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Leishmania donovani: purification and partial characterization of a glycophosphosphingolipid antigen expressed on promastigote surface.

Abstract：

:A ceramide-anchored glycophosphosphingolipid antigen was isolated from the lipid extract of Leishmania donovani promastigotes. The affinity-purified glycolipid antigen contained galactose, mannose, myo-inositol, phosphate, ceramide, and hexosamine but no sialic acid. The phosphate group was present internally at the core of the structure: inositol (1-O)-phosphorylceramide. The phosphate group became susceptible to alkaline phosphatase only after alkali-catalyzed hydrolysis of the glycolipid.

journal_name

Exp Parasitol

journal_title

Experimental parasitology

authors

De-Majumdar T

doi

10.1016/0014-4894(92)90148-4

keywords:

subject

Has Abstract

pub_date

1992-05-01 00:00:00

pages

251-60

issue

3

eissn

0014-4894

issn

1090-2449

pii

0014-4894(92)90148-4

journal_volume

74

pub_type

杂志文章

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