Abstract：
:Cardiac beta-adrenergic receptors' function was studied in the acute phase of Chagas' disease in mice reinfected with Trypanosoma cruzi Tulahuen strain (Tul) and with parasites isolated from an infected patient (SGO-Z12). Genetic characterization of SGO-Z12 isolates demonstrated that it belongs to the zimodeme Z12, one of the prevalent ones in humans in Argentina. Electrocardiography, heart histopathology, parasitemias, and survival in infected and reinfected mice were also analyzed. Reinfected mice reached higher parasitemias, 14% of the infected with SGO-Z12 and 76% of the reinfected groups showed electrocardiographic abnormalities. Similar results were found in mice that were infected and reinfected with Tul. SGO-Z12-Reinfected and Tul-Infected groups exhibited cardiac beta-adrenergic receptors' affinity significantly diminished (p<0.001) and its density significantly increased (p<0.001) than in infected and non-infected groups. Histopathologic alterations in hearts from Tul and SGO-Z12-Reinfected mice were detected. Reinfections with T. cruzi, Tulahuen strain or SGO-Z12 isolate provoked cardiac dysfunctions of different degrees, from the acute phase on.
journal_name
Exp Parasitoljournal_title
Experimental parasitologyauthors
Bustamante JM,Rivarola HW,Fernández AR,Enders JE,Ricardo F,d'Oro Gloria DL,Palma JA,Paglini-Oliva PAdoi
10.1016/s0014-4894(03)00096-1keywords:
subject
Has Abstractpub_date
2003-03-01 00:00:00pages
136-42issue
3-4eissn
0014-4894issn
1090-2449pii
S0014489403000961journal_volume
103pub_type
杂志文章abstract：:Angiostrongylus cantonensis causes eosinophilic meningitis and eosinophilic pleocytosis in humans and is of significant socio-economic importance globally. microRNAs (miRNAs) are endogenous small non-coding RNAs that play crucial roles in gene expression regulation, cellular function and defense, homeostasis and patho...
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journal_title：Experimental parasitology
pub_type： 杂志文章
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doi：10.1016/j.exppara.2016.07.004
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doi：10.1016/j.exppara.2010.05.013
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更新日期：2013-01-01 00:00:00
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journal_title：Experimental parasitology
pub_type： 杂志文章
doi：10.1016/0014-4894(89)90116-1
更新日期：1989-04-01 00:00:00
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journal_title：Experimental parasitology
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doi：10.1016/j.exppara.2012.12.012
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journal_title：Experimental parasitology
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pub_type： 杂志文章
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journal_title：Experimental parasitology
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abstract：:Culture forms of Leishmania (Leishmania) amazonensis (IFLA/BR/67/PH8) produce an extracellular enzyme that hydrolyzes sucrose molecules into their component monosaccharides. This is important because phlebotomine sand flies, the invertebrate hosts of Leishmania, ingest plant sap or aphid and coccid honeydew rich in su...
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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