Homologues of the 24-kDa flagellar Ca(2+)-binding protein gene of Trypanosoma cruzi are present in other members of the Trypanosomatidae family.

abstract：:Infection with Leishmania infantum causes the disease visceral leishmaniasis (VL), which is a serious clinical and veterinary problem. The drugs used to treat canine leishmaniasis (CanL) do not cause complete parasite clearance; they can be toxic, and emerging drug resistance in parasite populations limits their clini...

journal_title：Experimental parasitology

authors： Miret JA,Moreno J,Nieto J,Carter KC,Mullen AB,Ambros L,Rodríguez C,San Andrés MI,González F

更新日期：2021-01-01 00:00:00

abstract：:The Plasmodium vivax merozoite surface protein-1 (PvMSP-1) has been considered a candidate for a malaria vaccine against erythrocytic stages. PvMSP-1 is immunogenic during natural infections and exhibits antigenic polymorphism. The extent of genetic polymorphism in a region between the so-called interspecies conserved...

journal_title：Experimental parasitology

authors： Gutierrez A,Vicini J,Patarroyo ME,Murillo LA,Patarroyo MA

更新日期：2000-07-01 00:00:00

abstract：:Coccidiosis is a major parasitic disease of poultry industry and an ideal vaccine should induce long-lasting cross-species protective immunity. Broiler chickens (Cobb 500) were inoculated with single, double or triple injections of a synthetic peptide (derived from sequences of Eimeria acervulina and Eimeria tenella a...

journal_title：Experimental parasitology

authors： Talebi A,Mulcahy G

更新日期：2005-08-01 00:00:00

abstract：:The population structure of original Babesia bigemina isolates and reference strains with a defined phenotypic profile was assessed using 18S rRNA and rap-1c genes. Two reference strains, BbiS2P-c (virulent) and BbiS1A-c (low virulence), were biologically cloned in vitro. The virulence profile of the strains and clone...

journal_title：Experimental parasitology

authors： Thompson C,Baravalle ME,Valentini B,Mangold A,Torioni de Echaide S,Ruybal P,Farber M,Echaide I

更新日期：2014-06-01 00:00:00

abstract：:The sphingolipids biosynthesis pathway generates bioactive molecules crucial to the regulation of physiological processes. We have recently reported that DAG (diacylglycerol) generated during sphingomyelin synthesis, plays an important role in PKC (protein kinase C) activation, necessary for the transit through the ce...

journal_title：Experimental parasitology

authors： Cerbon J,Olguin T,Alvarez-Grave PR,López-Sánchez RC

更新日期：2009-06-01 00:00:00

abstract：:We here describe the novel finding that brain endothelial cells in vitro can stimulate the growth of Plasmodium falciparum through the production of low molecular weight growth factors. By using a conditioned medium approach, we show that the brain endothelial cells continued to release these factors over time. If thi...

journal_title：Experimental parasitology

authors： Khaw LT,Ball HJ,Mitchell AJ,Grau GE,Stocker R,Golenser J,Hunt NH

更新日期：2014-10-01 00:00:00

abstract：PURPOSE:Praziquantel (PZQ) is the conventional antibilharzial agent. Nevertheless, no antibilharzial prophylactic agents or 100% curable therapy approved and no reported data about use of human CD34+ Umbilical Cord Blood Stem Cells (CD34+UCBSCs) or Wharton Jelly Mesenchymal Stem Cells (WJMSCs) in prevention and/or comp...

journal_title：Experimental parasitology

authors： Magdy M,Fahmy A,Zaki NI,Mohamed AK

更新日期：2020-10-01 00:00:00

abstract：:Parasites of wildlife inhabiting urbanised and peri-urban environments are of interest regarding wildlife population health, and also veterinary public health in the case of parasites that can also infect humans and domestic animals. This study aimed to: identify, and estimate the prevalence of, species of Eimeria par...

journal_title：Experimental parasitology

authors： Hillman AE,Yang R,Lymbery AJ,Thompson RCA

更新日期：2016-11-01 00:00:00

abstract：:A murine model system was developed to study the induction and mechanism of protective immunity to L3 of Strongyloides stercoralis. L3 were implanted in BALB/cByJ mice in diffusion chambers constructed with 0.1- or 2.0-microns-pore-size membranes. Parasites survived equally well regardless or membrane type for 7 days,...

journal_title：Experimental parasitology

authors： Abraham D,Rotman HL,Haberstroh HF,Yutanawiboonchai W,Brigandi RA,Leon O,Nolan TJ,Schad GA

更新日期：1995-03-01 00:00:00

abstract：:Using [(3)H]inulin uptake as a measure of pharyngeal pumping activity, we have investigated and compared the effects of glutamate, ivermectin, and moxidectin on inulin uptake in susceptible and ivermectin-selected Haemonchus contortus. Inulin uptake is inhibited by glutamate, ivermectin, and moxidectin, at biologicall...

