Abstract：
:Thalidomide provided significant protection against tri nitro benzene sulfonic acid induced colitis. Combination therapy also reduced colonic inflammation and all the biochemical parameters (myeloperoxidase assay, malondialdehyde assay and tumor necrosis factor-alpha, estimation) were significant as compared to control as well as thalidomide alone treated group. Combination therapy showed additive effect of thalidomide which restored lipid peroxidation as well as reduced myeloperoxidase and TNF-a towards the normal levels. Morphological and histological scores were significantly reduced in combination groups. In experimental model of colitis, oral administration of thalidomide (150 mg/kg) alone as well as its combination with sulfasalazine (360 mg/kg) significantly reduced the colonic inflammation. The results indicate the additive effect of thalidomide with sulfasalazine in rat colitis model which requires further confirmation in human studies.
journal_name
Indian J Exp Bioljournal_title
Indian journal of experimental biologyauthors
Prakash O,Medhi B,Saikia UN,Pandhi Psubject
Has Abstractpub_date
2011-09-01 00:00:00pages
672-8issue
9eissn
0019-5189issn
0975-1009journal_volume
49pub_type
杂志文章abstract：:A cyclic colony of P. papatasi was successfully established, using wild caught females. The major obstacle in the colonization was infestation of fungus, which was solved when bentonite, a dehydrant was mixed in the larval diet i.e., powdered and sterilized faecal pellets of rabbit. The average duration of development...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1992-10-01 00:00:00
abstract：:Effect of Swerchirin (1:8 dihydroxy 3:5 dimethoxy xanthone) isolated from hexane fraction of Swertia chirayita on the blood sugar level of healthy and streptozotocin treated rats was studied. Streptozotocin was administered in citrate buffer (pH-4.5) intravenously / 35 and 65 mg/kg body wt to Charles Foster strain alb...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1991-07-01 00:00:00
abstract：:The effect of the oral administration of megestrol acetate (MA; 17 alpha-acetoxy-6-dehydro-6-methylprogesterone) for 30 days at a dose of 40 mg/kg body weight/day on the genital organs and fertility of male rats was studied. MA had no effect on spermatogenesis or the fertility of the animals. However, the weights of...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1965-10-01 00:00:00
abstract：:Estrogenic and antiestrogenic properties of E-492, a nonsteroidal compound (3 methyl-4'-(beta-pyrrolidinoethoxy)-2,3-diphenyl propiophenone), were assessed on the basis of ponderal, histologic, and biochemical changes in the uterus, cervix, and vagina of ovariectomized adult rats. This compound was studied at its max...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1975-01-01 00:00:00
abstract：:In malaria, development of resistance towards artemisinin derivatives has urged the need for new drugs or new drug combinations to tackle the drug resistant malaria. We studied the fresh root extract of Vetiver zizanioides (Linn.) Nash (VET) with a CDRI-CIMAP antimalarial α/β arteether (ART) together for their antimal...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2016-05-01 00:00:00
abstract：:The in vitro percutaneous absorption of verapamil hydrochloride (VHCl) was investigated in order to assess its feasibility for transdermal development. The experiments were carried across mice and guinea pig skins using Keshary-Chien diffusion cell. The values of diffusion rate (J) and permeability coefficient (Kp) ac...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1996-05-01 00:00:00
abstract：:O. mossambicus was exposed to sublethal concentrations of a textile mill effluent to study the hematological changes as a function of feeding/starvation, aeration/non-aeration and concentration. Increase in concentration produced a dose dependent increase in RBCs (0.87 x 10(6) to 1.63 x 10(6)/mm3), WBCs (0.070 x 10(6)...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1989-05-01 00:00:00
abstract：:Prevalent notion about thyroid hormones is that thyroxine (T4) is a mere precursor and physiological effects of thyroid hormones are elicited by tri-iodothyronine (T3) after mono-deiodination of T4. Earlier studies on feather regeneration and molt done on spotted munia L. punctulata suggest that T4 (mono-deiodination ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2014-05-01 00:00:00
abstract：:Lead (100 ppm) was given in doubly deionised water for 30 days to one group of rats. The other groups received lead along with exogenous antioxidants like vitamin E (50 IU/kg), vitamin C (800 mg/kg) or Spirulina (1500 mg/kg) in food for a similar period. Levels of lipid peroxidation products such as malondialdehyde, c...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：:The present study evaluates effect of pharmacokinetic interaction between caffeine (300 mg) in three divided doses with sodium valproate (400 mg) and carbamazepine (200 mg) given as single doses, in normal human volunteers, using a open cross over design. Both the serum concentration of sodium valproate and pharmacoki...
