当前位置： SCI文献检索 > EXPERIMENTAL PARASITOLOGY期刊下所有文献 > Effects of infection by larvae of Angiostrongylus cantonensis (Nematoda, Metastrongylidae) on the metabolism of the experimental intermediate host Biomphalaria glabrata.

Effects of infection by larvae of Angiostrongylus cantonensis (Nematoda, Metastrongylidae) on the metabolism of the experimental intermediate host Biomphalaria glabrata.

Abstract：

:The effect of infection by Angiostrongylus cantonensis on the activity of the enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and the concentration of total proteins, uric acid and urea in the hemolymph of Biomphalaria glabrata were investigated. The snails were dissected after 1, 2 and 3 weeks of infection to collect the hemolymph. The infection by A. cantonensis induced severe changes in the host snail's metabolism, triggering physiological mechanisms to minimize the deleterious effects caused by the larvae. There was a significant decrease in the concentration of total proteins in the infected snails, which occurred gradually as the infection advanced. This change was accompanied by an increase in the concentrations of urea and a decrease in the levels of uric acid in the hemolymph, suggesting that in this model the infection induces proteolysis and inversion of the excretion pattern of the infected snails. Besides this, variations in the activities of the aminotransferases were observed, with significantly higher levels in the infected groups than in the control group. These results indicate an increase in the protein metabolism of the infected snails, since there was an increase in nitrogen catabolites such as urea.

journal_name

Exp Parasitol

journal_title

Experimental parasitology

authors

Tunholi-Alves VM,Tunholi VM,Pinheiro J,Thiengo SC

doi

10.1016/j.exppara.2012.03.003

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

143-7

issue

2

eissn

0014-4894

issn

1090-2449

pii

S0014-4894(12)00085-9

journal_volume

131

pub_type

杂志文章

相关文献

EXPERIMENTAL PARASITOLOGY文献大全
  • Production of MMP-9 and inflammatory cytokines by Trypanosoma cruzi-infected macrophages.

    abstract：:Matrix metalloproteinases (MMPs) constitute a large family of Zn(2+) and Ca(2+) dependent endopeptidases implicated in tissue remodeling and chronic inflammation. MMPs also play key roles in the activation of growth factors, chemokines and cytokines produced by many cell types, including lymphocytes, granulocytes, and...

    journal_title：Experimental parasitology

    pub_type： 杂志文章

    doi：10.1016/j.exppara.2014.09.003

    authors： de Pinho RT,da Silva WS,de Castro Côrtes LM,da Silva Vasconcelos Sousa P,de Araujo Soares RO,Alves CR

    更新日期：2014-12-01 00:00:00

  • Acanthamoeba culbertsoni: analysis of amoebic adhesion and invasion on extracellular matrix components collagen I and laminin-1.

    abstract：:Acanthamoeba are free-living amoebae found in most environments that can cause brain and corneal infections. To infect humans, these pathogens must interact with host cells and the extracellular matrix (ECM). In order to define the mode by which amoebae recognize ECM components and process this recognition, we analyze...

    journal_title：Experimental parasitology

    pub_type： 杂志文章

    doi：10.1016/j.exppara.2009.08.004

    authors： Rocha-Azevedo Bd,Jamerson M,Cabral GA,Marciano-Cabral F

    更新日期：2010-09-01 00:00:00

  • Integrating genomics and proteomics permits identification of immunodominant antigens associated with drug resistance in human visceral leishmaniasis in India.

    abstract：:Resistance of human pathogens like Leishmania to drugs is a growing concern where the multidrug-resistant phenotype renders chemotherapy ineffective. The acquired resistance of Leishmania to antimony has promoted intense research on the mechanisms involved but the question has not been resolved yet. In this study we h...

    journal_title：Experimental parasitology

    pub_type： 杂志文章

    doi：10.1016/j.exppara.2017.02.019

    authors： Singh N,Sundar S

    更新日期：2017-05-01 00:00:00

  • Copper and selenium: auxiliary measure to control infection by Haemonchus contortus in lambs.

    abstract：:The aim of this study was to evaluate the effects of selenium and copper on oxidative stress and its performance in lambs experimentally infected with Haemonchus contortus. Twenty-eight five-months old lambs were experimentally infected by the oral route with 5000 third-stage infective larvae and allocated into four g...

    journal_title：Experimental parasitology

    pub_type： 杂志文章

    doi：10.1016/j.exppara.2014.06.005

    authors： Leal ML,Pivoto FL,Fausto GC,Aires AR,Grando TH,Roos DH,Sudati JH,Wagner C,Costa MM,Molento MB,da Rocha JB

