Pancreatic hepatocytes in hamsters (Mesocricetus auratus) infected with Trypanosoma cruzi.

Abstract:

:Hepatocytic metaplasia may be induced in hamsters by carcinogens, and associated with aging, diabetes or chronic pancreatitis. By means of histopathologic and immunohistochemic studies, we observed pancreatic hepatocytes in hamsters infected and reinfected with Trypanosoma cruzi. The change was seen in 18 (19%) out of 94 infected animals, and was not found among 53 controls, Normal islet cells were immunoreactive for neuron-specific enolase and not reactive for NCL-HAS. Metaplastic cells were immunoreactive for NCL-HAS and not reactive for islet hormones and enolase. No relationship was observed between number of inoculations and metaplasia; however, the intensity of the inflammatory process and sequels seems to favor the development of metaplastic cells. Hamsters infected with T. cruzi may be useful to study hepatocytic metaplasia, and contribute to clarify aspects of Chagas' disease and pancreatic changes. Our data indicate that aging, in addition to inflammation and atrophy, plays a role in this change.

journal_name

Exp Parasitol

authors

dos Santos VM,de Lima MA,Cabrine-Santos M,Marquez Dde S,Reis Md,Pereira Gde A,Lages-Silva E,Ramírez LE

doi

10.1016/S0014-4894(02)00005-X

keywords:

subject

Has Abstract

pub_date

2002-02-01 00:00:00

pages

103-11

issue

2

eissn

0014-4894

issn

1090-2449

pii

S0014-4894(02)00005-X

journal_volume

100

pub_type

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