journal_title：Indian journal of experimental biology
pub_type： 临床试验,杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:The use of plants is as old as the mankind. Natural products are cheap and claimed to be safe. They are also suitable raw material for production of new synthetic agents. Rosemary (Rosmarinus officinalis Linn.) is a common household plant grown in many parts of the world. It is used for flavouring food, a beverage dri...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章,评审
doi：
更新日期：1999-02-01 00:00:00
abstract：:Thermoactinomycetes vulgaris is a thermophilic actinomycetes growing optimally at 50 degrees C and Streptomyces albus, S. coelicolor, S. fasciculus and S. olivochromogenes are thermophilically disposed transition species of actinomycetes, which have optimum biomass at 40 degrees C. The acid/alkaline phosphatase and ac...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1997-05-01 00:00:00
abstract：:By using multiple-choice technique, mating success between purple eye colour mutant and wild type D. biarmipes was studied in an Elens-Wattiaux mating chamber. Red eyed (wild type) males were more successful in mating than mutant males. However, mutant females were more receptive than wild females. The results suggest...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1993-11-01 00:00:00
abstract：:Role of cell replication on aflatoxin B1 (AFB1) induced hepatocarcinogenesis was investigated in neonatal rats showing persistence of cell replication in the liver for 21 days of post natal life. Adult (8-10 weeks old) rats displaying no hepatocytic proliferation served as controls. Three doses of AFB1 were administer...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1992-03-01 00:00:00
abstract：:Wheat peptides (0.5 to 3 KDa M(r)) mimick hormonal activity like that of gibberellins and forced open dark closed stomata. The deionized amphoteric peptides solution after passing through cation and anion exchanger resins was run through Amicon's ultrafilters, 10, 3 and 0.5 kDa (M(r)) cut off system. The 3 to 0.5 kDa ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
abstract：:The Internet is a massive expanding body of information, which is likely to play a significant role for clinicians and researchers across the world. Since its inception in December 1969 the Internet has grown rapidly and is anticipated to expand 1,000% in the coming next few years. Various useful databases on human ge...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章,评审
doi：
更新日期：2001-06-01 00:00:00
abstract：:In the present study, anti-proliferative effects of dietary polyphenolic compounds have been observed and demonstrated the strong anticancer efficacy of curcumin (CMN), an active constituent of dietary spice (turmeric) using human leukemia cancer cell line. CMN inhibited the proliferation of K562 leukemic cells by ind...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2006-03-01 00:00:00
abstract：:Tadpoles of B. melanostictus and R. cyanophlyctis were reared in vitamin A solution. Rearing of the tadpoles of B. melanostictus in solutions containing 15, 20 and 30 IU/ml vitamin A palmitate resulted in complete disappearance of the keratinized epidermal material over the jaws and horny labial teeth. However tadpole...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1994-07-01 00:00:00
abstract：:Effects of sublethal doses of metal (Cu, Cd, Zn) mixtures on the activities of key respiratory enzymes (succinate dehydrogenase, SDH and glyceraldehyde dehydrogenase, GDH) and their recovery following withdrawal of treatments were studied in the freshwater fish O. mossambicus. On the basis of 96 hr LC50 Cu was highly ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1992-06-01 00:00:00
abstract：:Lipopolysaccharide (LPS) and ratio-detoxified LPS (Rd-LPS) from Salmonella typhimurium were analysed for their ability to stimulate murine peritoneal exudate cells (PEC) and macrophages. Rd-LPS induced much more inflammatory response as compared to LPS. PEC numbers/mouse obtained were significantly higher (3-fold) in ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1999-03-01 00:00:00
