Abstract:
:Interstitial fluid flow has been shown to affect the organization and behavior of cells in 3D environments in vivo and in vitro, yet the forces driving such responses are not clear. Due to the complex architecture of the extracellular matrix (ECM) and the difficulty of measuring fluid flow near cells embedded in it, the levels of shear stress experienced by cells in this environment are typically estimated using bulk-averaged matrix parameters such as hydraulic permeability. While this is useful for estimating average stresses, it cannot yield insight into how local matrix fiber architecture-which is cell-controlled in the immediate pericellular environment-affects the local stresses imposed on the cell surface. To address this, we used computational fluid dynamics to study flow through an idealized mesh constructed of a cubic lattice of fibers simulating a typical in vitro collagen gel. We found that, in such high porosity matrices, the fibers strongly affect the flow fields near the cell, with peak shear stresses up to five times higher than those predicted by the Brinkman equation. We also found that minor remodeling of the fibers near the cell surface had major effects on the shear stress profile on the cell. These findings demonstrate the importance of fiber architecture to the fluid forces on a cell embedded in a 3D matrix, and also show how small modifications in the local ECM can lead to large changes in the mechanical environment of the cell.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Pedersen JA,Boschetti F,Swartz MAdoi
10.1016/j.jbiomech.2006.06.023subject
Has Abstractpub_date
2007-01-01 00:00:00pages
1484-92issue
7eissn
0021-9290issn
1873-2380pii
S0021-9290(06)00237-5journal_volume
40pub_type
杂志文章abstract::The aim of this work is to contribute to elucidating the mechanism underlying gas mixing in the human pulmonary airways. For this purpose, a particular attempt is made to analyse the fluid mechanical aspects of gaseous dispersion using bolus response methods. The experiments were performed on five normal subjects by i...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/0021-9290(85)90295-7
更新日期:1985-01-01 00:00:00
abstract::In this article, the tensile properties of gastric wall were investigated by using biomechanical test and theoretical analysis. The samples of porcine stomach strips from smaller and greater curvature of the stomach were cut in longitudinal and circumferential direction, respectively. The loading-unloading, stress rel...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2014.12.048
更新日期:2015-02-26 00:00:00
abstract::The importance of the aortic root compliance in the aortic valve performance has most frequently been ignored in computational valve modeling, although it has a significant contribution to the functionality of the valve. Aortic root aneurysm or (calcific) stiffening severely affects the aortic valve behavior and, cons...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/s0021-9290(02)00448-7
更新日期:2003-05-01 00:00:00
abstract::This paper presents a method for analyzing and comparing numerically Saphenous Vein Grafts (SVGs) following Coronary Artery Bypass Graft surgery (CABG). The method analyses the flow dynamics inside vein grafts with and without supporting using Venous External Scaffolding Technology (VEST). The numerical method uses pa...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2015.03.011
更新日期:2015-07-16 00:00:00
abstract::As plaque develops in arteries two types of remodeling can occur; positive and negative remodeling. Positive remodeling is an outward compensatory remodeling in which the arterial wall grows outward in an attempt to maintain a constant lumen diameter, while negative remodeling is defined as a local shrinkage of vessel...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2013.02.012
更新日期:2013-04-26 00:00:00
abstract::The structure and function of the renal artery ostium flow diverter on the caudal side of the renal branch point were previously reported; in this study, we further evaluate the diverter׳s possible functions. The protrusion of this structure into the abdominal aorta suggests that the diverter may preferentially direct...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2014.03.006
更新日期:2014-05-07 00:00:00
