Abstract：
:This paper proposes a mathematical model for vessel recruitment in the microvascular coronary network. The model is based on microvascular network units (MVNUs), where we define a MVNU as a portion of the microvascular network comprising seven generations of identical, parallel-arranged vessels (upstream arteries, large and small arterioles, capillaries, small and large venules, and downstream veins). The model implements a new mechanism to describe the variation in the number of MVNU in response to sudden variations of the local input pressure. In particular, it describes a recruitment mechanism dependent on distal pressure which operates in the coronary microcirculatory network even in maximally dilated conditions. We apply the model to interpret data from 29 patients who underwent revascularization by percutaneous coronary intervention (PCI). Treated vessels were the left anterior descending coronary artery, the left circumflex and the right coronary artery in 26, 2 and 1 patients, respectively. Following intracoronary adenosine administration, distal coronary pressure and blood flow were 48 ± 18 mmHg and 45 ± 30 ml/min before PCI, respectively, and significantly increased afterwards to 80 ± 17 mmHg and 68 ± 32 ml/min (p<0.001). The model predicts an increase in MVNU number in patients with preserved wall motion in the myocardial region which underwent PCI. On the contrary, a decrease in MVNU number is predicted by the model in patients with regional dysfunction and implies a relatively lower response of maximal flow to revascularization.
journal_name
Microvasc Resjournal_title
Microvascular researchauthors
Saracco A,Bauckneht M,Verna E,Ghiringhelli S,Repetto R,Sambuceti G,Provasoli S,Storace Mdoi
10.1016/j.mvr.2015.11.006subject
Has Abstractpub_date
2016-03-01 00:00:00pages
38-45eissn
0026-2862issn
1095-9319pii
S0026-2862(15)30037-6journal_volume
104pub_type
杂志文章abstract：:Cardiovascular diseases, among all diseases, are taking the most victims worldwide. Coronary artery occlusion, takes responsibility of about 30% of the yearly global deaths in the world (Heart Disease and Stroke Statistics 2017 At-a-Glance, 2017), raising the need for viable substitutes for cardiovascular tissues. Dep...
journal_title：Microvascular research
pub_type： 杂志文章,评审
doi：10.1016/j.mvr.2020.104027
更新日期：2020-09-01 00:00:00
abstract：:The purpose of this study was to elucidate the mechanism by which bradykinin (BK) enhances prostacyclin (PGI(2)) production in human umbilical vein endothelial cells (HUVEC). BK-induced enhancement of PGI(2) synthesis was observed in a dose- and time-dependent manner, and it also increased [Ca(2+)](i) followed by enha...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1999.2163
更新日期：1999-09-01 00:00:00
abstract：:Non-freezing cold injury (NFCI) is a prevalent, but largely undiagnosed and poorly understood syndrome afflicting many who, as part of their work or leisure, expose their extremities to cold temperatures. The long term sequelae of NFCI are hyperhidrosis, cold-sensitivity and pain; these can last a lifetime. We tested ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2013.11.002
更新日期：2014-01-01 00:00:00
abstract：:Microvascular blood flow is commonly calculated from a "centerline" velocity derived from the dual-slit method. This is done by relating the computed centerline velocity to an average velocity through an empirically derived conversion factor. To determine the physical basis of the conversion factor, we utilized a Four...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(89)90046-0
更新日期：1989-05-01 00:00:00
abstract：:Arterioles in various vascular beds have been often observed to have nonuniform diameters along the vessel axis. The effect of nonuniformity of arteriolar diameter on vascular resistance was investigated using a theoretical model of blood flow in arterioles. Viscous flow of a Newtonian fluid in tubes with periodically...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(89)90023-x
更新日期：1989-09-01 00:00:00
abstract：:We observed the retinal capillary pericytes of the rat in situ. Whole retinae were mounted, immediately post vivo, in a special tissue chamber for electronic light microscopy at high magnifications. Under electronic light microscopy the pericytes could be clearly distinguished from the endothelial cells. In addition, ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1998.2086
更新日期：1998-07-01 00:00:00
abstract：:In the present study, human myometrial microvascular endothelial cells (HMMEC) were cocultured with human vascular smooth muscle cells (VSMC) labeled with fluorescent dyes to examine their morphological interaction using confocal laser fluorescent microscopy. HMMEC and VSMC labeled with fluorescent green and red dyes,...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2005.04.008
更新日期：2005-07-01 00:00:00
abstract：:Changes in blood vessel diameter can be measured manually, but this is time-consuming and often impractical. For automatic measurement commercial solutions are available, but the proprietary algorithms and their potential shortcomings are not known to the user. We present an approach with a CCD camera for image acquis...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2010.04.004
更新日期：2010-09-01 00:00:00