abstract：:The frequency and types of acrocentric chromosome association were quantitatively analysed in a Down syndrome child with unusual karyotype, 46, XX, -14, -22, t dic (14p;22p), +21, 21S+. Father and 4 sibs were heterozygous carriers for t dic (14p;22p). The variant 21S+ was inherited from the mother. The occurrence of t...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1990-06-01 00:00:00
abstract：:A study to monitor marine pollution with reference to trace elements (Fe, Zn, Mn and Cu) on T. attenuata, commonly called as screw shell over a period of one year on the whole body and various organs, viz. digestive diverticula, foot, mantle and ovary was conducted from the sandy beach of Porto Novo Coast (Lat 11 degr...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1999-11-01 00:00:00
abstract：:Pups (5 days old) were undernourished by separating them for 14 hr daily from their mothers for 7, 10, 13, 16 and 20 days. The undernourished rats showed significant decrease in body and brain weight, protein and nucleic acid contents at all stages of observation as compared to controls. The activities of SDH and AChE...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1990-09-01 00:00:00
abstract：:Biotin deficiency produced by feeding raw egg white caused decrease in the concentration of many glycosaminoglycans (GAG) in the aorta in rats fed standard laboratory diet and atherogenic diet. This decrease has been observed to be due to the increased activity of enzymes involved in the degradation of GAG and glycohy...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1993-02-01 00:00:00
abstract：:Seven L. acidophilus strains were examined for their antibiotic sensitivity against various chemotherapeutic agents and all of them were found to be sensitive to novobicin, chloramphenicol, ampicillin, erythromycin, oxytetracycline and chlorotetracycline, whereas, all were resistant to norfloxacin and nalidixic acid. ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1995-08-01 00:00:00
abstract：:A cobalt-resistant wall-less mutant of N. crassa (Cor-sl) characterized previously was also found to be 3-fold more resistant to nickel when compared to the parent wall-less mutant (W-sl). The Cor-sl strain accumulates relatively lower amounts of nickel when compared to W-sl. Sub-cellular fractionation showed signific...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2004-11-01 00:00:00
abstract：:Incidence of obesity and diabetes is increasing at an alarming rate not only among the populations of the affluent nations but also amongst the populations of the developing nations. Understanding the mechanisms that cause the onset of these pathological conditions is a requisite to effectively tackling this problem. ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章,评审
doi：
更新日期：2000-09-01 00:00:00
abstract：:Ascorbic acid treatment in arsenic trioxide treated rats increased arsenic excretion, inhibited lipid peroxidation, improved GSH status, regulated GSSG turnover and also restored glutathione-S-transferases activity in liver and kidney. Suitable mechanisms leading to ascorbic acid protection have been discussed. Upregu...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2007-04-01 00:00:00
abstract：:Cimetidine has been demonstrated to impair microsomal oxidative drug metabolizing and other enzyme systems in mouse liver. The inhibition is rapid, occurring after a single administration and also found to be dose-dependent. It is more significant after daily administration for 15 days. Enzyme inhibition by ranitidine...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1991-09-01 00:00:00
abstract：:Spirulina platensis treatment (400 mg kg(-1) for 25 days) effectively suppressed peripheral sensitization via modulation of glial activation and improved motor coordination and restoration of functional motor activity in collagen-induced arthritic rats. Spirulina treatment also resulted in an appreciable reduction of ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2011-10-01 00:00:00
