abstract：:Fasciolosis in ruminants is a relentless constraint in the livestock industry across the world. Immuno-prophylactic vaccines against fasciolosis may not come up in near future, rendering the control of this scourge with chemotherapy and snail population control. With the alarming threats of anti-fasciolid drug resista...

journal_title：Experimental parasitology

authors： Lalrinkima H,Lalchhandama C,Jacob SS,Raina OK,Lallianchhunga MC

更新日期：2021-01-12 00:00:00

abstract：:Leishmaniasis is one of the most neglected tropical infectious diseases in the world. The emergence of drug resistance and toxicity and the high cost of the available drugs with a lack of new anti-leishmanial drugs highlight the need to search for newer therapies with anti-leishmanial activities. Due to the mesenchyma...

journal_title：Experimental parasitology

authors： Bahrami S,Safari M,Razi Jalali MH,Ghorbanpoor M,Tabandeh MR,Rezaie A

更新日期：2021-01-04 00:00:00

abstract：:The aim of the current investigation was to assess the impacts of methanolic extract of Allium sativum (MEAS) on IL-4 (a cytokine derived from Th2 cells) and IFN-ɣ (a cytokine derived from Th1 cells) levels in mice infected with Echinococcus granulosus. Sixty healthy BALB/c female mice were used in this study. Each an...

journal_title：Experimental parasitology

authors： Shirgholami Z,Borji H,Mohebalian H,Heidarpour M

更新日期：2021-01-01 00:00:00

abstract：:Infection with Leishmania infantum causes the disease visceral leishmaniasis (VL), which is a serious clinical and veterinary problem. The drugs used to treat canine leishmaniasis (CanL) do not cause complete parasite clearance; they can be toxic, and emerging drug resistance in parasite populations limits their clini...

journal_title：Experimental parasitology

authors： Miret JA,Moreno J,Nieto J,Carter KC,Mullen AB,Ambros L,Rodríguez C,San Andrés MI,González F

更新日期：2021-01-01 00:00:00

abstract：:Strongyloidiasis is a parasitosis that represents a public health problem, in tropical regions. The present study aimed to investigate the anthelmintic effects of several extracts of Argemone mexicana, as well as its main component berberine (Ber) against the third-stage larvae (L3) of Strongyloides venezuelensis in-v...

journal_title：Experimental parasitology

authors： Elizondo-Luévano JH,Castro-Ríos R,López-Abán J,Gorgojo-Galindo O,Fernández-Soto P,Vicente B,Muro A,Chávez-Montes A

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:American cutaneous leishmaniasis (ACL) is caused by different Leishmania parasites, which stimulate and direct the immune response against the infection. OBJECTIVE:To evaluate the TaqMan probe technology applicability to diagnose and identifying of Leishmania spp. related to the ACL etiology. METHODOLOGY:T...

journal_title：Experimental parasitology

authors： Morais RCS,Melo MGN,Goes TC,Pessoa E Silva R,Morais RF,Guerra JAO,Brito MEF,Brandão-Filho SP,Paiva Cavalcanti M

更新日期：2020-12-01 00:00:00

abstract：:Trichinella spiralis (T. spiralis) muscle larvae (ML) excretory/secretory products (ESPs) are antitumor substances extracted from the culture medium of T. spiralis ML. The ESPs inhibit tumor growth and induce tumor cell apoptosis. To explore the effects of these products on the non-small-cell lung cancer (NSCLC) line ...

journal_title：Experimental parasitology

authors： Wu H,Li M,Shao X,An Z,Du J,Yin H,Pan J,Li S,Zhang Y,Du L

更新日期：2020-11-01 00:00:00

abstract：:Acacia farnesiana pods are rich in secondary metabolites and their biological activities have been recorded as antibacterial, antioxidant and anthelmintic. Previously, an in vitro bioguided study showed the important ovicidal and larvicidal effects of an organic fraction (EtOAc-F) from a hydroalcoholic extract of A. f...

journal_title：Experimental parasitology

authors： Olmedo-Juárez A,Zarza-Albarran MA,Rojo-Rubio R,Zamilpa A,González-Cortazar M,Mondragón-Ancelmo J,Rivero-Pérez N,Mendoza-de Gives P

