Abstract：
:Schistosomiasis is one of the world's greatly neglected tropical diseases, and its control is largely dependent on a single drug, praziquantel. Here, we report the in vitro effect of piplartine, an amide isolated from Piper tuberculatum (Piperaceae), on Schistosoma mansoni adult worms. A piplartine concentration of 15.8 μM reduced the motor activity of worms and caused their death within 24h in a RPMI 1640 medium. Similarly, the highest sub-lethal concentration of piplartine (6.3 μM) caused a 75% reduction in egg production in spite of coupling. Additionally, piplartine induced morphological changes on the tegument, and a quantitative analysis carried out by confocal microscopy revealed an extensive tegumental destruction and damage in the tubercles. This damage was dose-dependent in the range of 15.8-630.2 μM. At doses higher than 157.6 μM, piplartine induced morphological changes in the oral and ventral sucker regions of the worms. It is the first time that the schistosomicidal activity has been reported for piplartine.
journal_name
Exp Parasitoljournal_title
Experimental parasitologyauthors
Moraes Jd,Nascimento C,Lopes PO,Nakano E,Yamaguchi LF,Kato MJ,Kawano Tdoi
10.1016/j.exppara.2010.08.021subject
Has Abstractpub_date
2011-02-01 00:00:00pages
357-64issue
2eissn
0014-4894issn
1090-2449pii
S0014-4894(10)00309-7journal_volume
127pub_type
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