Abstract:
:The purpose of the present study was to investigate the effects of mechanical strain, anisotropy, and tissue region on electrical conductivity and ion diffusivity in meniscus fibrocartilage. A one-dimensional, 4-wire conductivity experiment was employed to measure the electrical conductivity in porcine meniscus tissues from two tissue regions (horn and central), for two tissue orientations (axial and circumferential), and for three levels of compressive strain (0%, 10%, and 20%). Conductivity values were then used to estimate the relative ion diffusivity in meniscus. The water volume fraction of tissue specimens was determined using a buoyancy method. A total of 135 meniscus samples were measured; electrical conductivity values ranged from 2.47mS/cm to 4.84mS/cm, while relative ion diffusivity was in the range of 0.235 to 0.409. Results show that electrical conductivity and ion diffusion are significantly anisotropic (p<0.001), both being higher in the circumferential direction than in the axial direction. Additionally, the findings show that compression significantly affects the electrical conductivity with decreasing conductivity levels corresponding to increased compressive strain (p<0.001). Furthermore, there was no statistically significant effect of tissue region when comparing axial conductivity in the central and horn regions of the tissue (p=0.999). There was a positive correlation between tissue water volume fraction and both electrical conductivity and relative ion diffusivity for all groups investigated. This study provides important insight into the electromechanical and transport properties in meniscus fibrocartilage, which is essential in developing new strategies to treat and/or prevent tissue degeneration.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Kleinhans KL,McMahan JB,Jackson ARdoi
10.1016/j.jbiomech.2016.06.011subject
Has Abstractpub_date
2016-09-06 00:00:00pages
3041-3046issue
13eissn
0021-9290issn
1873-2380pii
S0021-9290(16)30673-Xjournal_volume
49pub_type
杂志文章abstract::Increased knee flexion during stance is a common gait deviation in the child with cerebral palsy (CP), with distal hamstring lengthening surgeries being an accepted course of treatment. Post-operatively, improvements in gait kinematics have been reported, however little change is noted in the patterns of muscle activi...
journal_title:Journal of biomechanics
pub_type: 临床试验,杂志文章
doi:10.1016/j.jbiomech.2007.01.001
更新日期:2007-01-01 00:00:00
abstract::Fixation failure of glenoid components is the main cause of unsuccessful total shoulder arthroplasties. The characteristics of these failures are still not well understood, hence, attempts at improving the implant fixation are somewhat blind and the failure rate remains high. This lack of understanding is largely due ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2009.10.019
更新日期:2010-03-03 00:00:00
abstract::The principal motivation for the present work was the study of the kinetics of anaerobic metabolism. A new mathematical model of the bioenergetics of sprinting, incorporating a three-equation representation of anaerobic metabolism, is developed. Results computed using the model are compared with measured data from the...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/s0021-9290(00)00035-x
更新日期:2000-08-01 00:00:00
abstract::The problem of peristaltic transport of blood in a uniform and non-uniform tube has been investigated, under zero Reynolds number and long wavelength approximation. Blood is represented by a two-layered fluid model consisting of a central layer of suspension of all erythrocytes, etc., assumed to be a Casson fluid, and...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/0021-9290(84)90140-4
更新日期:1984-01-01 00:00:00
abstract::Upper extremity musculoskeletal disorders represent an important health issue across all industry sectors; as such, the need exists to develop models of the hand that provide comprehensive biomechanics during occupational tasks. Previous optical motion capture studies used a single marker on the dorsal aspect of finge...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2011.04.003
更新日期:2011-06-03 00:00:00
abstract::A new software tool to assign the material properties of bone to an ABAQUS finite element mesh was created and compared with Bonemat, a similar tool originally designed to work with Ansys finite element models. Our software tool (py_bonemat_abaqus) was written in Python, which is the chosen scripting language for ABAQ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2016.07.037
更新日期:2016-09-06 00:00:00
abstract::Human cortical bone fracture toughness depends on the anatomical locations under quasi-static loading. Recent results also showed that under fall-like loading, cortical bone fracture toughness is similar at different anatomical locations in the same donor. While cortical bone toughening mechanisms are known to be depe...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2019.01.008
