Abstract:
:Toxoplasmosis is a widely distributed disease caused by the protozoan Toxoplasma gondii that is mainly transmitted orally. Once ingested, the parasite crosses the intestinal barrier to reach the blood and lymph systems to migrate to other regions of the host. The objective of this study was to evaluate the changes in the myenteric plexus and the jejunal wall of Wistar rats caused by oral infection with T. gondii oocysts (ME-49 strain). Inocula of 10, 100, 500 and 5000 oocysts were used. The total population of myenteric neurons and the most metabolically active subpopulation (NADH-diaphorase positive - NADH-dp) exhibited a decrease proportional to the dose of T. gondii. There was also a quantitative increase in the subpopulation of NADPH-diaphorase-positive (NADPH-dp) myenteric neurons, indicating greater expression of the NOS enzyme. Neuronal atrophy was observed, and morphological and morphometric alterations such as jejunal atrophy were found in the infected groups. Hypertrophy of the external muscle with the presence of inflammatory foci was observed in the group infected with 5000 oocysts. The changes observed in the infected groups were proportional to the number of oocysts inoculated.
journal_name
Exp Parasitoljournal_title
Experimental parasitologyauthors
Vicentino-Vieira SL,Nogueira de Melo Gde A,Biondaro Góis M,Martins Moreira N,de Araujo Pereira LG,de Almeida Araújo EJ,Garcia JL,de Mello Gonçales Sant'Ana Ddoi
10.1016/j.exppara.2015.05.007subject
Has Abstractpub_date
2015-09-01 00:00:00pages
12-8eissn
0014-4894issn
1090-2449pii
S0014-4894(15)00131-9journal_volume
156pub_type
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