Trypanosoma cruzi: Oxidative stress induces arginine kinase expression.

Abstract:

:Trypanosoma cruzi arginine kinase is a key enzyme in cell energy management and is also involved in pH and nutritional stress response mechanisms. T. cruzi epimastigotes treated with hydrogen peroxide presented a time-dependent increase in arginine kinase expression, up to 10-fold, when compared with untreated parasites. Among other oxidative stress-generating compounds tested, only nifurtimox produced more than 2-fold increase in arginine kinase expression. Moreover, parasites overexpressing arginine kinase showed significantly increased survival capability during hydrogen peroxide exposure. These findings suggest the participation of arginine kinase in oxidative stress response systems.

journal_name

Exp Parasitol

authors

Miranda MR,Canepa GE,Bouvier LA,Pereira CA

doi

10.1016/j.exppara.2006.04.004

subject

Has Abstract

pub_date

2006-12-01 00:00:00

pages

341-4

issue

4

eissn

0014-4894

issn

1090-2449

pii

S0014-4894(06)00099-3

journal_volume

114

pub_type

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