying areas of low temporally-averaged WSS (AL-TAWSS) can increase twofold compared to the fully-apposed condition. Furthermore, substantial regions (∼5.2% and 9.0%) of AL-TAWSS are detached from the distal end of the malapposed struts in both moderate and intermediate cases respectively. Malapposed stents also induce more variation of TAWSS at the inner bend of the artery. At the stent surface, maximum WSS increases threefold from the fully-apposed case to intermediate ISA. High WSS on the strut surface is known to activate platelets which when exposed to the micro-recirculation environment may lead to their deposition and thrombosis.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Chen WX,Poon EKW,Thondapu V,Hutchins N,Barlis P,Ooi Adoi
10.1016/j.jbiomech.2017.09.016subject
Has Abstractpub_date
2017-10-03 00:00:00pages
164-173eissn
0021-9290issn
1873-2380pii
S0021-9290(17)30481-5journal_volume
63pub_type
杂志文章abstract：:The structural properties of tendons and ligaments are integral to their ability to function effectively in vivo and are determined from both the geometrical form and material properties. Many studies of tendon and ligament include a mechanical assessment of the structure in vitro. However, to determine the material p...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2004.05.003
更新日期：2005-03-01 00:00:00
abstract：:Accurate measurement of six-degrees-of-freedom in-vivo kinematics of the total hip arthroplasty (THA) is essential in gaining insights into in-vivo THA performance. The objective of this study was to validate a novel dual fluoroscopy imaging system (DFIS) for determination of the THA kinematics using both in-vitro and...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2013.02.010
更新日期：2013-04-26 00:00:00
abstract：:Previous models to predict breast movement whilst performing physical activities have, erroneously, assumed uniform elasticity within the breast. Consequently, the predicted displacements have not yet been satisfactorily validated. In this study, real time motion capture of the natural vibrations of a breast that foll...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2017.11.027
更新日期：2018-01-23 00:00:00
abstract：:The purpose of this study was to propose and validate a new simple method for calculation of center of mass work during field running, in order to avoid the use of costly and inconvenient measurement devices. This method relies on spring-mass model and measurements of average horizontal velocity, and contact and fligh...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2019.109369
更新日期：2019-12-03 00:00:00
abstract：:Motion capture systems are widely used to measure human kinematics. Nevertheless, users must consider system errors when evaluating their results. Most validation techniques for these systems are based on relative distance and displacement measurements. In contrast, our study aimed to analyse the absolute volume accur...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2018.04.009
更新日期：2018-06-06 00:00:00
abstract：:The three-dimensional trajectory of the body's centre of mass (COM) is useful to determine a number of biomechanical outcomes in running research. Previous studies have used the COM to calculate measures such as overstriding, vertical stiffness, and vertical oscillation. The COM is traditionally computed using the seg...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2020.109886
更新日期：2020-07-17 00:00:00
abstract：:The accurate assessment of the Achilles tendon cross-sectional area (CSA) is a crucial prerequisite to investigate tendon adaptation and to calculate the tendon Young׳s modulus. Besides magnetic resonance imaging (MRI), ultrasonography emerged as an alternative imaging technique. The purpose of the present study was t...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2016.07.002
更新日期：2016-09-06 00:00:00
abstract：:The successful development of early-stage cartilage and meniscus repair interventions in the knee requires biomechanical and biotribological understanding of the design of the therapeutic interventions and their tribological function in the natural joint. The aim of this study was to develop and validate a porcine kne...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2015.07.043
更新日期：2015-09-18 00:00:00
abstract：:The objective of this study was to calculate stresses in bone tissue surrounding uncoupled and splinted implants that are induced by a bite force applied to the mandible and to determine whether the number of mandibular overdenture supporting implants in mandibular bone influence the stress distribution. A human adult...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2014.10.022
更新日期：2015-01-02 00:00:00
abstract：:Locomotion of the horse is simulated using a mathematical model based on rigid body dynamics. A general method to generate the equations of motion for a two-dimensional rigid body model with an arbitrary number of hinge joints is presented and a numerical solution method, restricted to tree-structured models, is descr...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(89)90182-6
更新日期：1989-01-01 00:00:00
abstract：:None of the physical testing, nor the goniometers currently used to assess upper limb function have a high validity, sensitivity or reliability. The reachable workspace, i.e. the area covered by the farthest points a subject can reach by hand without moving his/her body, shows promise but has yet to be validated, part...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2017.12.010
更新日期：2018-02-08 00:00:00
abstract：:Although a significant proportion of patient falls occur during egress from the hospital bed, the biomechanical adaptations during egress from different bed heights are still largely unknown. The purpose of this study was to evaluate the effect of hospital bed height on natural transition during egress in patients wit...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2020.110116
更新日期：2021-01-22 00:00:00
abstract：:A pair of finite element models has been employed to study the interaction of blood flow with the operation of the aortic valve. A three-dimensional model of the left ventricle with applied wall displacements has been used to generate data for the spatially and time-varying blood velocity profile across the aortic ape...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2004.10.038
更新日期：2006-01-01 00:00:00
abstract：:The ability to visualize and interpret high dimensional time-series data will be critical as wearable and other sensors are adopted in rehabilitation protocols. This study proposes a latent space representation of high dimensional time-series data for data visualization. For that purpose, a deep learning model called ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2020.109684
