Abstract：
:Nitazoxanide (NTZ) is a broad-spectrum anti-parasitic drug used against a wide variety of protozoans and helminthes. Albendazole, its active metabolite albendazole sulfoxide (ABZSO), is one of the drugs of choice to treat both intestinal and tissue helminth and protozoan infections. However little is known regarding their impact on the metabolism of parasites. The aim of this study was to compare the in vitro effect of NTZ and ABZSO in the glycolysis of Taenia crassiceps cysticerci. The cysticerci were treated with 1.2; 0.6; 0.3 or 0.15 μg/mL of NTZ or ABZSO. Chromatographic and spectrophotometric analyses were performed in the culture medium and in the cysticerci extract. Regarding the glucose concentrations was possible to observe two responses: impair of the uptake and gluconeogenesis. The pyruvate concentrations were increased in the ABZSO treated group. Lactate concentrations were increased in the culture medium of NTZ treated groups. Therefore it was possible to infer that the metabolic acidosis was greater in the group treated with NTZ than in the ABZSO treated group indicating that this is one of the modes of action used by this drug to induce the parasite death.
journal_name
Exp Parasitoljournal_title
Experimental parasitologyauthors
Isac E,de A Picanço G,da Costa TL,de Lima NF,de S M M Alves D,Fraga CM,de S Lino Junior R,Vinaud MCdoi
10.1016/j.exppara.2016.10.012subject
Has Abstractpub_date
2016-12-01 00:00:00pages
17-22eissn
0014-4894issn
1090-2449pii
S0014-4894(16)30248-Xjournal_volume
171pub_type
杂志文章abstract：:Molecular characterizations of Cryptosporidium spp. in ruminants reared under traditional animal management systems are scarce and studies conducted thus far have revealed largely an absence of the pathogenic and zoonotic species Cryptosporidium parvum in pre-weaned animals. In this study, we examined Cryptosporidium ...
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pub_type： 杂志文章
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journal_title：Experimental parasitology
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journal_title：Experimental parasitology
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