abstract：:H2O2 mediates autocrine and paracrine signaling in the vasculature and can propagate endothelial dysfunction. However, it is not clear how endothelial cells withstand H2O2 exposure and promote H2O2-induced vascular remodeling. To understand the innate ability of endothelial cells for sustaining excess H2O2 exposure, w...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2015.09.003
更新日期：2016-01-01 00:00:00
abstract：:The microfibrils of anchoring filaments, a typical ultrastructural feature of initial lymphatic vessels, consist mainly of fibrillin and are similar to the microfibrils of elastic fibers. As we previously demonstrated, they radiate from focal adhesions of lymphatic endothelium to the perivascular elastic network. Alth...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.2002.2397
更新日期：2002-07-01 00:00:00
abstract：:To investigate the effect of vascular endothelial growth factor (VEGF) on solute permeability of mammalian microvessels, we measured the apparent permeability (P) of various-sized solutes on the postcapillary venules of rat mesentery in vivo. Exposure to 1 nM VEGF transiently increased P from a mean of 1.4 (+/-0.11 SE...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2004.03.004
更新日期：2004-07-01 00:00:00
abstract：:P120 catenin (p120ctn) belongs to the family of Armadillo repeat-containing proteins, which are believed to have dual functions of cell-cell adhesion and transcriptional regulation. In vascular endothelium, p120ctn is mostly recognized for its cell-cell adhesion function through its ability to regulate VE-cadherin. Th...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2010.04.001
更新日期：2010-09-01 00:00:00
abstract：:Overexpression of EGFR plays a key-role in head and neck squamous cell carcinoma (HNSCC) and justifies the extensive use of cetuximab, a monoclonal anti-EGFR antibody, as well as EGFR-tyrosine kinase inhibitors (EGFR-TKI), which have been reported to inhibit tumor cell growth and the secretion of pro-angiogenic factor...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2011.07.008
更新日期：2012-03-01 00:00:00
abstract：:Polymorphonuclear leukocytes are thought to play a pivotal role in the generation of ischemia-reperfusion-induced mucosal injury; however, their behavior in the intestinal microvasculature following this injury has not been directly examined. In this study intravital microscopy was used to investigate the dynamics of ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1994.1028
更新日期：1994-05-01 00:00:00
abstract：:The purpose of the present study was to investigate the nervous control of gingival blood flow in cats. Gingival blood flow was measured by laser Doppler flowmeter in 75 cats during electrical stimulation and cutting or ligation of the inferior alveolar nerve and cervical sympathetic nerve without sympathectomy or pre...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(90)90061-u
更新日期：1990-01-01 00:00:00
abstract：:Pigment epithelium-derived factor (PEDF) is a potent inhibitor of angiogenesis in the mammalian eye, suggesting that loss of PEDF is implicated in the pathogenesis of proliferative diabetic retinopathy. However, a role for PEDF in early diabetic retinopathy remains to be elucidated. Since oxidative stress is thought t...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2004.11.001
更新日期：2005-01-01 00:00:00
abstract：:Endothelial dysfunction is common in patients with chronic kidney disease (CKD) and contributes significantly to the high long-term cardiovascular morbidity and mortality. The short-term cardiovascular effects of recombinant human growth hormone (rhGH) in CKD patients (stages III-V) and healthy controls (n=15 each) we...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2009.05.006
更新日期：2009-09-01 00:00:00
abstract：BACKGROUND:The burden of type 1 diabetes (T1D) is growing worldwide, stressing the requirement to limit the threat of its long-term complications. In this regard, the development of methods for the early diagnosis and non-invasive monitoring of vascular abnormalities is widely recognized as one of the greatest prioriti...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2019.04.002
更新日期：2019-07-01 00:00:00
abstract：:Techniques of intravital microscopy were used to assess the effect of the nonsteroidal anti-inflammatory drugs (NSAIDs), indomethacin and ibuprofen, on the microcirculation. Hemodynamics in venules of the rat mesentery were studied in terms of vessel diameter, red blood cell velocity, and leukocyte-endothelium interac...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1993.1016
更新日期：1993-03-01 00:00:00
abstract：:Developing tissue engineering approaches to generate functional vascular networks is important for improving treatments of peripheral and cardiovascular disease. Endothelial colony forming cells (ECFCs) are an endothelial progenitor cell (EPC) population defined by high proliferative potential and an ability to vascul...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2010.03.001
更新日期：2010-07-01 00:00:00
abstract：:Particle tracking velocimetry provides a Lagrangian description of flow properties in the microcirculation. To determine the utility of fluorescent nanoparticles to provide Lagrangian coordinates, we tracked these particles both in vitro and in vivo. The particles had a neutral charge and fluorescence intensity greate...
