Abstract:
:Musculoskeletal simulations of human movement commonly use Hill muscle models to predict muscle forces, but their sensitivity to model parameter values is not well understood. The purpose of this study was to evaluate muscle model sensitivity to perturbations in 14 Hill muscle model parameters in forward dynamic simulations of running and walking by varying each by +/-50%. Three evaluations of the muscle model were performed based on: (1) calculating the sensitivity of the muscle model only, (2) determining the continuous partial derivatives of the muscle equations with respect to each parameter, and (3) evaluating the effects on the running and walking simulations. Model evaluations were found to be very sensitive (percent change in outputs greater than parameter perturbation) to parameters defining the series elastic component (tendon), force-length curve of the contractile element and maximum isometric force. For some parameters, the range of literature values was larger than the model sensitivity. Model evaluations were insensitive to parameters defining the parallel elastic element, force-velocity curve of the contractile element and muscle activation time constants. The derivative method provided similar results, but also provided a generic, continuous equation that can easily be applied to other motions. The sensitivities of the running and walking simulations were reduced compared to the sensitivity of the muscle model alone. Results demonstrate the importance of evaluating sensitivity of a musculoskeletal simulation in a controlled manner and provide an indication of which parameters must be selected most carefully based on the sensitivity of a given movement.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Scovil CY,Ronsky JLdoi
10.1016/j.jbiomech.2005.06.005keywords:
subject
Has Abstractpub_date
2006-01-01 00:00:00pages
2055-63issue
11eissn
0021-9290issn
1873-2380pii
S0021-9290(05)00277-0journal_volume
39pub_type
杂志文章abstract::A computer-controlled mechanical culture system was designed to investigate the interaction between mechanical stimuli and the metabolism of articular cartilage. The main features of this system include the following capabilities: (1) Accurately controlled static, permanent cyclic or intermittent cyclic mechanical loa...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/s0021-9290(97)00040-7
更新日期:1997-08-01 00:00:00
abstract::Healthy humans display a preference for walking at a stride frequency dependent on the inertial properties of their legs. Walking at preferred stride frequency (PSF) is predicted to maximize local dynamic stability, whereby sensitivity to intrinsic perturbations arising from natural variability inherent in biological ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2013.10.012
更新日期:2014-01-03 00:00:00
abstract::Bilateral asymmetry in gallop stride limb contact patterns of four Quarter Horse fillies was documented by high-speed cinematography. Horses were filmed with rider by two cameras simultaneously while galloping along a straightaway. Even though signaled for each gallop lead an equivalent number of times, horses frequen...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/0021-9290(87)90285-5
更新日期:1987-01-01 00:00:00
abstract::In this study, human tibia plateaus with the meniscus removed were impacted on various regions of the plateau surface via a drop test using a 5mm indenter. Osteochondral blocks containing the failure site were then extracted, chemically fixed, dehydrated, gold-particle coated, and sent for X-ray micro-CT imaging to ob...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2008.01.033
更新日期:2008-01-01 00:00:00
abstract::To study the effect of pressure changes on the opening angle of arteries in organ culture, tubular segments of porcine common carotid arteries were cultured with pulsatile flow perfusion under hypertensive (150+/-20 mmHg), normotensive (100+/-20 mmHg), or hypotensive (30+/-10 mmHg) pressure while maintaining the arter...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2005.08.003
更新日期:2006-01-01 00:00:00
abstract::The primary aim of this work is to investigate the potential of nonlinear ultrasound for microdamage detection in human bone. Microdamage evaluation in human bone is of great importance, because it is considered a significant parameter for characterizing fracture risk. Experiments employing nonlinear acoustic vibro-mo...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2008.12.018
更新日期:2009-03-26 00:00:00
abstract::When recovering balance from a lateral perturbation, younger adults tend to stabilize balance with a single lateral sidestep while older adults often take multistep responses. Using multiple steps to recover balance is consistently associated with increased fall risk, altered body center of mass (CoM) control and inst...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2020.110161
