Abstract：
:The aim of this study was to evaluate the effects of selenium and copper on oxidative stress and its performance in lambs experimentally infected with Haemonchus contortus. Twenty-eight five-months old lambs were experimentally infected by the oral route with 5000 third-stage infective larvae and allocated into four groups, i.e., untreated animals, animals treated intramuscularly with sodium selenite (0.2 mg kg(-1)), animals treated subcutaneously with copper (3.5 mg kg(-1)), and animals treated with sodium selenite (IM; 0.2 mg kg(-1)) and copper (SC; 3.5 mg kg(-1)). These animals received oat hay (Avena sativa) and commercial concentrate, totaling 15% of crude protein, 30% being derived from oat hay and 70% of the concentrate. Lipid peroxidation, antioxidant enzymes, eggs per gram of feces (EPG) and body weight were assessed on the day of infection and after 20, 40, 60 and 80 days post-infection. The number of H. contortus adults was assessed at the end of the experiment. The selenium associated or not with copper reduced the effects of oxidative stress caused by infection. The groups supplemented with copper had increased body weight, and the combination of these two minerals reduced the EPG and number of H. contortus adults in lambs. The use of selenium associated with copper may help the control of infection by H. contortus.
journal_name
Exp Parasitoljournal_title
Experimental parasitologyauthors
Leal ML,Pivoto FL,Fausto GC,Aires AR,Grando TH,Roos DH,Sudati JH,Wagner C,Costa MM,Molento MB,da Rocha JBdoi
10.1016/j.exppara.2014.06.005subject
Has Abstractpub_date
2014-09-01 00:00:00pages
39-43eissn
0014-4894issn
1090-2449pii
S0014-4894(14)00143-Xjournal_volume
144pub_type
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