Abstract:
:Cercariae of Schistosoma mansoni produce a wide variety of eicosanoids when stimulated by 3.3 mM linoleate. High-performance liquid chromatography indicated that 10(-5) M esculetin dramatically decreased eicosanoid production by cercariae. Ibuprofen (10(-4) M) also decreased eicosanoid production, but to a lesser extent. These results were confirmed by radioimmunoassay using time-dose curves for esculetin and time curves for ibuprofen. The results reported here indicated that, for cercariae, ibuprofen was neither a specific cyclo-oxygenase inhibitor, as has been reported for platelet and endothelial cells, nor was esculetin a specific inhibitor of lipoxygenase, as has been reported for platelets and mastocytoma cells. Rather, both drugs inhibited cyclo-oxygenase and lipoxygenase enzyme systems. Further, the data indicated that two forms of cyclo-oxygenase exist in cercariae (isozymes?), one initiating the conversion of gamma-dihomolinolenate into the 1-series prostaglandins and another acting on arachidonate forming the 2-series prostaglandins. The cyclo-oxygenase acting on arachidonate has a greater sensitivity to both ibuprofen and esculetin than the enzyme acting on gamma-dihomolinolenate. Cercarial lipoxygenases also varied greatly in their sensitivity to ibuprofen.
journal_name
Exp Parasitoljournal_title
Experimental parasitologyauthors
Salafsky B,Fusco ACdoi
10.1016/s0014-4894(85)80024-2subject
Has Abstractpub_date
1985-08-01 00:00:00pages
73-81issue
1eissn
0014-4894issn
1090-2449pii
S0014-4894(85)80024-2journal_volume
60pub_type
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journal_title:Experimental parasitology
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pub_type: 杂志文章
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journal_title:Experimental parasitology
pub_type: 杂志文章
doi:10.1016/0014-4894(84)90061-4
更新日期:1984-02-01 00:00:00
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journal_title:Experimental parasitology
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journal_title:Experimental parasitology
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1016/j.exppara.2018.02.008
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journal_title:Experimental parasitology
pub_type: 杂志文章
doi:10.1016/j.exppara.2008.01.008
更新日期:2008-05-01 00:00:00
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journal_title:Experimental parasitology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1986-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.exppara.2017.01.003
更新日期:2017-03-01 00:00:00
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journal_title:Experimental parasitology
pub_type: 杂志文章
doi:10.1016/j.exppara.2014.08.009
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pub_type: 杂志文章
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journal_title:Experimental parasitology
pub_type: 杂志文章
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journal_title:Experimental parasitology
pub_type: 杂志文章
doi:10.1006/expr.1996.0068
更新日期:1996-07-01 00:00:00
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journal_title:Experimental parasitology
pub_type: 杂志文章
doi:10.1016/j.exppara.2011.10.008
更新日期:2012-01-01 00:00:00
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journal_title:Experimental parasitology
pub_type: 杂志文章
doi:10.1016/j.exppara.2007.07.013
更新日期:2008-02-01 00:00:00
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journal_title:Experimental parasitology
pub_type: 杂志文章
doi:10.1016/j.exppara.2017.04.010
更新日期:2017-06-01 00:00:00
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journal_title:Experimental parasitology
pub_type: 杂志文章,评审
doi:10.1016/0014-4894(89)90104-5
更新日期:1989-02-01 00:00:00
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journal_title:Experimental parasitology
pub_type: 杂志文章
doi:10.1016/j.exppara.2008.03.012
更新日期:2008-07-01 00:00:00
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journal_title:Experimental parasitology
pub_type: 杂志文章
doi:10.1016/j.exppara.2006.09.010
更新日期:2007-03-01 00:00:00
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journal_title:Experimental parasitology
pub_type: 杂志文章
doi:10.1016/j.exppara.2009.07.006
更新日期:2009-11-01 00:00:00
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journal_title:Experimental parasitology
pub_type: 杂志文章
doi:10.1016/j.exppara.2013.08.011
更新日期:2013-11-01 00:00:00
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journal_title:Experimental parasitology
pub_type: 杂志文章
doi:10.1016/0014-4894(86)90011-1
更新日期:1986-08-01 00:00:00