更新日期：2020-11-01 00:00:00

abstract：PURPOSE:Praziquantel (PZQ) is the conventional antibilharzial agent. Nevertheless, no antibilharzial prophylactic agents or 100% curable therapy approved and no reported data about use of human CD34+ Umbilical Cord Blood Stem Cells (CD34+UCBSCs) or Wharton Jelly Mesenchymal Stem Cells (WJMSCs) in prevention and/or comp...

journal_title：Experimental parasitology

authors： Magdy M,Fahmy A,Zaki NI,Mohamed AK

更新日期：2020-10-01 00:00:00

abstract：:Complex life cycle parasites can manipulate the behavior of intermediate hosts in order to reduce their fitness and increase the chance of completing life cycle. In order to understand the effects of the trematode parasites of the genus Clinostomum on host fish Loricariichthys platymetopon, a filmed experiment was car...

journal_title：Experimental parasitology

authors： Nicola DN,Affonso IP,Takemoto RM

更新日期：2020-09-01 00:00:00

abstract：:Distinct antigens have been evaluated with diagnostic purpose for canine and human visceral leishmaniasis (VL), and variable sensitivity and specificity values have been obtained in the assays. In the present study, a Leishmania infantum hypothetical protein called LiHyG, which was identified in an immunoproteomics st...

journal_title：Experimental parasitology

authors： Machado AS,Ramos FF,Santos TTO,Costa LE,Ludolf F,Lage DP,Bandeira RS,Tavares GSV,Oliveira-da-Silva JA,Steiner BT,Chaves AT,Oliveira JS,Chávez-Fumagalli MA,de Magalhães-Soares DF,Silveira JAG,Duarte MC,Machado-de-Ávila RA

更新日期：2020-09-01 00:00:00

abstract：:The search for novel therapeutic candidates against animal trypanosomiasis is an ongoing scientific endevour because of the negative impacts of the disease to the African livestock industry. In this study, the in vivo therapeutic potentials of phytol toward Trypanosoma congolense infection and the inhibitory effects o...

journal_title：Experimental parasitology

authors： Saad SB,Ibrahim MA,Jatau ID,Shuaibu MN

更新日期：2020-09-01 00:00:00

abstract：:Rhipicephalus microplus, the cattle tick, is a major cause of economic losses in bovine production. Due to the widespread acaricidal resistance to commercially available products, as well as their toxicity and environmental impact, alternative control methods are required. Nanoformulations produced from plant extracts...

journal_title：Experimental parasitology

authors： Nogueira JAP,Figueiredo A,Duarte JL,de Almeida FB,Santos MG,Nascimento LM,Fernandes CP,Mourão SC,Toscano JHB,Rocha LM,Chagas ACS

更新日期：2020-08-01 00:00:00

abstract：:According to the World Health Organization, lymphatic filariasis (LF), a mosquito-borne neglected tropical disease (NTD), should be eliminated as a public health concern by the end of 2020. To this end, the goals of the Global Programme to Eliminate Lymphatic Filariasis (GPELF) include interrupting transmission throug...

journal_title：Experimental parasitology

authors： Albuquerque AL,Araújo TA,Melo DCTV,Paiva MHS,Melo FL,Oliveira CMF,Ayres CFJ

更新日期：2020-08-01 00:00:00

abstract：:Non-invasive small animal in vivo imaging is an essential tool in a broad variety of biomedical sciences and enables continuous monitoring of disease progression in order to develop and improve diagnostic, therapeutic and preventive measures. Imaging parasites non-invasively in live animals allows efficient parasite d...

journal_title：Experimental parasitology

authors： Novobilský A,Höglund J

更新日期：2020-07-01 00:00:00

abstract：:Chagas disease, also known as American trypanosomiasis, is a potentially life-threatening illness caused by the protozoan parasite Trypanosoma cruzi, which is transmitted by insects of the family Reduviidae. Since conventional treatments with nitroheterocyclic drugs show serious adverse reactions and have questionable...

