Regulation of immunity in Trypanosoma cruzi infection.

abstract：:Only two drugs are currently available for the treatment of Chagas disease and their effectiveness are unsatisfactory. Photorhabdus luminescens and Xenorhabdus nematophila, two enteric bacteria highly pathogenic to a broad range of insects, have been studied as potential source for bioactive metabolites against protoz...

journal_title：Experimental parasitology

authors： Antonello AM,Sartori T,Silva MB,Prophiro JS,Pinge-Filho P,Heermann R,da Silva OS,Romão PRT

更新日期：2019-09-01 00:00:00

abstract：:There has been some evidence from several parasite systems that proteinases might have potential as protective antigens against parasitic infection. A cysteine proteinase complex identified in the regurgitant of adult F. hepatica was examined in this context. The thiol-cathepsin-related proteinases of M(r) 28,000 were...

journal_title：Experimental parasitology

authors： Wijffels GL,Salvatore L,Dosen M,Waddington J,Wilson L,Thompson C,Campbell N,Sexton J,Wicker J,Bowen F

更新日期：1994-03-01 00:00:00

abstract：:Schistosoma mansoni muscle fibers contract in response to L-glutamate in a dose-dependent manner (10(-6)-10(-3) M). L-aspartate and D-aspartate are likewise effective in eliciting contraction of the fibers. Mammalian glutamate receptor agonists produce little or no contraction at concentrations as high as 1 mM. In add...

journal_title：Experimental parasitology

authors： Miller CL,Day TA,Bennett JL,Pax RA

更新日期：1996-12-01 00:00:00

abstract：:Reliable analytical techniques to test growth-promoting and antimalarial efficacy on plasmodia are very important. Flow cytometry (FCM) offers the possibility to study developmental stages of intraerythrocytic growth of malaria parasites using nucleic acid staining. To analyze the growth of Plasmodium falciparum SYBR ...

journal_title：Experimental parasitology

authors： Izumiyama S,Omura M,Takasaki T,Ohmae H,Asahi H

更新日期：2009-02-01 00:00:00

abstract：:A full-length cDNA encoding the 24-kDa flagellar Ca(2+)-binding protein (FCaBP) of the Dm28c clone of Trypanosoma cruzi was cloned and characterized. Comparison of the deduced amino acid sequence with those of the FCaBPs of other T. cruzi strains revealed greater than 97% sequence conservation. FCaBP-like genes are fo...

journal_title：Experimental parasitology

authors： Maldonado RA,Linss J,Thomaz N,Olson CL,Engman DM,Goldenberg S

更新日期：1997-07-01 00:00:00

abstract：:The cysteine-rich C-terminal region of the merozoite surface protein-1, MSP-119, of Plasmodium falciparum has been the most promising vaccine target antigen to date, based on protective immunization studies with recombinant proteins in mice and monkey models. To be further developed as a vaccine candidate, it is essen...

journal_title：Experimental parasitology

authors： Lalitha PV,Malhotra P,Chattopadhyay R,Chauhan VS

更新日期：1999-05-01 00:00:00

abstract：:In the intestinal tract of fifth instars of the hematophagous reduviid bugs Rhodnius prolixus and Triatoma infestans blood ingestion induced an initial decrease of the concentration of the respective symbiotic bacteria Rhodococcus rhodnii and Nocardia sp. and then within 10 days a 15- or 18-fold increase of the total ...

journal_title：Experimental parasitology

authors： Eichler S,Schaub GA

更新日期：2002-01-01 00:00:00

abstract：:Ticks deposit saliva at the site of their attachment to a host in order to inhibit haemostasis, inflammation and innate and adaptive immune responses. The anti-haemostatic properties of tick saliva have been described by many studies, but few show that tick infestations or its anti-haemostatic components exert systemi...

journal_title：Experimental parasitology

authors： Carvalho WA,Maruyama SR,Franzin AM,Abatepaulo AR,Anderson JM,Ferreira BR,Ribeiro JM,Moré DD,Augusto Mendes Maia A,Valenzuela JG,Garcia GR,de Miranda Santos IK

更新日期：2010-04-01 00:00:00

abstract：:Leishmaniasis, a neglected tropical disease (NTD) causes major health problems in the tropical and subtropical world. Most of the antileishmanial modern therapies with different formulations of pentavalent antimonials, Miltefosine, Amphotericin B etc. are not satisfactory in recent times due to high toxicity to the ho...

journal_title：Experimental parasitology

authors： Paik D,Das P,De T,Chakraborti T

更新日期：2014-11-01 00:00:00

abstract：:Two recombinant barley cystatins, HvCPI5 and HvCPI6, have been tested in vitro against promastigotes and intracellular amastigotes of Leishmania infantum in the J774 monocytic cell line. Toxicity of cystatins for J774 cells was also determined. In addition, a comparison between direct counts of intracellular amastigot...

