Abstract：
:Blood platelets when activated are involved in the mechanisms of hemostasis and thrombosis, and their migration toward injured vascular endothelium necessitates interaction with red blood cells (RBCs). Rheology co-factors such as a high hematocrit and a high shear rate are known to promote platelet mass transport toward the vessel wall. Hemodynamic conditions promoting RBC aggregation may also favor platelet migration, particularly in the venous system at low shear rates. The aim of this study was to confirm experimentally the impact of RBC aggregation on platelet-sized micro particle migration in a Couette flow apparatus. Biotin coated micro particles were mixed with saline or blood with different aggregation tendencies, at two shear rates of 2 and 10s-1 and three hematocrits ranging from 20 to 60%. Streptavidin membranes were respectively positioned on the Couette static and rotating cylinders upon which the number of adhered fluorescent particles was quantified. The platelet-sized particle adhesion on both walls was progressively enhanced by increasing the hematocrit (p<0.001), reducing the shear rate (p<0.001), and rising the aggregation of RBCs (p<0.001). Particle count was minimum on the stationary cylinder when suspended in saline at 2s-1 (57±33), and maximum on the rotating cylinder at 60% hematocrit, 2s-1 and the maximum dextran-induced RBC aggregation (2840±152). This fundamental study is confirming recent hypotheses on the role of RBC aggregation on venous thrombosis, and may guide molecular imaging protocols requiring injecting active labeled micro particles in the venous flow system to probe human diseases.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Guilbert C,Chayer B,Allard L,Yu FTH,Cloutier Gdoi
10.1016/j.jbiomech.2017.06.044subject
Has Abstractpub_date
2017-08-16 00:00:00pages
26-33eissn
0021-9290issn
1873-2380pii
S0021-9290(17)30354-8journal_volume
61pub_type
杂志文章abstract：:Nowadays in various daily, occupational and training activities, there are many occasions with forces supported in hands acting at various magnitudes, elevations, and orientations with substantial horizontal components. In this work, we aim to compute trunk muscle forces, stability, and spinal loads under pulling exte...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2015.09.036
更新日期：2016-04-11 00:00:00
abstract：:Bone mineral density (BMD) measurements from Dual-energy X-ray Absorptiometry (DXA) alone cannot account for all factors associated with the risk of hip fractures. For example, the inhomogeneity of bone mineral density in the hip region also contributes to bone strength. In the stochastic assessment of bone inhomogene...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2015.01.030
更新日期：2015-04-13 00:00:00
abstract：:A new technique to study the mechanical properties of collagen lattices or dermal equivalents is described. With the help of the load-extension curve obtained with a uniaxial traction apparatus, a stiffness modulus varying from 0.06 to 1 MPa is calculated from the studied parameters (duration of culture, collagen and ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(92)90250-5
更新日期：1992-01-01 00:00:00
abstract：:Hyaline joint cartilage has only a limited potential for self-repair. Some of the published techniques for osteochondral defect therapy try to improve that potential. In this study, it was hypothesised that one of those surgical techniques, the crushed transplanted bone graft together with a collagen membrane, acceler...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2007.02.021
更新日期：2007-01-01 00:00:00
abstract：:The in situ longitudinal strain of canine and porcine aortas was investigated. Marks of black water-resistant ink were placed on the aortas and the axial lengths between the marks were measured in situ and in vitro. When the aortas were cut, the retraction was measured and described by the stretch ratio, which is defi...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(94)00091-h
更新日期：1995-05-01 00:00:00
abstract：:This study investigated the accuracy of the direct linear transformation (DLT) and non-linear transformation (NLT) methods of 3-D cinematography/videography. A comparison of standard DLT, extrapolated DLT, and NLT calibrations showed the standard (non-extrapolated) DLT to be the most accurate, especially when a large ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(95)00034-f
更新日期：1995-10-01 00:00:00
abstract：:Incisional hernia development is a significant complication after laparoscopic abdominal surgery. Intra-abdominal pressure (IAP) is known to initiate the extrusion of intestines through the abdominal wall, but there is limited data on the mechanics of IAP generation and the structural properties of rectus sheath. This...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2014.03.009