更新日期:2021-01-04 00:00:00
abstract::Mechanical testing of soft tissues would ideally rely on using fresh specimens. In the event that fresh tissues are not readily available, alternative measures, such as storing fresh specimens at -80 °C, could be considered. Previous studies have shown that changes in the mechanical properties of the tissues due to fr...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2019.109462
更新日期:2020-01-02 00:00:00
abstract::Unnatural dynamics of the notorious vortex in the left ventricle is often associated with cardiac disease. Understanding how different cardiac diseases alter the flow physics in the left ventricle may therefore provide a powerful tool for disease detection. In this work, the fluid dynamics in the left ventricle subjec...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2018.07.023
更新日期:2018-09-10 00:00:00
abstract::Tissue scaffolds are typically designed and fabricated to match native bone properties. However, it is unclear if this would lead to the best tissue ingrowth outcome within the scaffold as neo-tissue keeps changing the stiffness of entire construct. This paper presents a numerical method to address this issue for desi...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2010.02.020
更新日期:2010-06-18 00:00:00
abstract::Despite significant evidence regarding the increased risk of cartilage degeneration due to traumatic injuries to joints, there is still a lack of understanding of the mechanisms underlying osteoarthritis development following a joint injury. Injuries in knee cartilage are often characterized by lesions or tears. In ad...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2020.109970
更新日期:2020-09-18 00:00:00
abstract::Although a significant proportion of patient falls occur during egress from the hospital bed, the biomechanical adaptations during egress from different bed heights are still largely unknown. The purpose of this study was to evaluate the effect of hospital bed height on natural transition during egress in patients wit...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2020.110116
更新日期:2021-01-22 00:00:00
abstract::In human walking, the center of mass motion is similar to an inverted pendulum. Viewing double support as a transition from one inverted pendulum to the next, we hypothesized that the leading leg performs negative work to redirect the center of mass velocity, while simultaneously, the trailing leg performs positive wo...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/s0021-9290(01)00169-5
更新日期:2002-01-01 00:00:00
abstract::Friction between the prosthetic head and acetabular cup increases the temperature in hip implants during activities like walking. A hip endoprosthesis was instrumented with sensors to measure the joint contact forces and the temperature distribution along the entire length of the titanium implant. Sensors and two indu...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/s0021-9290(99)00110-4
更新日期:1999-10-01 00:00:00
abstract::The study analyses the two-dimensional distribution of surface mechanomyographic (MMG) signal generated by the activation of single motor units located in three transverse positions in the tibialis anterior muscle. In 12 healthy volunteers, surface MMG signals were recorded from the tibialis anterior muscle with a 3 x...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2008.07.007
更新日期:2008-09-18 00:00:00
abstract::A structural model was developed to explain sarcomere shortening at the expense of tendon lengthening in the frog semitendinosis (ST) muscle-tendon system. The model was based on the data of Lieber et al. [Am. J. Physiol. 261, C86-C92 (1991)], who determined the relationship between the sarcomere length, tendon load (...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/0021-9290(92)90261-x
更新日期:1992-04-01 00:00:00
abstract::Interstitial fluid flow has been shown to affect the organization and behavior of cells in 3D environments in vivo and in vitro, yet the forces driving such responses are not clear. Due to the complex architecture of the extracellular matrix (ECM) and the difficulty of measuring fluid flow near cells embedded in it, t...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2006.06.023
更新日期:2007-01-01 00:00:00
abstract::The purpose of this study was to examine two hypotheses: (a) during voluntary and electrically induced isometric contractions the moments measured at the dynamometer are different from the resultant moments in the same plane around the ankle joint and (b) at a given resultant moment during electrically induced isometr...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2004.04.027
更新日期:2005-04-01 00:00:00
