Aflatoxin B1 induced hepatocarcinogenesis in neonatal rats.

Abstract:

:Role of cell replication on aflatoxin B1 (AFB1) induced hepatocarcinogenesis was investigated in neonatal rats showing persistence of cell replication in the liver for 21 days of post natal life. Adult (8-10 weeks old) rats displaying no hepatocytic proliferation served as controls. Three doses of AFB1 were administered to both the groups at intervals of 48 hr with the doses starting on 10th day of age in the neonatal group. Appearance of phenotypically altered preneoplastic hepatocytes was quantitated in both the groups. A significantly higher incidence of preneoplastic foci was recorded in neonatal rats as compared to adult animals. The results suggest that presence of cell replication in neonatal rats at the time of AFB1 administration enhances the process of hepatocarcinogenesis.

journal_name

Indian J Exp Biol

authors

Mathur M,Rizvi TA,Nayak NC

keywords:

subject

Has Abstract

pub_date

1992-03-01 00:00:00

pages

165-8

issue

3

eissn

0019-5189

issn

0975-1009

journal_volume

30

pub_type

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