更新日期：2014-06-03 00:00:00
abstract：OBJECTIVE:This paper documents research that quantifies and describes the biomechanics of normal gait on inclined surfaces. DESIGN:Experimental, investigative. BACKGROUND:It is necessary to walk on inclined surfaces to negotiate the natural and built environments. Little research has been conducted on the biomechanic...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2005.07.025
更新日期：2006-01-01 00:00:00
abstract：:While measuring knee motion in all six degrees of freedom is important for understanding and treating orthopaedic knee pathologies, traditional motion capture techniques lack the required accuracy. A variety of model-based biplane fluoroscopy techniques have been developed with sub-millimeter accuracy. However, no stu...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2012.08.045
更新日期：2012-11-15 00:00:00
abstract：:A subject, who had undergone surgery to replace one hip joint and the proximal half of the femur with an instrumented titanium implant, performed brief exercises whilst simultaneous measurements were made of compressive axial force in the implant using short-range wireless telemetry, ground reactions using a Kistler f...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(96)00043-7
更新日期：1997-03-01 00:00:00
abstract：:In attempts to better understand the etiology of osteoarthritis, a debilitating joint disease that results in the degeneration of articular cartilage (AC) in synovial joints, researchers have focused on joint tribology, the study of joint friction, lubrication, and wear. Several different approaches have been used to ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2009.05.024
更新日期：2009-08-25 00:00:00
abstract：:Computer simulation of human masticatory dynamics requires specification of the jaw's mass properties. These are difficult to estimate, especially in living subjects. Here, we used calibrated computed tomography (CT) to determine the properties of eight osseous jaw specimens with adult dentitions. When the CT numbers ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(02)00057-x
更新日期：2002-07-01 00:00:00
abstract：:Determination of contact areas in diarthrodial joints is necessary for understanding the state of stress within the articular cartilage layers and the supporting bony structures. The present study describes the use of a stereophotogrammetry (SPG) system [Huiskes et al., J. Biomechanics 18, 559-570 (1985) and Ateshian ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(94)90038-8
更新日期：1994-01-01 00:00:00
abstract：:A finite element model was used to investigate the counter-intuitive experimental observation that some regions of the aponeuroses of a loaded and contracting muscle may shorten rather than undergo an expected lengthening. The model confirms the experimental findings and suggests that pennation angle plays a significa...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2010.01.005
更新日期：2010-05-07 00:00:00
abstract：:Rotator cuff tears (RCTs), the most common injury of the shoulder, are often accompanied by tears in the superior glenoid labrum. We evaluated whether superior humeral head (HH) motion secondary to RCTs and loading of the long head of the biceps tendon (LHBT) are implicated in the development of this associated superi...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2014.01.036
更新日期：2014-05-07 00:00:00
abstract：BACKGROUND:Dilation and dissection of aneurysmal ascending aortic tissues occur preferentially at the outer curvature of the vessel. In this study we hypothesize that the density and contractile properties of the vascular smooth muscle cells (VSMCs) of the pig ascending aorta (AA) are heterogeneous and could explain th...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2010.04.018
更新日期：2010-08-26 00:00:00
abstract：:Respiratory assessment and the biomechanical analysis of chest and abdomen motion during breathing can be carried out using motion capture systems. An advantage of this methodology is that it allows analysis of compartmental breathing volumes, thoraco-abdominal patterns, percentage contribution of each compartment and...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2018.05.036
更新日期：2018-07-25 00:00:00
abstract：:We recently demonstrated that a set of five functional muscle synergies were sufficient to characterize both hindlimb muscle activity and active forces during automatic postural responses in cats standing at multiple postural configurations. This characterization depended critically upon the assumption that the endpoi...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2007.09.012
更新日期：2008-01-01 00:00:00
abstract：:Although micromechanical finite-element models are being increasingly used to help interpret the results of bio-mechanical tests, there has not yet been a systematic study of the numerical errors and uncertainties that occur with these methods. In this work, finite-element models of human L1 vertebra have been used to...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(98)00108-0