journal_title：Experimental parasitology

authors： Sáenz-Garcia JL,Yamanaka IB,Pacheco-Lugo LA,Miranda JS,Córneo ES,Machado-de-Ávila RA,De Moura JF,DaRocha WD

更新日期：2020-03-01 00:00:00

abstract：:Toxoplasma gondii is a protozoan parasite of great importance in human and veterinary health. The frontline treatment of antifolates suffers a variety of drawbacks, including toxicity and allergic reactions, underscoring the need to identify novel drug targets for new therapeutics to be developed. We previously showed...

journal_title：Experimental parasitology

authors： Hanquier J,Gimeno T,Jeffers V,Sullivan WJ Jr

更新日期：2020-02-28 00:00:00

abstract：:Chryseobacterium indologenes and Chryseobacterium gleum are Gram negative environmental bacteria that have been frequently reported to implicate in fatal nosocomial infections, such as bacteraemia and ventilator-associated pneumonia in immunocompromised individuals in the past decades. The interaction between Chryseob...

journal_title：Experimental parasitology

authors： Lim WG,Tong T,Chew J

更新日期：2020-02-19 00:00:00

abstract：:Typically, antimicrobial peptides (AMPs) are short positive charged peptides serving a key role in innate immunity as well as antimicrobial activity. Discovering novel therapeutic agents is considered as an undeniable demand due to increasing microbial species with antibiotic resistance. In this direction, the unique ...

journal_title：Experimental parasitology

authors： Zahedifard F,Lee H,No JH,Salimi M,Seyed N,Asoodeh A,Rafati S

更新日期：2020-02-01 00:00:00

abstract：:Giardia duodenalis is one of the most important intestinal parasites globally, especially in children, and in Cuba is the leading cause of chronic paediatric diarrhoea in this population. G. duodenalis is composed of eight genetic groups (or assemblages), two of which (A and B) are apparently zoonotic, occurring in bo...

journal_title：Experimental parasitology

authors： Jerez Puebla LE,Núñez Fernández FA,Fraga J,Rivero LR,Millán IA,Valdés LA,Silva IM,Müller N,Robertson LJ

更新日期：2020-02-01 00:00:00

abstract：:Canine leishmaniosis due to Leishmania infantum is a widespread zoonotic disease. Although aminosidine can be an effective treatment, current therapeutic recommendations do not advocate its use, mainly due to concerns regarding the potential nephrotoxicity and ototoxicity of this drug. The aim of this randomized, blin...

journal_title：Experimental parasitology

authors： Kasabalis D,Chatzis MK,Apostolidis K,Xenoulis PG,Buono A,Petanides T,Leontides LS,Polizopoulou ZS,Steiner JM,Suchodolski JS,Saridomichelakis MN

更新日期：2019-11-01 00:00:00

abstract：:Two experiments were performed to determine whether oral administration of copper oxide capsules controlled helminthic infections in Lacaune sheep without acute collateral effects on animal health. In experiment 1, 48 multiparous lactating sheep (60.1 ± 8.5 kg) were stratified according to initial number of eggs (Haem...

journal_title：Experimental parasitology

authors： Campigotto G,Gebert RR,Santos DS,Dos Reis JH,Alba DF,Cazarotto CJ,Leal MLR,Baldissera MD,Lopes TF,Druzian LT,Morsch VM,Vedovatto M,Da Silva AS

更新日期：2019-10-01 00:00:00

abstract：:Monoclonal antibodies have a wide range of applications in basic and applied research as well as in the medical and pharmaceutical industries. Phage display antibody libraries offer an alternative to hybridoma technology for the generation of monoclonal antibodies and can be applied to high-throughput screening and fa...

journal_title：Experimental parasitology

authors： Norbury LJ,Basałaj K,Bąska P,Zawistowska-Deniziak A,Kalinowska A,Wilkowski P,Wesołowska A,Wędrychowicz H

更新日期：2019-10-01 00:00:00

abstract：:Only two drugs are currently available for the treatment of Chagas disease and their effectiveness are unsatisfactory. Photorhabdus luminescens and Xenorhabdus nematophila, two enteric bacteria highly pathogenic to a broad range of insects, have been studied as potential source for bioactive metabolites against protoz...