journal_title：Experimental parasitology

authors： Paiement JP,Leger C,Ribeiro P,Prichard RK

更新日期：1999-07-01 00:00:00

abstract：:Trypanosoma cruzi is a rare example of an eukaryote that has genes for two threonine proteases: HslVU complex and 20S proteasome. HslVU is an ATP-dependent protease consisting of two multimeric components: the HslU ATPase and the HslV peptidase. In this study, we expressed and obtained specific antibodies to HslU and ...

journal_title：Experimental parasitology

authors： Barboza NR,Cardoso J,de Paula Lima CV,Soares MJ,Gradia DF,Hangai NS,Bahia MT,de Lana M,Krieger MA,Guerra de Sá R

更新日期：2012-02-01 00:00:00

abstract：:The aim of this study was to develop a simple and reliable method to determine the viability of Giardia intestinalis after incubation with an anti-giardial agent by using a colorimetric method. Factors that may affect the optical density value were systematically evaluated. The most suitable conditions were obtained w...

journal_title：Experimental parasitology

authors： Hounkong K,Sawangjaroen N,Phongpaichit S

更新日期：2011-02-01 00:00:00

abstract：:Entamoeba histolytica infection is associated with considerable morbidity and mortality in the form of intestinal and extraintestinal amoebiasis. No vaccine is yet available for amoebiasis. Heparan Sulphate Binding Proteins (HSBPs) from E. histolytica were evaluated for immunogenicity and protective efficacy in a Guin...

journal_title：Experimental parasitology

authors： Kaur U,Khurana S,Saikia UN,Dubey ML

更新日期：2013-11-01 00:00:00

abstract：:The in vitro growth of Plasmodium falciparum was reduced by 35 and 43% through high concentrations (5 mmole/liter) of magnesium in RPMI medium and magnesium-free medium, respectively, after 48 hr, whereas no significant inhibition could be observed under these conditions after 24 hr cultivation in the respective mediu...

journal_title：Experimental parasitology

authors： Hess FI,Kilian A,Söllner W,Nothdurft HD,Pröll S,Löscher T

更新日期：1995-03-01 00:00:00

abstract：:In this study, human sera reactivity against nine peptides derived from the Toxoplasma gondii P30 protein was assessed by ELISA in patients with different clinical forms of toxoplasmosis. Same as has been reported in mice, sera from congenital, ocular and chronic asymptomatic toxoplasmosis patients recognized more str...

journal_title：Experimental parasitology

authors： Cardona N,de-la-Torre A,Siachoque H,Patarroyo MA,Gomez-Marin JE

更新日期：2009-10-01 00:00:00

abstract：:Cercariae of Schistosoma mansoni produce a wide variety of eicosanoids when stimulated by 3.3 mM linoleate. High-performance liquid chromatography indicated that 10(-5) M esculetin dramatically decreased eicosanoid production by cercariae. Ibuprofen (10(-4) M) also decreased eicosanoid production, but to a lesser exte...

journal_title：Experimental parasitology

authors： Salafsky B,Fusco AC

更新日期：1985-08-01 00:00:00

abstract：:Many methods have been proposed for removing contaminating host cells from mouse peritoneal exudates infected with Toxoplasma gondii tachyzoites. Of these, eight established methods were compared. They were density gradients, sonication and trypsin digestion, differential centrifugation, haemolysin digestion, filtrati...

journal_title：Experimental parasitology

authors： Dempster RP

更新日期：1984-04-01 00:00:00

abstract：:Toxoplasma gondii and the related Apicomplexan protozoan pathogens, Plasmodium, Cryptosporidium, and Eimeria, are obligate intracellular parasites which cause severe disease in their hosts. The recent development of transient transfection of Toxoplasma permits the development of strategies utilizing "reverse genetics"...

journal_title：Experimental parasitology

authors： Kim K,Boothroyd JC

更新日期：1995-02-01 00:00:00

abstract：:Lipophosphoglycan (LPG) is structurally characterized by a series of phosphoglycan repeat units. Cellular LPG, isolated from promastigotes, has a very similar structure to culture supernatant LPG, but differs in the average number of phosphorylated oligosaccharide repeat units and in glycan composition. Comparison of ...

journal_title：Experimental parasitology

authors： Kavoosi G,Ardestani SK,Kariminia A,Alimohammadian MH

更新日期：2010-02-01 00:00:00

abstract：:Twenty-one Trypanosoma cruzi stocks isolated from Triatoma infestans and humans of the Chilean Andean highlands were studied at the genotypic level by schizodeme and molecular karyotype analyses, which allowed a clear distinction of the parasites from those hosts. A phenotypical characterization was performed by prote...

journal_title：Experimental parasitology

authors： Gonzalez J,Muñoz S,Ortiz S,Anacona D,Salgado S,Galleguillos M,Neira I,Sagua H,Solari A

更新日期：1995-08-01 00:00:00

abstract：:Plasmodium falciparum is usually asynchronous during in vitro culture. Highly synchronized cultures of P. falciparum are routinely used in malaria research. Here, we describe a simple synchronization procedure for P. falciparum asexual erythrocytic culture, which involves storage at 4°C for 8-24 h followed by routine ...