更新日期:2019-03-06 00:00:00
abstract::Understanding microstructural changes that occur in skin subjected to repetitive mechanical stress is crucial towards the development of therapies to enhance skin adaptation and load tolerance in patients at risk of skin breakdown (e.g. prosthesis users, wheelchair users). To determine if collagen fibril diameter, col...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/s0021-9290(01)00145-2
更新日期:2001-12-01 00:00:00
abstract::The finite element (FE) method based on high-resolution peripheral quantitative computed tomography (HR-pQCT) use a variety of tissue constitutive properties and boundary conditions at different laboratories making comparison of mechanical properties difficult. Furthermore, the advent of a second-generation HR-pQCT po...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2018.08.030
更新日期:2018-10-26 00:00:00
abstract::Motion capture systems currently used in biomechanical analysis introduce systematic measurement errors that appear in the form of noise in recorded displacement signals. The noise is unacceptably amplified when differentiating displacements to obtain velocities and accelerations. To avoid this phenomenon, it is neces...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2004.05.031
更新日期:2005-05-01 00:00:00
abstract::Friction between the prosthetic head and acetabular cup increases the temperature in hip implants during activities like walking. A hip endoprosthesis was instrumented with sensors to measure the joint contact forces and the temperature distribution along the entire length of the titanium implant. Sensors and two indu...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/s0021-9290(99)00110-4
更新日期:1999-10-01 00:00:00
abstract::Soft tissue artefact (STA) and marker placement variability are sources of error when measuring the intrinsic kinematics of the foot. This study aims to demonstrate a non-invasive, combined ultrasound and motion capture (US/MC) technique to directly measure foot skeletal motion. The novel approach is compared to a sta...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2013.12.014
更新日期:2014-03-21 00:00:00
abstract::The primary aim of this work is to investigate the potential of nonlinear ultrasound for microdamage detection in human bone. Microdamage evaluation in human bone is of great importance, because it is considered a significant parameter for characterizing fracture risk. Experiments employing nonlinear acoustic vibro-mo...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2008.12.018
更新日期:2009-03-26 00:00:00
abstract::A numerical-experimental approach has been developed to characterize heel-pad deformation at the material level. Left and right heels of 20 diabetic subjects and 20 nondiabetic subjects matched for age, gender and body mass index were indented using force-controlled ultrasound. Initial tissue thickness and deformation...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2005.03.007
更新日期:2006-01-01 00:00:00
abstract::Computational models have recently been developed to replicate experimental conditions present in the Stanmore knee wear simulator. These finite element (FE) models, which provide a virtual platform to evaluate total knee replacement (TKR) mechanics, were validated through comparisons with experimental data for a spec...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2005.07.029
更新日期:2006-01-01 00:00:00
abstract::Knee kinetic asymmetries are present during jump-landings in athletes returning to sport following anterior cruciate ligament (ACL) reconstruction, and are associated with an increased risk for sustaining a second ACL injury. The loadsol® is a wireless load sensing insole that can be used in non-laboratory settings. T...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2019.07.037
更新日期:2019-10-11 00:00:00
abstract::Lymphatic valves facilitate the lymphatic system's role in maintaining fluid homeostasis. Malformed valves are found in several forms of primary lymphœdema, resulting in incurable swelling of the tissues and immune dysfunction. Their experimental study is complicated by their small size and operation in low pressure a...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2017.09.040
更新日期:2017-11-07 00:00:00
abstract::Despite recent attention in the literature, anterior cruciate ligament (ACL) injury mechanisms are controversial and incidence rates remain high. One explanation is limited data on in vivo ACL strain during high-risk, dynamic movements. The objective of this study was to quantify ACL strain during jump landing. Marker...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2010.10.028
更新日期:2011-02-03 00:00:00
