Abstract：
:A new gamma-aminobutyric acid derivative, N-phthaloyl GABA (P-GABA), was synthesised and its anticonvulsant activity was tested and compared with sodium valproate for efficacy against experimentally induced convulsions in mice. At a dose of 80 mg/kg, P-GABA rendered more protection than sodium valproate. ED50 of P-GABA and sodium valproate against bicuculline-induced convulsion was 96 and 301 mg/kg respectively in mice.
journal_name
Indian J Exp Bioljournal_title
Indian journal of experimental biologyauthors
Bhowmick S,Pal M,Pal SPsubject
Has Abstractpub_date
1989-09-01 00:00:00pages
805-8issue
9eissn
0019-5189issn
0975-1009journal_volume
27pub_type
杂志文章abstract：:Enzyme cyclooxygenase (COX) is reported to play a significant role in neurodegeneration and may play a significant role in the pathogenesis of epilepsy. Bicuculline (4 mg/kg; ip), picrotoxin (8 mg/kg; ip) and electroshock (60 mA for 0.2 sec) significantly induced convulsions in male Laka mice. COX-inhibitors viz. nime...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2006-04-01 00:00:00
abstract：:Ten oleaginous yeasts were isolated from sources like fruits, flowers, curd whey and soil samples. Lipid production varied from 24 to 71.2% of dry weight of cell biomass. Strain Y-1, which was isolated from curd whey, produced the highest amount of lipid. It was identified belonging to the genus Candida. The optimal c...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1997-03-01 00:00:00
abstract：:Rats pre-administered with alpha-tocopherol (10 mgs/day) for 7 days afforded a significant protection at the tissue level against the lowering of superoxide dismutase and glutathione peroxidase, especially the selenium-dependent glutathione peroxidase. The protective action of alpha-tocopherol in the diethyldithiocarb...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2007-05-01 00:00:00
abstract：:Pseudomonas aeruginosa MCCB 123 was grown in a synthetic medium for beta-1,3 glucanase production. From the culture filtrate, beta-1,3 glucanase was purified with a molecular mass of 45 kDa. The enzyme was a metallozyme as its beta-1,3 glucanase activity got inhibited by the metal chelator EDTA. Optimum pH and tempera...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
abstract：:Four plants having known medicinal properties were screened for inhibition of goatpox virus (GTPV) replication in vitro. Of the 4 plants, extract of Acacia arabica (Babul) and Eugenia jambolana (Jamun) leaves had inhibition (%) 99.70 and 99.92 at their maximum non toxic concentrations, 99.93 +/- 0.38 and 1999.73 +/- 0...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2008-02-01 00:00:00
abstract：:Hydantoin derivatives, including phenytoin (5,5-diphenylhydantoin), have recently gained attention as they possess a variety of important biochemical and pharmacological properties. Nevertheless, available information on anticancer activity of hydantoin derivatives is still scarce. Here, we evaluated possible antileuk...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2016-09-01 00:00:00
abstract：:There was a significant increase in fucose (52%), total hexoses (16%) and hexosamine (56%) except sialic acid, which was reduced (77%) in the microvillus membrane of infants born to rat mothers made diabetic by injecting alloxan on day 3 of gestation. Expressed on the protein basis there were a significant increase in...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：:Dual role of TGF-beta signaling in breast tumorigenesis as an inhibitor in early stages and promoter in advanced stages has been well established and known as TGF-beta switch. However, the biological mechanisms needs to be explored. Aim of the present study was to look for the usefulness of TGF-beta as a predictive ma...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2011-11-01 00:00:00
abstract：:Various storage treatments on human blood samples have been described with respect to DNA yield, quality and fingerprinting. Blood samples were stored at room temperature, 4 degrees C, -20 degrees C and -70 degrees C for different duration varying from 1, 2, 4 and 8 weeks with or without anticoagulant/preservative (ED...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1996-04-01 00:00:00
abstract：:Understanding the biochemical and molecular basis of drought mechanism in rice is important as drought is one of the major causes affecting rice crop adversely. A 1017 bp gene sequence encoding AP2/ERF family TF was isolated from Oryza sativa sp. Indica cv N22 encoding a protein of 338 amino acid residues, with a mole...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2016-01-01 00:00:00
abstract：:Tuberculin skin test (TST), an age old method is based on measuring delayed-type hypersensitivity (DTH) response to purified protein derivative (PPD). However, inspite of simplicity, ease and cost effectiveness, the usefulness of PPD test is limited due to its inability to distinguish among a protective immune respons...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2010-02-01 00:00:00
abstract：:Pseudomonas aeruginosa is one of the commonest pathogens among the pseudomonads. This organism can grow in minimal nutritional requirements. Because of the ability of pseudomonads to grow on paraffin is not commonly found among other human pathogens and the primary human pathogen being P. aeruginosa, we studied the ad...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2007-03-01 00:00:00
abstract：:Spirulina platensis treatment (400 mg kg(-1) for 25 days) effectively suppressed peripheral sensitization via modulation of glial activation and improved motor coordination and restoration of functional motor activity in collagen-induced arthritic rats. Spirulina treatment also resulted in an appreciable reduction of ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2011-10-01 00:00:00
abstract：:Primary regenerants (1190) of a tall traditional salt tolerant rice cultivar pokkali were produced through in vitro culture from mature seed derived calli of fourth subculture. Out of 35000 SC2 regenerants, 26 promising lines with superior agronomic traits were chosen initially for evaluation. SC3 and SC4 generations ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：:Shoots of apple rootstocks raised in vitro were transferred to various rooting media to study the effect of different factors on root initiation and development. Various concentrations of indole-3-butyric acid (IBA) initiated rooting but maximum rooting percentage was found with 2.0 and 2.5 mg l(-1) of IBA in M7 and w...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2007-09-01 00:00:00