    更新日期：2014-09-01 00:00:00

  • Echinococcus granulosus: cellular territories and morphological regions in mature protoscoleces.

    abstract：:Basic aspects of the generation, structure and function of Echinococcus granulosus protoscoleces are unknown. We review the work done on the structure and ultrastructure of the E. granulosus protoscolex and provide new data together with a comprehensive view of this form of the parasite. The surface, as observed by sc...

    journal_title：Experimental parasitology

    pub_type： 杂志文章

    doi：10.1016/j.exppara.2008.04.013

    authors： Galindo M,Schadebrodt G,Galanti N

    更新日期：2008-08-01 00:00:00

  • Crithidia guilhermei: gelatin- and haemoglobin-degrading extracellular metalloproteinases.

    abstract：:The extracellular metalloproteinases of the insect trypanosomatid Crithidia guilhermei were characterized through the incorporation of different protein substrates (gelatin, casein, haemoglobin, and bovine serum albumin) into SDS-PAGE. Two gelatinases (60 and 80 kDa) showed ability to degrade casein as well and a 67-k...

    journal_title：Experimental parasitology

    pub_type： 杂志文章

    doi：10.1016/s0014-4894(03)00037-7

    authors： de Melo AC,d'Avila-Levy CM,Branquinha MH,Vermelho AB

    更新日期：2002-11-01 00:00:00

  • Fasciola hepatica: stage-specific expression of novel gene sequences as identified by differential display.

    abstract：:Differences in gene expression between adult and immature Fasciola hepatica (liver fluke) parasites isolated from the mammalian host were investigated using the technique of differential display. For any given primer combination used to produce these displays there were, on average, 22% apparently adult-specific and 1...

    journal_title：Experimental parasitology

    pub_type： 杂志文章

    doi：10.1006/expr.1998.4287

    authors： Reed MB,Spithill TW,Strugnell RA,Panaccio M

    更新日期：1998-06-01 00:00:00

  • Pentamidine antagonizes the benznidazole's effect in vitro, and lacks of synergy in vivo: Implications about the polyamine transport as an anti-Trypanosoma cruzi target.

    abstract：:Benznidazole is the first-line drug used in treating Chagas disease, which is caused by the parasite Trypanosoma cruzi (T. cruzi). However, benznidazole has limited efficacy and several adverse reactions. Pentamidine is an antiprotozoal drug used in the treatment of leishmaniasis and African trypanosomiasis. In T. cru...

    journal_title：Experimental parasitology

    pub_type： 杂志文章

    doi：10.1016/j.exppara.2016.10.007

    authors： Seguel V,Castro L,Reigada C,Cortes L,Díaz MV,Miranda MR,Pereira CA,Lapier M,Campos-Estrada C,Morello A,Kemmerling U,Maya JD,López-Muñoz R

    更新日期：2016-12-01 00:00:00

  • In vitro trypanocidal activity of the anti-helminthic drug niclosamide.

    abstract：:Only a few drugs are available for chemotherapy of African trypanosomiasis and there is an urgent need for the development of new anti-trypanosomal agents. In this study, the anti-helminthic drug niclosamide was tested for its trypanocidal activity in vitro using culture-adapted bloodstream forms of Trypanosoma brucei...

    journal_title：Experimental parasitology

    pub_type： 杂志文章

    doi：10.1016/j.exppara.2007.12.001

    authors： Merschjohann K,Steverding D

    更新日期：2008-04-01 00:00:00

  • A sensitive method for assaying chemotaxic responses of Leishmania promastigotes.

    abstract：:This article describes a sensitive, cheap, and easy method for assaying chemotaxic responses of Leishmania promastigotes. A gradient of the substance to be assayed was produced inside a series of commercially available capillary tubes submerged in a promastigote suspension. After an incubation period, the attractivene...

    journal_title：Experimental parasitology

    pub_type： 杂志文章

    doi：10.1006/expr.2000.4569

    authors： Oliveira JS,Melo MN,Gontijo NF

    更新日期：2000-11-01 00:00:00

  • Optimized protocols for improving the likelihood of cloning recombinant progeny from Plasmodium yoelii genetic crosses.

    abstract：:Genetic cross is a powerful tool for studying malaria genes contributing to drug resistance, parasite development, and pathogenesis. Cloning and identification of recombinant progeny (RP) is laborious and expensive, especially when a large proportion of progeny derived from self-fertilization are present in the unclon...