journal_title：Experimental parasitology

authors： Ordóñez-Gutiérrez L,Martínez M,Rubio-Somoza I,Díaz I,Mendez S,Alunda JM

更新日期：2009-12-01 00:00:00

abstract：:Larvae of Rhinoestrus spp. (Diptera, Oestridae) infect nasal and sinus cavities of horses, causing a nasal myiasis characterized by severe respiratory distress. Presently, the diagnosis of horse nasal botfly relies on the observation of clinical signs, on the post mortem retrieval of larvae or on molecular assays perf...

journal_title：Experimental parasitology

authors： Milillo P,Traversa D,Elia G,Otranto D

更新日期：2010-04-01 00:00:00

abstract：:The present work evaluates the anti-Giardia activity of Syzygium aromaticum and its major compound eugenol. The effects were evaluated on parasite growth, adherence, viability and ultrastructure. S. aromaticum essential oil (IC(50)=134 μg/ml) and eugenol (IC(50)=101 μg/ml) inhibited the growth of G. lamblia. The essen...

journal_title：Experimental parasitology

authors： Machado M,Dinis AM,Salgueiro L,Custódio JB,Cavaleiro C,Sousa MC

更新日期：2011-04-01 00:00:00

abstract：:Malaria caused by the protozoan parasite Plasmodium falciparum, is a major health problem of the developing world. In the present study medicinal plants from Eastern Ghats of South India have been extracted with ethyl acetate and assayed for growth inhibition of asexual erythrocytic stages of chloroquine (CQ)-sensitiv...

journal_title：Experimental parasitology

authors： Kaushik NK,Bagavan A,Rahuman AA,Mohanakrishnan D,Kamaraj C,Elango G,Zahir AA,Sahal D

更新日期：2013-05-01 00:00:00

abstract：:The water-borne protozoan parasite Cryptosporidium parvum forms oocysts that can persist for long periods of time in the environment, even though the sporozoites inside the oocysts may no longer be viable, making it difficult to assess the associated risk of infection. In this study, we compared the ability of various...

journal_title：Experimental parasitology

authors： Vande Burgt NH,Auer A,Zintl A

更新日期：2018-04-01 00:00:00

abstract：:Rabbit coccidiosis caused by members of the genus Eimeria can cause enormous economic impact worldwide, but the genetics, epidemiology and biology of these parasites remain poorly understood. In the present study, we sequenced and annotated the complete mitochondrial (mt) genomes of five Eimeria species that commonly ...

journal_title：Experimental parasitology

authors： Liu GH,Tian SQ,Cui P,Fang SF,Wang CR,Zhu XQ

更新日期：2015-12-01 00:00:00

abstract：:Several species of the genus Leishmania are causative agents of cutaneous leishmaniasis in Pakistan. This study aimed to determine phylogenetic placement of Leishmania species causing cutaneous leishmaniasis in Khyber Pakhtunkhwa province, Pakistan (34 Leishmania tropica, 3 Leishmania infantum), in-relation to species...

journal_title：Experimental parasitology

authors： Khan NH,Messenger LA,Wahid S,Sutherland CJ

更新日期：2016-08-01 00:00:00

abstract：:Trypanosoma cruzi infection in humans and experimental animals often results in a chronic heart and gut inflammation and a dysfunction known as Chagas' disease. Previous studies have shown that the cellular infiltrate in the hearts of animals with chronic Chagas' disease consists mainly of CD8+ T cells. In this study,...

journal_title：Experimental parasitology

authors： Zhang L,Tarleton RL

更新日期：1996-11-01 00:00:00

abstract：:Motility is required for feeding, reproduction and maintenance of the fluke in the host's liver. According to that, the neuromuscular system can be an attractive drugable target for chemotherapy. Musculature of the Fascioloides magna is organized into three layers, an outer circular layer, beneath this layer the longi...

journal_title：Experimental parasitology

authors： Trailović SM,Marinković D,Trailović JN,Milovanović M,Marjanović DS,Aničić MR

更新日期：2015-12-01 00:00:00

abstract：:This is the first report establishing the existence of glycolipids synthesized by plasmodia, in particular Plasmodium falciparum. Trophozoites, schizonts, gametocytes, and gametes were metabolically labeled in vitro with [3H]glucosamine, [3H]galactose, [3H]glucose, [3H]mannose, [3H]fucose, [32P]inorganic phosphate, or...

journal_title：Experimental parasitology

authors： Sherwood JA,Spitalnik SL,Aley SB,Quakyi IA,Howard RJ

更新日期：1986-08-01 00:00:00

abstract：:Among the wide variety of clinicopathological manifestations of intestinal amebiasis, amebomas occur rarely and their pathogenesis is not well understood. When cholesterol-fed, 2- to 4-week-old guinea pigs were infected intracecally with a virulent, monoaxenic strain of Entamoeba histolytica, gross and histologically ...

