Antiplasmodial potential of selected medicinal plants from eastern Ghats of South India.

abstract：:Nematode parasites infect humans and domestic animals; treatment and prophylaxis require anthelmintic drugs because vaccination and sanitation is limited. Emodepside is a more recently introduced cyclooctadepsipeptide drug that has actions against GI nematodes, lungworm, and microfilaria. It has a novel mode of action...

journal_title：Experimental parasitology

authors： Martin RJ,Buxton SK,Neveu C,Charvet CL,Robertson AP

更新日期：2012-09-01 00:00:00

abstract：:Kinetoplastid organisms possess a unique organelle, the glycosome, which compartmentalizes the Embden-Meyerhof segment of glycolysis and several other metabolic pathways. In Trypanosoma brucei many of the enzyme activities localized to the glycosome are stage regulated. Two-dimensional gel analysis was used to examine...

journal_title：Experimental parasitology

authors： Parsons M,Nielsen B

更新日期：1990-04-01 00:00:00

abstract：:The excretory/secretory (ES) proteins of schistosomes play important roles in modulating host immune systems and are regarded as potential vaccine candidates and drug targets. Protein disulfide isomerase (PDI) is an essential enzyme that is involved in disulfide bond formation and rearrangement. In the present study, ...

journal_title：Experimental parasitology

authors： Cao X,Hong Y,Zhang M,Han Y,Wu M,Wang X,Guo X,Li C,Lu K,Li H,Fu Z,Lin J

更新日期：2014-11-01 00:00:00

abstract：:Resistance and sensitivity to normal human serum (NHS) of Trypanosoma congolense, a parasite believed to cause disease in animals only, were investigated in vivo as well as in vitro. Our results indicate that like Trypanosoma brucei, T. congolense can be grouped into three different phenotypes according to its resista...

journal_title：Experimental parasitology

authors： Xong HV,De Baetselier P,Pays E,Magez S

更新日期：2002-10-01 00:00:00

abstract：:Standard, immunocompetent, inbred strains of mice are non-permissive for infection with the human filarial nematode, Brugia malayi or the closely related Brugia pahangi. This non-permissiveness allows one to address the mechanism(s) that might be used by mammalian hosts to eliminate large, multicellular, metazoan, ext...

journal_title：Experimental parasitology

authors： Rajan TV,Ganley L,Paciorkowski N,Spencer L,Klei TR,Shultz LD

更新日期：2002-04-01 00:00:00

abstract：:Twenty-one Trypanosoma cruzi stocks isolated from Triatoma infestans and humans of the Chilean Andean highlands were studied at the genotypic level by schizodeme and molecular karyotype analyses, which allowed a clear distinction of the parasites from those hosts. A phenotypical characterization was performed by prote...

journal_title：Experimental parasitology

authors： Gonzalez J,Muñoz S,Ortiz S,Anacona D,Salgado S,Galleguillos M,Neira I,Sagua H,Solari A

更新日期：1995-08-01 00:00:00

abstract：:Differences in gene expression between adult and immature Fasciola hepatica (liver fluke) parasites isolated from the mammalian host were investigated using the technique of differential display. For any given primer combination used to produce these displays there were, on average, 22% apparently adult-specific and 1...

journal_title：Experimental parasitology

authors： Reed MB,Spithill TW,Strugnell RA,Panaccio M

更新日期：1998-06-01 00:00:00

abstract：:Only a few drugs are available for chemotherapy of African trypanosomiasis and there is an urgent need for the development of new anti-trypanosomal agents. In this study, the anti-helminthic drug niclosamide was tested for its trypanocidal activity in vitro using culture-adapted bloodstream forms of Trypanosoma brucei...

journal_title：Experimental parasitology

authors： Merschjohann K,Steverding D

更新日期：2008-04-01 00:00:00

abstract：:The expression and biological role of actin during the Trypanosoma cruzi life cycle remains largely unknown. Polyclonal antibodies against a recombinant T. cruzi actin protein were used to confirm its expression in epimastigotes, trypomastigotes, and amastigotes. Although the overall levels of expression were similar,...

journal_title：Experimental parasitology

authors： Cevallos AM,Segura-Kato YX,Merchant-Larios H,Manning-Cela R,Alberto Hernández-Osorio L,Márquez-Dueñas C,Ambrosio JR,Reynoso-Ducoing O,Hernández R

更新日期：2011-01-01 00:00:00

abstract：:Trypanosoma musculi is a hemoflagellate parasite producing a characteristic course of infection in the mouse, terminating in elimination of the parasite from the vascular system with permanent immunity to reinfection. While this elimination is known to require functional T lymphocytes, the role of these cells has rema...

journal_title：Experimental parasitology

authors： House RV,Dean JH

更新日期：1988-10-01 00:00:00

abstract：:The biochemical and morphological events which accompany lysis of Trypanosoma brucei by normal human serum have been described. The prelytic events include loss of infectivity and rapid cation shifts across the cell membrane. This is followed by cell swelling, fraying of the surface coat of the cell, loss of intracell...