abstract：:Crayfish exoskeleton (CE) samples are generally less invasive and easy to be collected. However, it is difficult to extract DNA from them. This study was intended to investigate CE as a DNA source and design an easy and efficient DNA extraction protocol for polymerase chain reactions. Specific primer pair (PPO-F, PPO-...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2011-12-01 00:00:00
abstract：:Thalidomide provided significant protection against tri nitro benzene sulfonic acid induced colitis. Combination therapy also reduced colonic inflammation and all the biochemical parameters (myeloperoxidase assay, malondialdehyde assay and tumor necrosis factor-alpha, estimation) were significant as compared to contro...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2011-09-01 00:00:00
abstract：:Effect of coumestans isolated form the leaves of W. calendulacea was evaluated in paracetamol induced liver damage. The increased serum enzyme levels (lactate dehydrogenase, alanine and aspartate transaminase and alkaline phophatase) by paracetamol induction were significantly lowered due to coumestans treatment. Resu...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2001-12-01 00:00:00
abstract：:The effect of the oral administration of megestrol acetate (MA; 17 alpha-acetoxy-6-dehydro-6-methylprogesterone) for 30 days at a dose of 40 mg/kg body weight/day on the genital organs and fertility of male rats was studied. MA had no effect on spermatogenesis or the fertility of the animals. However, the weights of...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1965-10-01 00:00:00
abstract：:Effect of uric acid on sodium oxalate-induced biochemical and histological changes were studied in rats. Rats injected with sodium oxalate (0.7 mg/100 g body wt, ip) show calcium deposits in the lumen of kidney tubules. Uric acid administration was found to potentiate calcium oxalate calculi formation. Lipid peroxide ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:Extract of the flower Malva viscus conzattii (M. conzattii) was administered at a dose of 25/50 mg/day/animal to 30 healthy adult male gerbils and 30 adult male house rats to determine its effect on fertility. After 25 days' treatment fin l body weight, and the weights of testes, epididymides, seminal vesicles, and a...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1977-07-01 00:00:00
abstract：:Ponderal, histological, and biochemical responses of the uterus, cervix, and vagina to the same dosage (1.5 mg/kg/day for 5 days) of cis- and transclomiphene were studied in ovariectomized rats in the presence and absence of estradiol-dipropionate (EDP). The results indicated that both isomers were estrogenic-cum-an...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1973-01-01 00:00:00
abstract：:N-Cyclohexyl-3-methoxyquinoxalin-2-carboxamide (QCM-13), a novel 5-HT3 antagonist identified from a series of compounds with higher pA2 (7.6) and good log P (2.91) value was screened in rodent models of depression such as forced swim test (FST), tail suspension test (TST), interaction studies with standard anti-depres...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2011-08-01 00:00:00
abstract：:Chickpea genomic library constructed earlier in phage lambda (EMBL-3) was screened for the presence of chitinase clone using tobacco chitinase cDNA as a probe. Positive clones obtained by primary screening of plaques (2 x 10(6)) were ascertained by secondary and tertiary screening. Presence of chitinase insert in the ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1996-06-01 00:00:00
abstract：:One day and 7 days old male white leghorn chicks were administered vitamin E prior to their exposure to sublethal dose (2.25 Gy) of gamma radiation from 60C source. The results show that vitamin E helps in faster recovery of damage in chick thymus caused by irradiation. ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1993-10-01 00:00:00
abstract：:O. mossambicus was exposed to sublethal concentrations of a textile mill effluent to study the hematological changes as a function of feeding/starvation, aeration/non-aeration and concentration. Increase in concentration produced a dose dependent increase in RBCs (0.87 x 10(6) to 1.63 x 10(6)/mm3), WBCs (0.070 x 10(6)...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1989-05-01 00:00:00
abstract：:Administration of bromocriptine (Bc), an ergot derivative having dopamine receptor agonist activity, to rats on day 1-5 of pregnancy prevented implantation of blastocysts and significantly suppressed uterine glucosamine 6-phosphate synthase activity. There was no effect on implantation or the enzyme activity when Bc w...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1993-04-01 00:00:00
abstract：:The Vero cell culture adapted buffalo pox virus was found to be completely attenuated at 40th passage for rabbits as well as buffaloes since it did not produce any thermal reaction or skin lesions. It induced high level of humoral and cell mediated immune response in rabbits as well as buffaloes. The antibody titres o...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1989-04-01 00:00:00
abstract：:Aqueous extract of leaves of M. oleifera was investigated and rationalised for its wound healing activity. The aqueous extract was studied at dose level of 300 mg/kg body weight using resutured incision; excision and dead space wound models in rats. Significant increase in wound closure rate, skin-breaking strength, g...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2006-11-01 00:00:00
abstract：:Oral administration of ethanol extract of N. sativa seeds (300 mg/kg body weight/day) to streptozotocin induced diabetic rats for 30 days significantly reduced the elevated levels of blood glucose, lipids, plasma insulin and improved altered levels of lipid peroxidation products (TBARS and hydroperoxides) and antioxid...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2006-09-01 00:00:00
