Abstract:
:Extramedullar proliferation of eosinophil granulocytes can be induced in mice chronically infected with Schistosoma mansoni, by intraperitoneal implants of glass coverslips. Immature eosinophils are located in discrete foci on glass implants; they are not correlated with the eosinophil population of the peritoneal cavity, where only mature eosinophils can be observed. The same induction of eosinophil proliferation can be obtained in normal mice, by the transfer of macrophages elicited by glass implants in mice with chronic schistosomiasis. This induction could not be done with cells mobilized in normal mice, either after transplant into normal mice or into schistosome infected ones. Stimulated macrophages of mice with chronic schistosomiasis have a capacity to induce peripherical proliferation of eosinophil granulocytes. This capacity is independent of the quality of the intraperitoneal environment. It can be expressed after transferring macrophages elicited in schistosome infected mice into normal mice.
journal_name
Exp Parasitoljournal_title
Experimental parasitologyauthors
Borojevic R,Cury El-Cheikh MC,Nicola MHdoi
10.1016/0014-4894(86)90041-xsubject
Has Abstractpub_date
1986-12-01 00:00:00pages
349-55issue
3eissn
0014-4894issn
1090-2449journal_volume
62pub_type
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更新日期:2015-07-01 00:00:00
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