journal_title：Experimental parasitology

authors： Antonello AM,Sartori T,Silva MB,Prophiro JS,Pinge-Filho P,Heermann R,da Silva OS,Romão PRT

更新日期：2019-09-01 00:00:00

abstract：:Toxoplasma gondii is an opportunistic zoonotic protozoan that exceeds neurological and congenital impact sequence to reactivating latent toxoplasmosis especially under immunosuppression. Sex-associated hormones influence the severity of Toxoplasma infection. Thus, our study aimed to compare toxoplasmosis associated mo...

journal_title：Experimental parasitology

authors： Hegazy MM,Elmehankar MS,Azab MS,El-Tantawy NL,Abdel-Aziz A

更新日期：2019-07-01 00:00:00

abstract：:Trypanosoma congolense is an important pathogen that wreaks havoc in the livestock industry of the African continent. This study evaluated the in vivo antitrypanosomal activity of geranylacetone and its ameliorative effect on the disease-induced anaemia and organ damages as well as its inhibitory effects against trypa...

journal_title：Experimental parasitology

authors： Saad SB,Ibrahim MA,Jatau ID,Shuaibu MN

更新日期：2019-06-01 00:00:00

abstract：:The aim of this study was to observe the intestinal mucosal/systemic responses triggered by intranasal vaccination using recombinant Trichinella spiralis serine protease (rTsSP) and its capacity to elicit immune protection against larva challenge in a murine model. rTsSP coupled with cholera toxin B subunit (CTB) was ...

journal_title：Experimental parasitology

authors： Sun GG,Lei JJ,Ren HN,Zhang Y,Guo KX,Long SR,Liu RD,Jiang P,Wang ZQ,Cui J

更新日期：2019-06-01 00:00:00

abstract：:Human African trypanosomosis (HAT) and animal African trypanosomosis (AAT) are diseases of economic importance in humans and animals that affect more than 36 African countries. The currently available trypanocidal drugs are associated with side effects, and the parasites are continually developing resistance. Thus, ef...

journal_title：Experimental parasitology

authors： Molefe NI,Musinguzi PS,Kondoh D,Watanabe K,Thekisoe OMM,Xuan X,Inoue N,Suganuma K

更新日期：2019-04-01 00:00:00

abstract：:Extracting genomic DNA of pathogenic agents from formalin-fixed specimens is inherently difficult. Storage of samples in formalin results in nucleic acid cross-linking and DNA fragmentation. In this study, DNA was extracted from 45 Giardia-positive stool samples stored in formalin and subjected to PCR amplification ta...

journal_title：Experimental parasitology

authors： Lee MF,Lindo JF,Auer H,Walochnik J

更新日期：2019-03-01 00:00:00

abstract：:Previous studies showed that Echinococcus granulosus infection reduces allergic airway inflammation in experimentally infected hosts and the cystic fluid of E. granulosus is known to activate regulatory T (CD4+CD25+Foxp3+T, Treg) cells. To evaluate the effects of cystic fluid of E. granulosus on allergic airway inflam...

journal_title：Experimental parasitology

authors： Kim HJ,Kang SA,Yong TS,Shin MH,Lee KJ,Park GM,Suvonkulov U,Yu HS

更新日期：2019-03-01 00:00:00

abstract：:Spent mushroom compost (SMC) is a residue generated in edible mushrooms production, such as Hypsizygus marmoreus. Its genome was recently sequenced, demonstrating cuticle-degrading protease genes. The present work aims to investigate the proteases from H. marmoreus spent mushroom compost (SMC) by verifying its action ...

journal_title：Experimental parasitology

authors： Soares FEF,Nakajima VM,Sufiate BL,Satiro LAS,Gomes EH,Fróes FV,Sena FP,Braga FR,de Queiroz JH

更新日期：2019-02-01 00:00:00

abstract：:The intraerythrocytic malaria parasite digests haemoglobin to provide amino acids for metabolism and releases toxic haem that is sequestered into haemozoin, a non-toxic, insoluble, crystalline pigment. Following erythrocyte rupture, haemozoin is released into circulation and phagocytosed by monocytes. Phagocytosed hae...