journal_title：Experimental parasitology

authors： Bhatti HS,Bhushnurmath S,Mahajan RC,Ganguly NK,Sehgal R

更新日期：1992-05-01 00:00:00

abstract：:The aim of this study was to analyze the antioxidant status and oxidative profile in serum and liver of rats experimentally infected with Fasciola hepatica and its relationship with pathological findings. Twenty-four rats were divided into two groups: group A consisted of 12 healthy rats and group B of 12 rats infecte...

journal_title：Experimental parasitology

authors： Bottari NB,Mendes RE,Lucca NJ,Schwertz CI,Henker LC,Olsson DC,Piva MM,Sangoi M,Campos LP,Moresco RN,Jaques JA,Da silva AS

更新日期：2015-12-01 00:00:00

abstract：:Monoclonal antibodies against infective third-stage larvae (L3) of Brugia pahangi were generated from mice immunized with L3 antigens. The monoclonal antibodies were L3 stage-specific or stage-nonspecific. A BpG1 monoclonal antibody (IgG1 subclass) showing L3 stage-specificity was examined in detail. BpG1 recognized t...

journal_title：Experimental parasitology

authors： Oikawa Y,Ikeda T,Horii Y,Fujita K,Tsukidate S

更新日期：1992-08-01 00:00:00

abstract：:This paper describes the in vitro multiplication process of Babesia bigemina sporokinetes in a cell line (IDE8) from Ixodes scapularis ticks. The inoculum was obtained from hemolymph of engorged females of Rhipicephalus (Boophilus) microplus ticks naturally infected with B. bigemina. These ticks had been fed on calves...

journal_title：Experimental parasitology

authors： Ribeiro MF,Bastos CV,Vasconcelos MM,Passos LM

更新日期：2009-07-01 00:00:00

abstract：:Plasmodium falciparum is usually asynchronous during in vitro culture. Highly synchronized cultures of P. falciparum are routinely used in malaria research. Here, we describe a simple synchronization procedure for P. falciparum asexual erythrocytic culture, which involves storage at 4°C for 8-24 h followed by routine ...

journal_title：Experimental parasitology

authors： Yuan L,Hao M,Wu L,Zhao Z,Rosenthal BM,Li X,He Y,Sun L,Feng G,Xiang Z,Cui L,Yang Z

更新日期：2014-05-01 00:00:00

abstract：:Amoebae of the genus Acanthamoeba are free-living protozoa that can cause granulomatous encephalitis and keratitis in humans. In this study, four clinical and three household dust isolates obtained in Vitória, Espírito Santo, Brazil were characterized by their morphological, genotypic, and physiological properties. Al...

journal_title：Experimental parasitology

authors： Duarte JL,Furst C,Klisiowicz DR,Klassen G,Costa AO

更新日期：2013-09-01 00:00:00

abstract：:Spleen cells from BALB/c mice were fused with myeloma cells following infection of the mice with Trichinella spiralis larvae and an ip booster injection with larval homogenate antigen. A monoclonal antibody (Mab), designated as TS 3G6 which did not react with sera or tissue extracts from noninfected mice, rats, and gu...

journal_title：Experimental parasitology

authors： Kehayov IR,Kyurkchiev SD,Tankov CV,Komandarev SK

更新日期：1991-08-01 00:00:00

abstract：:Galactokinase catalyses the ATP-dependent phosphorylation of galactose. A galactokinase-like sequence was identified in a Fasciola hepatica EST library. Recombinant expression of the corresponding protein in Escherichia coli resulted in a protein of approximately 50 kDa. The protein is monomeric, like galactokinases f...

journal_title：Experimental parasitology

authors： Zinsser VL,Cox C,McAuley M,Hoey EM,Trudgett A,Timson DJ

更新日期：2018-09-01 00:00:00

abstract：:In Trichostrongylus colubriformis-infected rabbits, epithelial cell migration rates and cell transit times along the villi were compared by radioautography on histological slides to normal values from noninfected small intestine. Regions of gut with high (upper jejunum) and low (ileum) burdens of worms were both exami...

journal_title：Experimental parasitology

authors： Hoste H,Mariana JC

更新日期：1989-04-01 00:00:00

abstract：:Serine hydroxymethyltransferase belongs to the class of pyridoxal-5-phosphate enzymes along with aspartate aminotransferase. To explore the function of residue(s) involved in binding of the carboxylate group of Tetrahydrofolic acid (THF) to L. donovani cytosolic serine hydroxymethyltransferase (LdcSHMT), the gene was ...

journal_title：Experimental parasitology

authors： Gandhi S,Gaur N,Krishna S,Siddiqi MI,Saxena JK

更新日期：2015-02-01 00:00:00

abstract：:To better control gastrointestinal nematode infections in humans and animals, it is important to understand the strategies used by these parasites to modulate the host immune system. In this regard, molecules released by parasites have been attributed crucially important roles in host-parasite negotiations. We charact...

journal_title：Experimental parasitology

authors： Tritten L,Tam M,Vargas M,Jardim A,Stevenson MM,Keiser J,Geary TG

更新日期：2017-07-01 00:00:00