abstract::Blood platelets when activated are involved in the mechanisms of hemostasis and thrombosis, and their migration toward injured vascular endothelium necessitates interaction with red blood cells (RBCs). Rheology co-factors such as a high hematocrit and a high shear rate are known to promote platelet mass transport towa...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2017.06.044
更新日期:2017-08-16 00:00:00
abstract::The biomechanical characteristics of bone tissue and its cells under mechanical stress are significant for bone biomechanics research, but the mechanism of mechanotransduction is still unknown. It has been established that the actin cytoskeleton of osteoblasts plays an important role in this process. However, the stru...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2008.08.010
更新日期:2008-11-14 00:00:00
abstract::Simple models are widely used to understand the mechanics of human walking. The optimization-based minimal biped model and spring-loaded-inverted-pendulum (SLIP) model are two popular models that can achieve human-like walking patterns. However, ground reaction forces (GRF) from these two models still deviate from exp...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2019.04.028
更新日期:2019-06-11 00:00:00
abstract::Controlling dynamic interactions between the lower limb and ground is important for skilled locomotion and may influence injury risk in athletes. It is well known that female athletes sustain anterior cruciate ligament (ACL) tears at higher rates than male athletes, and exhibit lower extremity biomechanics thought to ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2013.10.038
更新日期:2014-01-22 00:00:00
abstract::Improper activation of the quadriceps muscles vastus medialis (VM) and vastus lateralis (VL) has been implicated in the development of patellofemoral pain (PFP). This explanation of PFP assumes that VM and VL produce opposing mediolateral forces on the patella. Although studies have provided evidence for opposing acti...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2018.09.007
更新日期:2018-11-16 00:00:00
abstract::In order to provide physical information supporting the clinical use of flow mapping, an in vitro model was designed to measure the velocity fields in a pulsatile hydraulic turbulent jet. We used a peak velocity ranging from 2.5 to 5.5 m.s-1, an orifice diameter ranging from 5.8 to 11.3 mm and confined the jet in a re...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/0021-9290(90)90367-c
更新日期:1990-01-01 00:00:00
abstract::The purpose of this study was to investigate whether athletic and nonathletic manual wheelchair users (MWU) display differences in kinetic and kinematic variables during daily wheelchair propulsion. Thirty-nine manual wheelchair users (athletic n = 25; nonathletic n = 14) propelled their own daily living wheelchair on...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2020.109725
更新日期:2020-05-07 00:00:00
abstract::Individuals with spastic cerebral palsy (SCP) exhibit restricted joint range of motion and increased joint stiffness due to structural alterations of their muscles. Little is known about which muscle-tendon structures are responsible for these alterations. The aim of this study was to compare the passive mechanics of ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2011.06.008
更新日期:2011-09-02 00:00:00
abstract::In this study the investigations made on about 50 trunk tissue densities are described. They were performed on ten cadavers of both sexes within 24 h of the moment of death. They were 20-40 yr old. The weight of each tissue was measured on a laboratory scale and the volume by placing the tissue in a pycnometer filled ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/0021-9290(90)90360-f
更新日期:1990-01-01 00:00:00
abstract::Animal models of ventricular tachypacing (VTP) have been successfully used to reproduce the relevant features observed in patients with atrial fibrillation, such as increased atrial pressure and volume, ion-channel alterations and fibrosis. After performing VTP on a healthy Yorkshire pig, we measured an increase in vo...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2011.09.003
更新日期:2011-11-10 00:00:00
abstract::The analysis of in-field biomechanics data typically requires the identification of foot contact. Existing techniques to identify foot contact using accelerometers offer a viable option for identifying foot contact in the field. However, these techniques often require the placement of additional accelerometers or the ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2020.109768
更新日期:2020-05-22 00:00:00
abstract::To better protect soldiers from blast threat, that principally affect air-filled organs such a lung, it is necessary to develop an adapted injury criterion and, prior to this, to evaluate the response of a biological model against that threat. The objective of this study is to provide some robust data to quantify the ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2017.10.012
更新日期:2017-12-08 00:00:00