abstract::Intravascular stents are small tube-like structures expanded into stenotic arteries to restore blood flow perfusion to the downstream tissues. The stent is mounted on a balloon catheter and delivered to the site of blockage. When the balloon is inflated, the stent expands and is pressed against the inner wall of the c...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/s0021-9290(02)00033-7
更新日期:2002-06-01 00:00:00
abstract::Understanding proximal femur fracture may yield new targets for fracture prevention screening and treatment. The goal of this study was to characterize force-displacement and failure behaviours in the proximal femur between displacement control and impact loading fall simulations. Twenty-one human proximal femurs were...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2014.06.040
更新日期:2014-11-28 00:00:00
abstract::The pleural surfaces of the chest wall and lung slide against each other, lubricated by pleural fluid. During sliding motion of soft tissues, shear induced hydrodynamic pressure deforms the surfaces, promoting uniformity of the fluid layer thickness, thereby reducing friction. To assess pleural deformability at length...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2011.07.008
更新日期:2011-09-23 00:00:00
abstract::A new strain energy function for the hyperelastic modelling of ligaments and tendons based on the geometrical arrangement of their fibrils is derived. The distribution of the crimp angles of the fibrils is used to determine the stress-strain response of a single fascicle, and this stress-strain response is used to det...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2014.11.031
更新日期:2015-01-21 00:00:00
abstract::The ability to quantitatively measure stability is essential to ensuring the safety of locomoting systems. While the response to perturbation directly reflects the stability of a motion, this experimental method puts human subjects at risk. Unfortunately, existing indirect methods for estimating stability from unpertu...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2018.02.022
更新日期:2018-04-27 00:00:00
abstract::The use of swim fins has become popular in various water sport activities. While numerous models of swim fin with various innovative shapes have been subjectively designed, the exact influence of the fin characteristics on swimming performance is still much debated, and remains difficult to quantify. To date, the most...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2010.03.031
更新日期:2010-07-20 00:00:00
abstract::The effect of dissipative mechanical loads on spastic gait has been studied, to evaluate the feasibility of using mechanically damped orthoses to effect functional improvements in the gait of spastic patients. This concept is based on a hypothesis citing uninhibited, velocity-dependent stretch reflexes as a possible c...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/0021-9290(85)90278-7
更新日期:1985-01-01 00:00:00
abstract::Increasing diversity in the STEM (Science, Technology, Engineering, and Math) fields has become imperative to ensure equitable access to economic opportunity and to provide the technologically adept workforce of the future. The present STEM pipeline preferentially engages youth who are, not only aware of and intereste...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2019.109511
更新日期:2020-01-23 00:00:00
abstract::We developed a computational model of lung parenchyma, which is comprised of individual alveolar chamber models. Each alveolus is modeled by a truncated octahedron. Considering the force balance between the elastin and collagen fibers laying on the alveolar membrane and the pressures acting on the membrane, we compute...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2012.11.031
更新日期:2013-01-18 00:00:00
abstract::Integration of objective biomechanical measures of foot function into the design process for insoles has been shown to provide enhanced plantar tissue protection for individuals at-risk of plantar ulceration. The use of virtual simulations utilizing numerical modeling techniques offers a potential approach to further ...
journal_title:Journal of biomechanics
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jbiomech.2017.06.028
更新日期:2017-07-26 00:00:00
abstract::The purpose of this study was to investigate the effect of thickness, cross-sectional area and stiffness of intrinsic foot muscles on performance in single-leg stance balance tasks in healthy sedentary young females. This study included a total of 40 healthy sedentary young females between the ages of 19 and 35 years....