journal_title：Experimental parasitology

authors： Rifkin MR

更新日期：1984-08-01 00:00:00

abstract：PURPOSE:Praziquantel (PZQ) is the conventional antibilharzial agent. Nevertheless, no antibilharzial prophylactic agents or 100% curable therapy approved and no reported data about use of human CD34+ Umbilical Cord Blood Stem Cells (CD34+UCBSCs) or Wharton Jelly Mesenchymal Stem Cells (WJMSCs) in prevention and/or comp...

journal_title：Experimental parasitology

authors： Magdy M,Fahmy A,Zaki NI,Mohamed AK

更新日期：2020-10-01 00:00:00

abstract：:In the present study, samples representing Orientobilharzia turkestanicum from cattle, sheep, cashmere goat and goat in Heilongjiang Province, China, were characterized and grouped genetically by sequences of internal transcribed spacer (ITS, including ITS-1 and ITS2) and 28S ribosomal DNA (28S rDNA). The ITS and 28S ...

journal_title：Experimental parasitology

authors： Wang CR,Li L,Ni HB,Zhai YQ,Chen AH,Chen J,Zhu XQ

更新日期：2009-02-01 00:00:00

abstract：:Tc-85, an 85-kDa surface glycoprotein specific for the trypomastigote stage of Trypanosoma cruzi, has been implicated in the invasion of host cells by the parasite. Radioactive palmitic acid was incorporated into Tc-85 immunoprecipitated from the culture medium with the H1A10 monoclonal antibody, suggesting that shedd...

journal_title：Experimental parasitology

authors： Abuin G,Couto AS,de Lederkremer RM,Casal OL,Galli C,Colli W,Alves MJ

更新日期：1996-04-01 00:00:00

abstract：:The swimming behavior of Poecilia vivipara was evaluated using an image analysis system comparing laboratory-reared uninfected fish before and after experimental infection with different intensities of cercariae of the trematode Acanthocollaritrema umbilicatum. Two experiments were performed, each with 30 fish which w...

journal_title：Experimental parasitology

authors： Santos EG,Cunha RA,Santos CP

更新日期：2011-02-01 00:00:00

abstract：:An NADP-linked glutamate dehydrogenase (EC 1.4.1.4) was found in the soluble fraction of Trichomonas vaginalis. Its molecular weight was about 230,000 (gel filtration). The enzyme, partially purified by diafiltration and hydroxyapatite column chromatography, was heat stable (1 hr at 57 C). It catalyzed both the aminat...

journal_title：Experimental parasitology

authors： Turner AC,Lushbaugh WB

更新日期：1988-10-01 00:00:00

abstract：:Resistance of human pathogens like Leishmania to drugs is a growing concern where the multidrug-resistant phenotype renders chemotherapy ineffective. The acquired resistance of Leishmania to antimony has promoted intense research on the mechanisms involved but the question has not been resolved yet. In this study we h...

journal_title：Experimental parasitology

authors： Singh N,Sundar S

更新日期：2017-05-01 00:00:00

abstract：:Aspartic proteases are important virulence factors for pathogens and are recognized as attractive drug targets. Seven aspartic proteases (ASPs) have been identified in Toxoplasma gondii genome. Bioinformatics and phylogenetic analyses regroup them into five monophyletic groups. Among them, TgASP1, a coccidian specific...

journal_title：Experimental parasitology

authors： Polonais V,Shea M,Soldati-Favre D

更新日期：2011-08-01 00:00:00

abstract：:Two species of glycoproteins from Leishmania braziliensis promastigotes of apparent molecular weights of 53,000 (glycoprotein 53) and 47,000 (glycoprotein 47) were localized. Four lectins with different sugar specificities bound to the blotting sheet to which the electrophoretically separated materials were transferre...

journal_title：Experimental parasitology

authors： Nagakura K,Tachibana H,Kaneda Y,Nakae T

更新日期：1986-06-01 00:00:00

abstract：:The oocysts of Eimeria tenella, one of the most pathogenic of several species causing chicken coccidiosis, are difficult to distinguish microscopically from several other infective Eimeria species. One copy of a gene coding for 5S ribosomal RNA has been cloned from E. tenella and sequenced. A coding region of 120 nucl...

journal_title：Experimental parasitology

authors： Stucki U,Braun R,Roditi I

更新日期：1993-02-01 00:00:00

abstract：:It is generally accepted that a majority of individuals infected by Entamoeba histolytica do not develop symptomatic disease. However, the parasite and the host factors contributing to the development of the disease, remain undetermined. It is also unclear why certain individuals develop extra-intestinal amebiasis wit...