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pub_type： 杂志文章
doi：10.1016/j.mvr.2006.04.006
更新日期：2006-07-01 00:00:00
abstract：:Despite intensive study in the area of angiogenesis, relatively little is known about normal angiogenesis in adult animals. Preliminary studies using the Griffonia simplicifolia I (GSI) lectin as a microvascular marker indicated that capillary sprouting occurs in the clear "windows" of normal intact adult rat mesenter...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1994.1029
更新日期：1994-05-01 00:00:00
abstract：:Most forms of tissue healing depend critically on revascularisation. In soft tissues and in vitro, mechanical stimuli have been shown to promote vessel-forming activity. However, in bone defects, increased interfragmentary motion impairs vascular regeneration. Because these effects seem contradictory, we aimed to dete...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2009.08.002
更新日期：2009-12-01 00:00:00
abstract：:Diabetic retinopathy (DR) is a disease that causes blindness due to vascular leakage or abnormal angiogenesis. Hepatocyte growth factor (HGF) is increased in the serum or vitreous fluid in proliferative diabetic retinopathy (PDR) patients, although the effect of HGF on the blood vessels remains unclear. This study foc...
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doi：10.1016/j.mvr.2020.104103
更新日期：2021-01-01 00:00:00
abstract：:Shear stress causes release of nitric oxide (NO) from microvascular endothelial cells in vivo and stimulates their growth in vitro. After chronic electrical stimulation of lower hind limb skeletal muscles in the rat, measurements of capillary diameters and red blood cell velocity indicated that shear stress is increas...
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pub_type： 杂志文章
doi：10.1006/mvre.1999.2193
更新日期：2000-01-01 00:00:00
abstract：:Vessel size index (R(v), μm) has been proposed as a quantitative magnetic resonance imaging (MRI) derived imaging biomarker in oncology, for the non-invasive assessment of tumour blood vessel architecture and vascular targeted therapies. Appropriate pre-clinical evaluation of R(v) in animal tumour models will improve ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2012.08.001
更新日期：2012-11-01 00:00:00
abstract：:We have used ruthenium red, a cationic dye, to detect at the electron microscopic level the presence of anionic sites in various murine basement membranes, with particular emphasis on those of the microvasculature. We have observed anionic sites in all continuous and fenestrated capillaries examined. Terminal lymphati...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(83)90018-3
更新日期：1983-05-01 00:00:00
abstract：:Hypoxia-inducible factor-1 (HIF-1) orchestrates angiogenesis under hypoxic conditions mainly due to increased expression of such target genes as vascular endothelial growth factor (VEGF). Na+/H+exchanger-1 (NHE1), a potential HIF target gene product, plays a pivotal role in proliferation, survival, migration, adhesion...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2010.12.004
更新日期：2011-03-01 00:00:00
abstract：:A well developed capillary bed is essential for proper function of skeletal muscles. We present for the first time a triple immunofluorescent method suitable for staining capillaries and muscle fibre outlines in thick sections of human skeletal muscle, applying antibodies against collagen IV (in red) and F8 (in green)...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2010.11.012
更新日期：2011-03-01 00:00:00
abstract：:Capillary diameters in sartorius muscle of frogs were measured in vivo by means of a new computer video method, based on the passage of red blood cells (RBCs) through the capillary (C. Ellis, R. Sanfranyos, and A. Groom (1983), Microvasc. Res. 26, 139-150). The distribution of capillary diameters from 21 frogs was rep...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(83)90066-3
更新日期：1983-09-01 00:00:00
