Abstract：
:Tissue scaffolds are typically designed and fabricated to match native bone properties. However, it is unclear if this would lead to the best tissue ingrowth outcome within the scaffold as neo-tissue keeps changing the stiffness of entire construct. This paper presents a numerical method to address this issue for design optimization and assessment of tissue scaffolds. The elasticity tensors of two different types of bones are weighted by different multipliers before being used as the targets in scaffold design. A cost function regarding the difference between the effective elasticity tensor, calculated by the homogenization technique, and the target tensor, is minimized by using topology optimization procedure. It is found that different stiffnesses can lead to different remodeling results. The comparison confirms that bone remodeling is at its best when the scaffold elastic tensor matches or is slightly higher than the elastic properties of the host bone.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Sturm S,Zhou S,Mai YW,Li Qdoi
10.1016/j.jbiomech.2010.02.020subject
Has Abstractpub_date
2010-06-18 00:00:00pages
1738-44issue
9eissn
0021-9290issn
1873-2380pii
S0021-9290(10)00103-Xjournal_volume
43pub_type
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