    journal_title：Experimental parasitology

    pub_type： 杂志文章

    doi：10.1016/j.exppara.2012.10.011

    authors： Qi Y,Zhu F,Li J,Fu Y,Pattaradilokrat S,Hong L,Liu S,Huang F,Xu W,Su XZ

    更新日期：2013-01-01 00:00:00

  • Validation of cell-free culture using scanning electron microscopy (SEM) and gene expression studies.

    abstract：:A cell-free culture system for Cryptosporidium parvum was analysed using scanning electron microscopy (SEM) to characterise life cycle stages and compare gene expression in cell-free culture and cell culture using HCT-8 cells. Cryptosporidium parvum samples were harvested at 2 h, 8 h, 14 h, 26 h, 50 h, 74 h, 98 h, 122...

    journal_title：Experimental parasitology

    pub_type： 杂志文章

    doi：10.1016/j.exppara.2015.03.002

    authors： Yang R,Elankumaran Y,Hijjawi N,Ryan U

    更新日期：2015-06-01 00:00:00

  • Brugian infections in the peritoneal cavities of laboratory mice: kinetics of infection and cellular responses.

    abstract：:Standard, immunocompetent, inbred strains of mice are non-permissive for infection with the human filarial nematode, Brugia malayi or the closely related Brugia pahangi. This non-permissiveness allows one to address the mechanism(s) that might be used by mammalian hosts to eliminate large, multicellular, metazoan, ext...

    journal_title：Experimental parasitology

    pub_type： 杂志文章

    doi：10.1016/s0014-4894(02)00015-2

    authors： Rajan TV,Ganley L,Paciorkowski N,Spencer L,Klei TR,Shultz LD

    更新日期：2002-04-01 00:00:00

  • Standardization of DNA extraction from sand flies: Application to genotyping by next generation sequencing.

    abstract：:Standardization of the methods for extraction of DNA from sand flies is essential for obtaining high efficiency during subsequent molecular analyses, such as the new sequencing methods. Information obtained using these methods may contribute substantially to taxonomic, evolutionary, and eco-epidemiological studies. Th...

    journal_title：Experimental parasitology

    pub_type： 杂志文章

    doi：10.1016/j.exppara.2017.04.010

    authors： Casaril AE,de Oliveira LP,Alonso DP,de Oliveira EF,Gomes Barrios SP,de Oliveira Moura Infran J,Fernandes WS,Oshiro ET,Ferreira AMT,Ribolla PEM,de Oliveira AG

    更新日期：2017-06-01 00:00:00

  • Persistent production of inflammatory and anti-inflammatory cytokines and associated MHC and adhesion molecule expression at the site of infection and disease in experimental Trypanosoma cruzi infections.

    abstract：:Trypanosoma cruzi infection in humans and experimental animals often results in a chronic heart and gut inflammation and a dysfunction known as Chagas' disease. Previous studies have shown that the cellular infiltrate in the hearts of animals with chronic Chagas' disease consists mainly of CD8+ T cells. In this study,...

    journal_title：Experimental parasitology

    pub_type： 杂志文章

    doi：10.1006/expr.1996.0106

    authors： Zhang L,Tarleton RL

    更新日期：1996-11-01 00:00:00

  • Trypanosoma cruzi: Induction of benznidazole resistance in vivo and its modulation by in vitro culturing and mice infection.

    abstract：:Through a continuous in vivo drug pressure protocol, using mice as experimental model, we induced benznidazole resistance in Trypanosoma cruzi stocks. Full resistance was obtained for four out of five T. cruzi stocks analyzed. However, the number of benznidazole doses (40-180), as well as the time (4-18 months) necess...

    journal_title：Experimental parasitology

    pub_type： 杂志文章

    doi：10.1016/j.exppara.2008.09.007

    authors： Dos Santos FM,Caldas S,de Assis Cáu SB,Crepalde GP,de Lana M,Machado-Coelho GL,Veloso VM,Bahia MT

    更新日期：2008-12-01 00:00:00

  • Prodigiosin is not a determinant factor in lysis of Leishmania (Viannia) braziliensis after interaction with Serratia marcescens D-mannose sensitive fimbriae.

    abstract：:In this paper, the lytic activity of two variants of Serratia marcescens against promastigotes of Leishmania braziliensis was studied. In vitro assays showed that S. marcescens variant SM365 lyses L. braziliensis promastigotes, while the variant DB11 did not. Scanning electron microscopy (SEM) revealed that S. marcesc...

    journal_title：Experimental parasitology

    pub_type： 杂志文章

    doi：10.1016/j.exppara.2009.03.004

    authors： Moraes CS,Seabra SH,Albuquerque-Cunha JM,Castro DP,Genta FA,de Souza W,Brazil RP,Garcia ES,Azambuja P

