Abstract:
:The development of nanotechnology has generated new means of disease diagnosis and treatment. Infectious diseases, including leishmaniasis, malaria, etc., have benefited from the advent of new nanomaterials and/or nanodevices capable of detecting specific antigens and antibodies with high specificity and low cost. In this paper, we present an investigation on a single-celled protozoan Leishmaniasis parasite, a disease considered of standard infectivity, given the high degree of immunological specificity. Natural rubber (NR) membranes incorporating gold nanoparticles (GNPs) were placed in the culture medium and the physiological behavior of Leishmania brasiliensis promastigotes was evaluated. The natural rubber membranes containing GNPs decreased the population growth rate, showing a lower index of living promastigotes (attached to the membrane surface) depending on the amount of nanoparticles deposited in the membrane surface. Such membranes may be used to develop a flexible band-aid for skin lesions from degenerative infection state, inhibiting the population growth of parasites in the lesions. In addition, natural rubber membranes would also stimulate angiogenesis in damaged tissues.
journal_name
Exp Parasitoljournal_title
Experimental parasitologyauthors
Barboza-Filho CG,Cabrera FC,Dos Santos RJ,De Saja Saez JA,Job AEdoi
10.1016/j.exppara.2011.10.015subject
Has Abstractpub_date
2012-02-01 00:00:00pages
152-8issue
2eissn
0014-4894issn
1090-2449pii
S0014-4894(11)00327-4journal_volume
130pub_type
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