Plasmodium vivax: polymorphism in the merozoite surface protein 1 gene from wild Colombian isolates.

Abstract:

:The Plasmodium vivax merozoite surface protein-1 (PvMSP-1) has been considered a candidate for a malaria vaccine against erythrocytic stages. PvMSP-1 is immunogenic during natural infections and exhibits antigenic polymorphism. The extent of genetic polymorphism in a region between the so-called interspecies conserved blocks (ICBs) 2 and 4 of the PvMSP-1 was analyzed in 20 isolates taken from patients from two different areas in Colombia. Variation is unevenly distributed along this gene segment among the isolates. Comparative analysis of these sequences led to the definition of five sequence types (ST1 to 5). ST1 to ST4 exhibit a variation pattern associated with sequences present in the Salvador or Belem sequences. However, ST5 has clusters of sequence that have not been previously described. The changes found along the five variants confirm the important role of recombinational and/or gene conversion events in generating allelic diversity.

journal_name

Exp Parasitol

authors

Gutierrez A,Vicini J,Patarroyo ME,Murillo LA,Patarroyo MA

doi

10.1006/expr.2000.4534

keywords:

subject

Has Abstract

pub_date

2000-07-01 00:00:00

pages

215-9

issue

3

eissn

0014-4894

issn

1090-2449

pii

S0014-4894(00)94534-X

journal_volume

95

pub_type

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