更新日期：2020-04-16 00:00:00
abstract：:The measurement of relative motion between two moving bones is commonly accomplished for in vitro studies by attaching to each bone a series of either passive or active markers in a fixed orientation to create a rigid body (RB). This work determined the accuracy of motion between two RBs using an Optotrak optical moti...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2006.01.017
更新日期：2007-01-01 00:00:00
abstract：:Sphenodon, a lizard-like reptile, is the only living representative of a group that was once widespread at the time of the dinosaurs. Unique jaw mechanics incorporate crushing and shearing motions to breakdown food, but during this process excessive loading could cause damage to the jaw joints and teeth. In mammals li...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2010.08.001
更新日期：2010-12-01 00:00:00
abstract：:Patterns in cell adhesion molecule expression by endothelial cells may play a role in atherogenesis. Previous studies have shown dependence of intracellular adhesion molecule-1 (ICAM-1) expression in human umbilical vein endothelial cells (HUVEC) on shear stress and have indirectly linked ICAM-1 expression to spatial ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2005.02.002
更新日期：2006-01-01 00:00:00
abstract：:This article describes a method to simulate fusion of morselized cancellous bone. The morselized cancellous bone is mixed with an epoxy adhesive, in empirically determined proportions. The mixture is then impacted into a construct. When the epoxy cures, the morselized material fuses into a cohesive, contiguous structu...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(01)00032-x
更新日期：2001-06-01 00:00:00
abstract：:The topographical distributions of the zonal properties of articular cartilage over the medial tibia from an experimental osteoarthritis (OA) model were evaluated as a function of external loading by microscopic Magnetic Resonance Imaging (µMRI). T2 relaxation times and cartilage thicknesses were measured at 17.6 µm r...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2015.08.011
更新日期：2015-10-15 00:00:00
abstract：:In this article, the tensile properties of gastric wall were investigated by using biomechanical test and theoretical analysis. The samples of porcine stomach strips from smaller and greater curvature of the stomach were cut in longitudinal and circumferential direction, respectively. The loading-unloading, stress rel...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2014.12.048
更新日期：2015-02-26 00:00:00
abstract：:Human runners adjust the stiffness of their stance leg to accommodate surface stiffness during steady state running. This adjustment allows runners to maintain similar center of mass movement (e.g., ground contact time and stride frequency) regardless of surface stiffness. When runners encounter abrupt transitions in ...
journal_title：Journal of biomechanics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0021-9290(99)00078-0
更新日期：1999-08-01 00:00:00
abstract：:A challenging aspect of subject specific musculoskeletal modeling is the estimation of muscle parameters, especially optimal fiber length and tendon slack length. In this study, the method for scaling musculotendon parameters published by Winby et al. (2008), J. Biomech. 41, 1682-1688, has been reformulated, generaliz...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2015.11.006
更新日期：2016-01-25 00:00:00
abstract：:Computational simulations of tissue differentiation have been able to capture the main aspects of tissue formation/regeneration observed in animal experiments-except for the considerable degree of variability reported. Understanding and modelling the source of this variability is crucial if computational tools are to ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2011.02.003
更新日期：2011-04-07 00:00:00
abstract：:A computer-controlled mechanical culture system was designed to investigate the interaction between mechanical stimuli and the metabolism of articular cartilage. The main features of this system include the following capabilities: (1) Accurately controlled static, permanent cyclic or intermittent cyclic mechanical loa...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(97)00040-7
更新日期：1997-08-01 00:00:00
abstract：:We developed an intravaginal instrumented probe (covered with a 10×10 matrix of capacitive sensors) for assessing the three-dimensional (3D) spatiotemporal pressure profile of the vaginal canal. The pressure profile was compared to the pelvic floor (PF) digital assessment, and the reliability of the instrument and rep...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2017.04.035
更新日期：2017-06-14 00:00:00
abstract：:Pulsatile flow in abdominal aortic aneurysm (AAA) models has been examined in order to understand the hemodynamics that may contribute to growth of an AAA. The model studies were conducted by experiments (flow visualization and laser Doppler velocimetry) and by numerical simulation using physiologically realistic rest...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(99)00134-7
更新日期：1999-12-01 00:00:00
abstract：:Biomechanical models may aid in improving diagnosis and treatment of wrist joint disorders. As input, geometrical information is required for model development. Previous studies acquired some elements of the average wrist joint geometry. However, there is a close geometric functional match between articulating surface...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2009.11.003
更新日期：2010-03-22 00:00:00
abstract：:Musculoskeletal simulations of human movement commonly use Hill muscle models to predict muscle forces, but their sensitivity to model parameter values is not well understood. The purpose of this study was to evaluate muscle model sensitivity to perturbations in 14 Hill muscle model parameters in forward dynamic simul...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2005.06.005
更新日期：2006-01-01 00:00:00
abstract：:Wall shear stress distribution in the carotid siphon, which is a multiple curved segment of the internal carotid artery, is investigated numerically under physiological flow conditions. The computer simulation of flow through the model segment is based on the time-dependent, three-dimensional Navier-Stokes equations, ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(88)90203-5
更新日期：1988-01-01 00:00:00
abstract：:The in situ longitudinal strain of canine and porcine aortas was investigated. Marks of black water-resistant ink were placed on the aortas and the axial lengths between the marks were measured in situ and in vitro. When the aortas were cut, the retraction was measured and described by the stretch ratio, which is defi...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(94)00091-h
更新日期：1995-05-01 00:00:00