journal_title：Experimental parasitology

authors： Simonishvili S,Tsanava S,Sanadze K,Chlikadze R,Miskalishvili A,Lomkatsi N,Imnadze P,Petri WA Jr,Trapaidze N

更新日期：2005-07-01 00:00:00

abstract：:Trypanosoma cruzi arginine kinase is a key enzyme in cell energy management and is also involved in pH and nutritional stress response mechanisms. T. cruzi epimastigotes treated with hydrogen peroxide presented a time-dependent increase in arginine kinase expression, up to 10-fold, when compared with untreated parasit...

journal_title：Experimental parasitology

authors： Miranda MR,Canepa GE,Bouvier LA,Pereira CA

更新日期：2006-12-01 00:00:00

abstract：:Interleukin-13 (IL-13) is a powerful anti-inflammatory cytokine that was previously shown to be a susceptibility factor for Leishmania major (L. major) infection. In this study we report a different role for IL-13 in rats infected with L. major; rIL-13 stimulates expression of pro-inflammatory cytokines and IL-12 whic...

journal_title：Experimental parasitology

authors： Haber ME,Daher CF,Karam MC,Baroody GM

更新日期：2009-03-01 00:00:00

abstract：:BmSI-7 and BmSI-6, two Boophilus microplus subtilisin inhibitors (BmSI) were purified and characterized from eggs. The inhibitors isolated by classical purification methods presented molecular masses of 7408 and 7271Da, respectively, by MALDI-TOF-MS. Both BmSI-7 and BmSI-6 inhibited neutrophil elastase (K(i) 0.4 and 0...

journal_title：Experimental parasitology

authors： Sasaki SD,de Lima CA,Lovato DV,Juliano MA,Torquato RJ,Tanaka AS

更新日期：2008-02-01 00:00:00

abstract：:Aedes aegypti mosquitoes salivate during intradermal probing of vertebrate prey before ingesting blood (Griffiths and Gordon 1952). Nonsalivating mosquitoes locate blood more slowly; this difference was ascribed to an anti-platelet activity found in the mosquito's saliva (Ribeiro et al. 1984). Mosquitoes infected with...

journal_title：Experimental parasitology

authors： Ribeiro JM,Rossignol PA,Spielman A

更新日期：1985-08-01 00:00:00

abstract：:A mode of action of the inducible treatment with trypsin for the development of Mesocestoides lineatus tetrathyridium to adult was analyzed by administering various agents effective on Ca2+-dependent metabolic pathways in the cells: protein kinase C activators such as a synthetic diacylglycerol, 1-oleoyl-2-acetylglyce...

journal_title：Experimental parasitology

authors： Kawamoto F,Fujioka H,Kumada N,Kojima K

更新日期：1986-12-01 00:00:00

abstract：:Nine of 18 chimpanzees inoculated with 250 infective third-stage larvae (L3) each developed patent (i.e., positive for microfilariae) Onchocerca volvulus infection. Four of 6 infected chimpanzees that received 200 micrograms/kg ivermectin at 28 days postinfection (pi) became patent, whereas, when ivermectin was given ...

journal_title：Experimental parasitology

authors： Soboslay PT,Weiss N,Dreweck CM,Taylor HR,Brotman B,Schulz-Key H,Greene BM

更新日期：1992-06-01 00:00:00

abstract：:Canine leishmaniosis due to Leishmania infantum is a widespread zoonotic disease. Although aminosidine can be an effective treatment, current therapeutic recommendations do not advocate its use, mainly due to concerns regarding the potential nephrotoxicity and ototoxicity of this drug. The aim of this randomized, blin...

journal_title：Experimental parasitology

authors： Kasabalis D,Chatzis MK,Apostolidis K,Xenoulis PG,Buono A,Petanides T,Leontides LS,Polizopoulou ZS,Steiner JM,Suchodolski JS,Saridomichelakis MN

更新日期：2019-11-01 00:00:00

abstract：:We probed DNA from all trypanosomatid genera by slot blot hybridization with an oligonucleotide (SL3') complementary to a sequence of the Phytomonas spliced-leader or mini-exon RNA. The 19-nucleotide probe target site was previously shown to be highly conserved among a limited number of Phytomonas isolates, but diverg...

journal_title：Experimental parasitology

authors： Teixeira MM,Serrano MG,Nunes LR,Campaner M,Buck GA,Camargo EP

更新日期：1996-12-01 00:00:00

abstract：:The aim of this study was to evaluate the effects of selenium and copper on oxidative stress and its performance in lambs experimentally infected with Haemonchus contortus. Twenty-eight five-months old lambs were experimentally infected by the oral route with 5000 third-stage infective larvae and allocated into four g...

journal_title：Experimental parasitology

authors： Leal ML,Pivoto FL,Fausto GC,Aires AR,Grando TH,Roos DH,Sudati JH,Wagner C,Costa MM,Molento MB,da Rocha JB

更新日期：2014-09-01 00:00:00