Abstract：
:Although macrophages have a microbicidal role in the immune system they themselves can be infected by pathogens. Often a simultaneous infection by more than one microbe may occur in a single cell. This is the first report of coinfection of macrophages with Toxoplasma gondii and Leishmania infantum, in vitro and in vivo. L. infantum does not cause severe disease in mice but T. gondii, RH strain, is lethal. Cell culture studies using THP-1 macrophages dually infected in vitro revealed that 4.3% harbored both parasites 24h after infection. When mice were infected with both parasites on the same day 7.3% of the infected cells carried both parasites 7 days later. Yet, if mice were first infected with L. infantum and then with Toxoplasma (5 days post-infection) 18.7% of the macrophages hosted either parasite but concomitant infection could not be found and mice, already harboring L. infantum, survived Toxoplasma's lethal effect.
journal_name
Exp Parasitoljournal_title
Experimental parasitologyauthors
Christodoulou V,Messaritakis I,Svirinaki E,Tsatsanis C,Antoniou Mdoi
10.1016/j.exppara.2011.02.022subject
Has Abstractpub_date
2011-07-01 00:00:00pages
279-84issue
3eissn
0014-4894issn
1090-2449pii
S0014-4894(11)00084-1journal_volume
128pub_type
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