journal_title：Experimental parasitology

authors： Cumming BM,Goldring JPD

更新日期：2019-02-01 00:00:00

abstract：:Serine proteases have been identified as important molecules that are involved in many parasitic infections, and these molecules have also been suggested to play important roles in Trichinella spiralis infections. In the present study, the antigenic serine protease gene Ts-ADSp-7, which was screened from a cDNA librar...

journal_title：Experimental parasitology

authors： Gao H,Tang B,Bai X,Wang L,Wu X,Shi H,Wang X,Liu X,Liu M

更新日期：2018-12-01 00:00:00

abstract：:The mechanisms underlying metronidazole (MTZ) resistance in Giardia duodenalis have been associated with decreased activity of the enzymes implicated in its activation including nitroductase-1, thioredoxin reductase and pyruvate-ferredoxin oxidoreductase (PFOR). MTZ activation generates radicals that can form adducts ...

journal_title：Experimental parasitology

authors： Ordoñez-Quiroz A,Ortega-Pierres MG,Bazán-Tejeda ML,Bermúdez-Cruz RM

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Among different leishmanial infections, visceral leishmaniasis (VL) if not treated is the most severe form with high mortality rates. In India, it is caused by the protozoan parasite Leishmania donovani. The therapy of visceral leishmaniasis is limited due to high toxicity, resistance to existing drugs and i...

journal_title：Experimental parasitology

authors： Singh N,Chauhan IS

更新日期：2018-10-01 00:00:00

abstract：:The role of oxidative stress in the pathogenicity of acanthamoebiasis is an important aspect of the intricate and complex host-parasite relationship. The aim of this experimental study was to determine oxidative stress through the assessment of lipid peroxidation product (LPO) levels and antioxidant defense mechanism ...

journal_title：Experimental parasitology

authors： Łanocha-Arendarczyk N,Baranowska-Bosiacka I,Gutowska I,Kot K,Metryka E,Kosik-Bogacka DI

更新日期：2018-10-01 00:00:00

abstract：:Galactokinase catalyses the ATP-dependent phosphorylation of galactose. A galactokinase-like sequence was identified in a Fasciola hepatica EST library. Recombinant expression of the corresponding protein in Escherichia coli resulted in a protein of approximately 50 kDa. The protein is monomeric, like galactokinases f...

journal_title：Experimental parasitology

authors： Zinsser VL,Cox C,McAuley M,Hoey EM,Trudgett A,Timson DJ

更新日期：2018-09-01 00:00:00

abstract：:Amoebae from the genus Acanthamoeba are facultative pathogens of humans and other animals. In humans they most frequently infect the eye causing a sight threatening infection known as Acanthamoeba keratitis (AK), and also cause an often fatal encephalitis (GAE). A mannose-binding protein (MBP) has been identified as b...

journal_title：Experimental parasitology

authors： Kang AY,Park AY,Shin HJ,Khan NA,Maciver SK,Jung SY

更新日期：2018-09-01 00:00:00

abstract：:Schistosomiasis remains a global health problem. In the Mekong river basin, approximately 80,000 people are at risk of infection by Schistosoma mekongi. The parasite's eggs become entrapped in the host's organs and induce massive inflammation, contributing to the pathogenesis of schistosomiasis. In addition, egg antig...

journal_title：Experimental parasitology

authors： Thiangtrongjit T,Adisakwattana P,Limpanont Y,Dekumyoy P,Nuamtanong S,Chusongsang P,Chusongsang Y,Reamtong O

更新日期：2018-08-01 00:00:00

abstract：:Due to the occurrence of genetic recombination, a reliable and discriminatory method to genotype Cryptosporidium isolates at the intra-species level requires the analysis of multiple loci, but a standardised scheme is not currently available. A workshop was held at the Robert Koch Institute, Berlin in 2016 that gather...

journal_title：Experimental parasitology

authors： Chalmers RM,Pérez-Cordón G,Cacció SM,Klotz C,Robertson LJ,participants of the Cryptosporidium genotyping workshop (EURO-FBP).

更新日期：2018-08-01 00:00:00