abstract::This study sought to gain insights into the steps leading to remineralization and mechanical recovery of hydrated dentin. Mechanical recovery in water was hypothesized to result from effective mineral matrix binding and to occur from the innermost regions outwards due to an increase in the number of nucleation sites. ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2010.09.005
更新日期:2011-01-04 00:00:00
abstract::We previously reported an ultrasound method for measuring the depth-dependent equilibrium mechanical properties of articular cartilage using quasi-static compression. The objective of this paper was to introduce our recent development for nondestructively measuring the transient depth-dependent strains of full-thickne...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2004.08.020
更新日期:2005-09-01 00:00:00
abstract::As a hybrid between a hypodermic needle and transdermal patch, we have used microfabrication technology to make arrays of micron-scale needles that transport drugs and other compounds across the skin without causing pain. However, not all microneedle geometries are able to insert into skin at reasonable forces and wit...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2003.12.010
更新日期:2004-08-01 00:00:00
abstract::The purpose of this study was to determine whether the same estimates of individual muscle and L4/L5 lumbar joint compressive forces result from an optimization (OPT) compared to an electromyography (EMG) assisted approach for solving the inderminate moment equilibrium equations in the same anatomical model. Four male...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/0021-9290(94)00065-c
更新日期:1995-03-01 00:00:00
abstract::A truss structure was recently introduced as an interbody fusion cage. As a truss system, some of the connected elements may be in a state of compression and others in tension. This study aimed to quantify both the mean and variance of strut strains in such an implant when loaded in a simulated fusion condition with v...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2016.10.051
更新日期:2016-12-08 00:00:00
abstract::During normal daily activity, muscle motor units (MUs) develop unfused tetanic contractions evoked by trains of motoneuronal firings at variable interpulse intervals (IPIs). The mechanical responses of a MU to successive impulses are not identical. The aim of this study was to develop a mathematical approach for the p...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2010.01.034
更新日期:2010-05-28 00:00:00
abstract::A biomechanical model of the forearm, consisting of 61 muscle-tendon systems or tendons and 8 sections, is presented. The model can be used to calculate the muscle forces when resultant of the external forces and the motion is known. Calculations are based on constraints of muscle forces, joint forces, contact forces,...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/s0021-9290(01)00009-4
更新日期:2001-05-01 00:00:00
abstract::The negative charges on proteoglycans significantly affect the mechanical behaviors of articular cartilage. Mixture theories, such as the triphasic theory, can describe quantitatively how this charged nature contributes to the mechano-electrochemical behaviors of such tissue. However, the mathematical complexity of th...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2009.10.026
更新日期:2010-03-03 00:00:00
abstract::Hammocks and cradles have long been appreciated, but in a very limited way. Aside from being emotionally soothing the devices affect the skin and all deep body components. While structurally simple they are functionally quite sophisticated and could very well affect the pattern of health care across the board--acute, ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/0021-9290(84)90089-7
更新日期:1984-01-01 00:00:00
abstract::Currently available musculoskeletal inverse-dynamics thoracolumbar spine models are entirely based on data from adults and might therefore not be applicable for simulations in children and adolescents. In addition, these models lack lower extremities, which are required for comprehensive evaluations of functional acti...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2019.07.049
更新日期:2020-03-26 00:00:00
abstract::In this study, the dynamic compressive properties in five different regions of the porcine temporomandibular joint (TMJ) disc are investigated over a wide range of loading frequencies. The aim was, thus far, to evaluate the regional difference and the frequency-related effect of the applied load on these properties. E...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2012.11.035
更新日期:2013-02-22 00:00:00
abstract::Mechnotransduction, the phenomenon by which cells respond to applied force, is necessary for normal cell processes and is implicated in the pathology of several diseases including atherosclerosis. The exact mechanisms which govern how forces can affect gene expression have not been determined, but putative direct forc...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2008.08.024
更新日期:2008-11-14 00:00:00