更新日期：1998-10-01 00:00:00
abstract：:In this paper we present a study of the post valvular flow field on a new cardiovascular simulator including an elastic model of the aortic arch. Transverse and vertical two-dimensional velocity measurements are performed with an ultrasonic velocimeter. Two prosthetic heart valves are tested in the aortic position. Th...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(85)90054-5
更新日期：1985-01-01 00:00:00
abstract：:Topically applied microbicide gels can provide a self-administered and effective strategy to prevent sexually transmitted infections (STIs). We have investigated the interplay between vaginal tissue elasticity and the yield-stress of non-Newtonian fluids during microbicide deployment. We have developed a mathematical ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2015.01.049
更新日期：2015-06-25 00:00:00
abstract：:A conspicuous long-term consequence of hypertension is a thickening of the arterial wall, which many suggest returns the circumferential wall stress toward its normal value. This thickening results from an increase in smooth muscle and extracellular matrix, with the associated growth and remodeling processes depending...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(03)00178-7
更新日期：2003-11-01 00:00:00
abstract：:Abnormal femoral version is a deformity in the angle between the femoral neck and the transcondylar axis of the knee. Both femoral anteversion and retroversion alter passive and active rotation of the hip and are associated with intra-articular or extra-articular impingement. However, little is known about the effect ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2020.109891
更新日期：2020-08-26 00:00:00
abstract：OBJECTIVE:To test if the caudal acetabulum of the cat is unloaded at mid-stance as has been asserted. MATERIALS AND METHODS:A kinematic study of five healthy cats was performed to ascertain the mid-stance angle of the hip joint, and the orientation of the pelvis and femur. Femora and pelves from 10 feline cadavers wer...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2004.04.035
更新日期：2005-03-01 00:00:00
abstract：:The use of electromyographic measures, in concert with modeled or empirical representations of muscle physiology, is a common approach for estimation of muscle force. Existing models of the lumbar musculature have allowed model parameters to vary for an individual subject. While this approach improves apparent predict...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(98)00055-4
更新日期：1998-07-01 00:00:00
abstract：:The purpose of this study was to assess the interpersonal coordination during official male tennis matches in players of different skill levels. Players' trajectories of three levels (Juvenile, ATP-Future, ATP-250) were obtained using video-based tracking system. A vector coding technique was applied to obtain players...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2017.11.036
更新日期：2018-01-23 00:00:00
abstract：:A biomechanical model of the forearm, consisting of 61 muscle-tendon systems or tendons and 8 sections, is presented. The model can be used to calculate the muscle forces when resultant of the external forces and the motion is known. Calculations are based on constraints of muscle forces, joint forces, contact forces,...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(01)00009-4
更新日期：2001-05-01 00:00:00
abstract：:This study investigated the center of rotation (COR) of the intervertebral segments of the lower lumbar spine (L4-L5 and L5-S1 segments) in sagittal plane during a weight-lifting (3.6 kg in each hand) extension activity performed with the pelvis constrained. Seven healthy subjects were studied using a dual fluoroscopi...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2015.12.029
更新日期：2016-02-08 00:00:00
abstract：:Mechanical properties of skeletal muscles are often studied for controlled, electrically induced, maximal, or supra-maximal contractions. However, many mechanical properties, such as the force-length relationship and force enhancement following active muscle stretching, are quite different for maximal and sub-maximal,...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2005.12.002
更新日期：2007-01-01 00:00:00
abstract：:Here we present a study on the impact of assumptions on image-based hemodynamic simulations of healthy carotid bifurcations. In particular, we evaluate to which extent assumptions on blood rheology influence bulk flow features, driven by the fact that few studies have provided adequate insights into the influence of a...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2011.06.028
更新日期：2011-09-02 00:00:00