journal_title：Experimental parasitology

authors： Yuan L,Hao M,Wu L,Zhao Z,Rosenthal BM,Li X,He Y,Sun L,Feng G,Xiang Z,Cui L,Yang Z

更新日期：2014-05-01 00:00:00

abstract：:In Trypanosoma brucei the GPI-anchored variant surface glycoprotein (VSG) represents approximately 90% of cell surface protein and a major proportion of endoplasmic reticulum (ER) biosynthetic output. We identified four trypanosomatid-specific genes encoding candidate ER-resident proteins; all were required for normal...

journal_title：Experimental parasitology

authors： Wang YN,Wang M,Field MC

更新日期：2010-07-01 00:00:00

abstract：:This study aimed to investigate the effects of diphenyl diselenide (PhSe)2 to treat mice experimentally infected by Toxoplasma gondii on seric biomarkers of cardiac function (creatine kinase, creatine kinase MB, troponin, and myoglobin), and lactate dehydrogenase, as well as to evaluate the enzymatic activity of creat...

journal_title：Experimental parasitology

authors： Machado VS,Bottari NB,Baldissera MD,Isabel de Azevedo M,Rech VC,Ianiski FR,Vaucher RA,Mendes RE,Camillo G,Vogel FF,de la Rue ML,Carmo GM,Tonin AA,Da Silva AS

更新日期：2016-08-01 00:00:00

abstract：:Susceptible A/J and more resistant C57BL/6J mice were infected with Plasmodium chabaudi chabaudi 54X, P.c. chabaudi AS and Plasmodium chabaudi adami 408XZ. As expected, most C57BL/6J mice survived the infections with the different isolates. But in contrast to previous observations, not all A/J mice succumbed to infect...

journal_title：Experimental parasitology

authors： Hernandez-Valladares M,Naessens J,Nagda S,Musoke AJ,Rihet P,Ole-Moiyoi OK,Iraqi FA

更新日期：2004-11-01 00:00:00

abstract：:Protein tyrosine phosphatase of regenerating liver (PRL) is a group of phosphatases that has not been broadly studied in protozoan parasites. In humans, PRLs are involved in metastatic cancer, the promotion of cell migration and invasion. PTPs have been increasingly recognized as important effectors of host-pathogen i...

journal_title：Experimental parasitology

authors： Ramírez-Tapia AL,Baylón-Pacheco L,Espíritu-Gordillo P,Rosales-Encina JL

更新日期：2015-12-01 00:00:00

abstract：:Recent epidemiological evidences revealed the higher prevalence of 'O' blood group in the residents of malaria-endemic areas. Also some data indicated preference of mosquitoes to 'O' group. The aim of this study was to determine ABO group ratio in the residents as well as ABO group preference of Anopheles in two malar...

journal_title：Experimental parasitology

authors： Anjomruz M,Oshaghi MA,Sedaghat MM,Pourfatollah AA,Raeisi A,Vatandoost H,Mohtarami F,Yeryan M,Bakhshi H,Nikpoor F

更新日期：2014-01-01 00:00:00

abstract：:Like most intracellular pathogens, the apicomplexan parasites Besnoitia besnoiti, Toxoplasma gondii and Neospora caninum scavenge metabolites from their host cells. Recruitment of the Golgi complex to the vicinity of the parasitophorous vacuole (PV) is likely to aid in this process. In this work, we comparatively asse...

journal_title：Experimental parasitology

authors： Cardoso R,Wang J,Müller J,Rupp S,Leitão A,Hemphill A

更新日期：2018-04-01 00:00:00

abstract：:Trypanosoma congolense is an important pathogen that wreaks havoc in the livestock industry of the African continent. This study evaluated the in vivo antitrypanosomal activity of geranylacetone and its ameliorative effect on the disease-induced anaemia and organ damages as well as its inhibitory effects against trypa...

journal_title：Experimental parasitology

authors： Saad SB,Ibrahim MA,Jatau ID,Shuaibu MN

更新日期：2019-06-01 00:00:00

abstract：:Toxoplasma gondii is the etiologic agent of toxoplasmosis. Although the combination of sulfadiazine and pyrimethamine is used as therapy for this disease, these drugs can have serious side effects and its use is limited in pregnancy. Therefore there is a need for new anti-T. gondii drugs in the clinic. Some systems fo...

journal_title：Experimental parasitology

authors： Jin C,Kaewintajuk K,Jiang J,Jeong W,Kamata M,Kim HS,Wataya Y,Park H

更新日期：2009-02-01 00:00:00

abstract：:Trypanosoma cruzi is the ethiological agent for Chagas disease in Latin America. This study aimed to test the trypanocidal effect of licarin A and burchellin isolated from plants in northeastern Brazil. These neolignans were tested on T. cruzi and on peritoneal macrophages, to evaluate drug toxicity. Epimastigote grow...

journal_title：Experimental parasitology

authors： Cabral MM,Barbosa-Filho JM,Maia GL,Chaves MC,Braga MV,De Souza W,Soares RO

更新日期：2010-03-01 00:00:00