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In vitro trypanocidal activity of the anti-helminthic drug niclosamide.

Abstract：

:Only a few drugs are available for chemotherapy of African trypanosomiasis and there is an urgent need for the development of new anti-trypanosomal agents. In this study, the anti-helminthic drug niclosamide was tested for its trypanocidal activity in vitro using culture-adapted bloodstream forms of Trypanosoma brucei brucei and Trypanosoma congolense. The concentrations of niclosamide to reduce the growth rate by 50% and to kill all cells were in the low- and mid micromolar ranges for T. b. brucei and T. congolense, respectively. The very low toxicity of niclosamide for mammals makes the compound interesting for drug development for African trypanosomiasis.

journal_name

Exp Parasitol

journal_title

Experimental parasitology

authors

Merschjohann K,Steverding D

doi

10.1016/j.exppara.2007.12.001

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

637-40

issue

4

eissn

0014-4894

issn

1090-2449

pii

S0014-4894(07)00310-4

journal_volume

118

pub_type

杂志文章

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