    更新日期：2009-06-01 00:00:00

  • Trypanosoma cruzi: the Tc-85 surface glycoprotein shed by trypomastigotes bears a modified glycosylphosphatidylinositol anchor.

    abstract：:Tc-85, an 85-kDa surface glycoprotein specific for the trypomastigote stage of Trypanosoma cruzi, has been implicated in the invasion of host cells by the parasite. Radioactive palmitic acid was incorporated into Tc-85 immunoprecipitated from the culture medium with the H1A10 monoclonal antibody, suggesting that shedd...

    journal_title：Experimental parasitology

    pub_type： 杂志文章

    doi：10.1006/expr.1996.0036

    authors： Abuin G,Couto AS,de Lederkremer RM,Casal OL,Galli C,Colli W,Alves MJ

    更新日期：1996-04-01 00:00:00

  • The potential therapeutic effect of adipose-derived mesenchymal stem cells in the treatment of cutaneous leishmaniasis caused by L. major in BALB/c mice.

    abstract：:Leishmaniasis is one of the most neglected tropical infectious diseases in the world. The emergence of drug resistance and toxicity and the high cost of the available drugs with a lack of new anti-leishmanial drugs highlight the need to search for newer therapies with anti-leishmanial activities. Due to the mesenchyma...

    journal_title：Experimental parasitology

    pub_type： 杂志文章

    doi：10.1016/j.exppara.2020.108063

    authors： Bahrami S,Safari M,Razi Jalali MH,Ghorbanpoor M,Tabandeh MR,Rezaie A

    更新日期：2021-01-04 00:00:00

  • Leishmania sp: comparative study with Toxoplasma gondii and Trypanosoma cruzi in their ability to initialize IL-12 and IFN-gamma synthesis.

    abstract：:We compared in vitro and in vivo induction of IL-12 (p40) and IFN-gamma by mouse cells stimulated with Toxoplasma gondii, Trypanosoma cruzi, and different species of Leishmania. Spleen cells cultured in vitro with T. cruzi or T. gondii, but not with Leishmania, produced IL-12 (p40) and IFN-gamma. Accordingly, IL-12 (p...

    journal_title：Experimental parasitology

    pub_type： 杂志文章

    doi：10.1006/expr.2000.4523

    authors： Oliveira MA,Santiago HC,Lisboa CR,Ceravollo IP,Trinchieri G,Gazzinelli RT,Vieira LQ

    更新日期：2000-06-01 00:00:00

  • Toxicity effect of the acaricide fipronil in semi-engorged females of the tick Rhipicephalus sanguineus (Latreille, 1806) (Acari: Ixodidae): preliminary determination of the minimum lethal concentration and LC(50).

    abstract：:Chemical acaricides, especially fipronil (active ingredient of Frontline®), are still the most effective method to control tick populations. In this study, the effectiveness of fipronil was assessed in semi-engorged females of the tick Rhipicephalus sanguineus. A protocol for an in vitro bioassay (AIT) was developed, ...

    journal_title：Experimental parasitology

    pub_type： 杂志文章

    doi：10.1016/j.exppara.2010.09.009

    authors： de Oliveira PR,Bechara GH,Denardi SE,Pizano MA,Mathias MI

    更新日期：2011-02-01 00:00:00

  • Non-classic characteristics define prominent DNase activities from the intestine and other tissues of Haemonchus contortus.

    abstract：:The anthelmintic fenbendazole (FBZ) induces nuclear DNA fragmentation (DF) in intestinal cells of Haemonchus contortus. The DNA fragments had 3'-OH, which suggests involvement of a neutral DNase. To identify candidate DNase(s) involved, DNase activity in H. contortus intestine and other worm fractions was characterize...

    journal_title：Experimental parasitology

    pub_type： 杂志文章

    doi：10.1016/s0014-4894(03)00136-x

    authors： Kwak D,Jasmer DP

    更新日期：2003-07-01 00:00:00

  • Expression, immunolocalization and serodiagnostic value of a myophilin-like protein from Schistosoma japonicum.

    abstract：:The cDNA of a Schistosoma japonicum myophilin-like protein was cloned, sequenced, and expressed in Escherichia coli as a recombined protein (rSj myophilin-like protein), and the protein was purified by affinity chromatography. The deduced amino acid sequences of the Sj myophilin-like protein showed significant homolog...

    journal_title：Experimental parasitology

    pub_type： 杂志文章

    doi：10.1016/j.exppara.2008.01.017

    authors： Peng H,Song K,Huang C,Ye S,Song H,Hu W,Han Z,McManus DP,Zhao G,Zhang Q

    更新日期：2008-05-01 00:00:00

  • Screening and characterization of apical membrane antigen 1 interacting proteins in Eimeria tenella.