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2019.109530
更新日期:2020-01-23 00:00:00
abstract::The finite element method described in this study provides an easy method to simulate the kinetics of multibody mechanisms. It is used in order to develop a musculoskeletal model of the shoulder mechanism. Each relevant morphological structure has been represented by an appropriate element. For the shoulder mechanism ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/0021-9290(94)90065-5
更新日期:1994-05-01 00:00:00
abstract::The purpose of this study was to determine whether the same estimates of individual muscle and L4/L5 lumbar joint compressive forces result from an optimization (OPT) compared to an electromyography (EMG) assisted approach for solving the inderminate moment equilibrium equations in the same anatomical model. Four male...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/0021-9290(94)00065-c
更新日期:1995-03-01 00:00:00
abstract::We evaluated whether the use of cartilage thickness measurement would improve the ability of the arthroscopic indentation technique to estimate the intrinsic stiffness of articular cartilage. First, cartilage thickness and ultrasound reflection from the surface of bovine humeral head were registered in situ using a hi...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/s0021-9290(00)00189-5
更新日期:2001-02-01 00:00:00
abstract::The physical environment surrounding an animal has a significant impact on its behavior. The nematode Caenorhabditis elegans (C. elegans) has proved to be an excellent choice for understanding the adaptability of organisms crawling on soft surfaces. In this work, we investigate the modulation of C. elegans' behavioral...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2017.02.015
更新日期:2017-04-11 00:00:00
abstract:OBJECTIVE:Ex vivo studies have suggested that cartilage contact areas and pressure are of high clinical relevance in the etiology of osteoarthritis in patients with patellar subluxation. The aims of this study were therefore to validate in vivo measurements of contact areas with 3D open magnetic resonance imaging (MRI)...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2004.09.008
更新日期:2005-10-01 00:00:00
abstract::Aim was to develop an in vivo technique which allows determination of femoro-tibial and of femoro-patellar 3D-kinematics in TKA simultaneously. The knees of 20 healthy volunteers and of eight patients with TKA (PCR, rotating platform) were investigated. Kinematics analysis was performed in an open MR-system at differe...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2007.03.020
更新日期:2007-01-01 00:00:00
abstract::Although shear wave elastography (SWE) has been used to indirectly measure passive tension in muscle tissues, it is unknown whether SWE can adequately evaluate passive tension in capsule tissues. This study investigated the relationship between the shear modulus and passive tension in the posterior shoulder capsule us...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2019.109498
更新日期:2020-01-23 00:00:00
abstract::In human walking, the center of mass motion is similar to an inverted pendulum. Viewing double support as a transition from one inverted pendulum to the next, we hypothesized that the leading leg performs negative work to redirect the center of mass velocity, while simultaneously, the trailing leg performs positive wo...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/s0021-9290(01)00169-5
更新日期:2002-01-01 00:00:00
abstract::Nanoindentation has been widely used as a means to measure the micro-mechanical properties of bone and to predict the macroscopic properties. The role of indent depth and indenter tip geometry in measuring the hierarchical properties of bone tissue was explored experimentally using a range of spherical indenter tips o...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2010.10.008
更新日期:2011-01-11 00:00:00
abstract::In this paper, we measured the maximum isometric force at the hand in eight directions in the horizontal plane and at five positions in the workplace. These endpoint forces were the result of shoulder horizontal adduction/abduction and elbow flexion/extension torques. We found that the normalized maximum forces of all...
journal_title:Journal of biomechanics
pub_type: 临床试验,杂志文章
doi:10.1016/j.jbiomech.2005.01.004
更新日期:2006-01-01 00:00:00
abstract::Stem-cement and cement-bone interfacial failures as well as cement fractures have been noted in cemented total hip arthroplasty (THA) as the cause of aseptic loosening. Attempts to reduce the risk of femoral component loosening include improving the stem-cement interface by various coatings, using a textured or porous...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2012.12.010
更新日期:2013-03-15 00:00:00
abstract::A design is presented for a bicycle pedal dynamometer that measures both normal and tangential forces (i.e. driving forces). Mechanical decoupling is used to reduce the cross-sensitivity of the dynamometer to loads doing no work to propel the bicycle. This obviates the need to measure all six loads for accurate data r...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/0021-9290(88)90144-3
更新日期:1988-01-01 00:00:00
abstract::In order to support the decisions of medical experts and to develop better stent designs, the availability of a simulation tool for virtual stenting would be extremely useful. An innovative virtual stenting technique is described in this work, which is directly applicable for complex patient-specific geometries. A bas...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2012.08.047
更新日期:2013-01-04 00:00:00