    abstract：:Avian coccidiosis is a widespread and economically significant disease of poultry. It is an enteric disease caused by several protozoan Eimeria species. Eimeria belongs to the phylum Apicomplexa, which exhibits an unusual mechanism of host cell invasion. During invasion of host cells, the protein apical membrane antig...

    journal_title：Experimental parasitology

    pub_type： 杂志文章

    doi：10.1016/j.exppara.2016.09.014

    authors： Han H,Xue P,Dong H,Zhu S,Zhao Q,Huang B

    更新日期：2016-11-01 00:00:00

  • Glucose-6-phosphate dehydrogenase from Plasmodium berghei: kinetic and electrophoretic characterization.

    abstract：:Evidence is given for the existence of a parasite-specific glucose-6-phosphate dehydrogenase (G6PD) in Plasmodium berghei by characterization of its kinetic and electrophoretic properties. From infected rat erythrocytes the parasites were isolated, washed, and lysed. G6PD was purified by affinity chromatography with 2...

    journal_title：Experimental parasitology

    pub_type： 杂志文章

    doi：10.1016/0014-4894(90)90108-o

    authors： Buckwitz D,Jacobasch G,Kuckelkorn U,Plonka A,Gerth C

    更新日期：1990-04-01 00:00:00

  • Plasmodium falciparum: asparagine mutant at residue 108 of dihydrofolate reductase is an optimal antifolate-resistant single mutant.

    abstract：:The codon for serine residue 108 of the Plasmodium falciparum dihydrofolate reductase gene was replaced with those for the other 19 amino acids. Except for the Lys108 mutant, which was not expressed, all other substitutions yielded DHFR mutants which were expressed in Escherichia coli as inactive inclusion bodies. Nin...

    journal_title：Experimental parasitology

    pub_type： 杂志文章

    doi：10.1006/expr.1997.4221

    authors： Sirawaraporn W,Yongkiettrakul S,Sirawaraporn R,Yuthavong Y,Santi DV

    更新日期：1997-11-01 00:00:00

  • A molecular tool for species identification and benzimidazole resistance diagnosis in larval communities of small ruminant parasites.

    abstract：:This report describes a molecular method for determining in a first step the generic composition of a nematode community and in a second step, the resistance of each species to benzimidazole (BZ). We first established a polymerase chain reaction (PCR) linked to a restriction fragment length polymorphism strategy using...

    journal_title：Experimental parasitology

    pub_type： 杂志文章

    doi：10.1006/expr.2000.4542

    authors： Silvestre A,Humbert JF

    更新日期：2000-08-01 00:00:00

  • Toxoplasma gondii antigens: recovery analysis of tachyzoites cultivated in Vero cell maintained in serum free medium.

    abstract：:Vero cells have been used successfully in Toxoplasma gondii maintenance. Medium supplementation for culture cells with fetal bovine serum is necessary for cellular growth. However, serum in these cultures presents disadvantages, such as the potential to induce hypersensitivity, variability of serum batches, possible p...

    journal_title：Experimental parasitology

    pub_type： 杂志文章

    doi：10.1016/j.exppara.2012.01.005

    authors： da Costa-Silva TA,da Silva Meira C,Frazzatti-Gallina N,Pereira-Chioccola VL

    更新日期：2012-04-01 00:00:00

  • Identification and characterization of a Giardia lamblia group-specific gene.

    abstract：:Giardia lamblia consist of heterogeneous isolates that can be divided into at least three groups. Differential screening of a cDNA library with isolate-specific antisera identified a gene which is expressed and found only in Group 3 isolates. This gene, GLORF-C4, is 597 bp in length and predicts a deduced protein of 1...

    journal_title：Experimental parasitology

    pub_type： 杂志文章

    doi：10.1016/0014-4894(92)90250-e

    authors： Nash TE,Mowatt MR

    更新日期：1992-12-01 00:00:00

  • Comparative study of different forms of Jellein antimicrobial peptide on Leishmania parasite.

    abstract：:Typically, antimicrobial peptides (AMPs) are short positive charged peptides serving a key role in innate immunity as well as antimicrobial activity. Discovering novel therapeutic agents is considered as an undeniable demand due to increasing microbial species with antibiotic resistance. In this direction, the unique ...

    journal_title：Experimental parasitology

    pub_type： 杂志文章

    doi：10.1016/j.exppara.2019.107823

    authors： Zahedifard F,Lee H,No JH,Salimi M,Seyed N,Asoodeh A,Rafati S

    更新日期：2020-02-01 00:00:00