Synthesis, antimalarial activity and molecular docking of hybrid 4-aminoquinoline-1,3,5-triazine derivatives.

abstract：:In the intestinal tract of fifth instars of the hematophagous reduviid bugs Rhodnius prolixus and Triatoma infestans blood ingestion induced an initial decrease of the concentration of the respective symbiotic bacteria Rhodococcus rhodnii and Nocardia sp. and then within 10 days a 15- or 18-fold increase of the total ...

journal_title：Experimental parasitology

authors： Eichler S,Schaub GA

更新日期：2002-01-01 00:00:00

abstract：:This study examines the effects of ricinoleic acid esters from Ricinus communis castor oil on the vitellogenesis of Rhipicephalus sanguineus ticks attached to hosts that were fed with commercial rabbit food containing these esters. The oocytes of ticks from the treatment group (TG) showed cytoplasmic changes that inhi...

journal_title：Experimental parasitology

authors： Arnosti A,Brienza PD,Furquim KC,Chierice GO,Bechara GH,Calligaris IB,Camargo-Mathias MI

更新日期：2011-02-01 00:00:00

abstract：:In C57BL/6 mice, Leishmania donovani infection in the liver provoked IFN-γ-induced expression of the immunity-related GTPases (IRG), Irgm1 and Irgm3. To gauge the antileishmanial effects of these macrophage factors in the liver, intracellular infection was analyzed in IRG-deficient mice. In early- (but not late-) stag...

journal_title：Experimental parasitology

authors： Murray HW,Mitchell-Flack M,Taylor GA,Ma X

更新日期：2015-10-01 00:00:00

abstract：:In this work CD4-knockout mice were used as a model to analyse the role of CD4+ T cells in the antibody response against Echinococcus granulosus immunization or experimental infection. Results obtained with mice immunized with protoscolex antigens indicated that these contain T-independent antigens. After infection, C...

journal_title：Experimental parasitology

authors： Baz A,Carol H,Fernández V,Mourglia-Ettlin G,Nieto A,Orn A,Dematteis S

更新日期：2008-08-01 00:00:00

abstract：:Few studies have investigated Toxoplasma gondii infections in bat populations and none have reported its presence in protected British bat species. Using a collection of dead/euthanased bats collected from Lancashire, UK, two species of bats (Pipistrellus pipistrellus and Pipistrellus pygmaeus) were tested using a hig...

journal_title：Experimental parasitology

authors： Dodd NS,Lord JS,Jehle R,Parker S,Parker F,Brooks DR,Hide G

更新日期：2014-04-01 00:00:00

abstract：:About 200 clinically used amphiphilic cationic drugs have been shown to be active in vitro against Trypanosoma cruzi at concentrations of less than or equal to 1 mM. Activity against epimastigote and trypomastigote forms was similar, and in both cases the most potent drugs were litracene, maprotiline, thioproperazine,...

journal_title：Experimental parasitology

authors： Hammond DJ,Hogg J,Gutteridge WE

更新日期：1985-08-01 00:00:00

abstract：:A genetically homogeneous population of Plasmodium falciparum prepared by a single erythrocyte micromanipulation technique was used to produce lines of P. falciparum resistant to mefloquine hydrochloride in vitro. Parasites were maintained in a culture medium containing gradually increased concentrations of mefloquine...

journal_title：Experimental parasitology

authors： Oduola AM,Milhous WK,Weatherly NF,Bowdre JH,Desjardins RE

更新日期：1988-12-01 00:00:00

abstract：:The pathogenesis of chronic schistosomiasis is caused by irritation of the schistosome eggs trapped in liver that induce delayed hypersensitive reactions from the surrounding tissues, leading to the formation of inflammatory granuloma and subsequent fibrosis. A Schistosoma japonicum (S. japonicum) single-chain fragmen...

journal_title：Experimental parasitology

authors： Tian Z,Wang XY,Zhou YF,Feng QM,Zhang SJ,Yin TQ,Xu SR,Xia YD,Xu J,Jin J,Wang SP

更新日期：2013-08-01 00:00:00

abstract：:The present study was to determine the efficacies of anti-parasitic activities of synthesized silver nanoparticles (Ag NPs) using stem aqueous extract of Cissus quadrangularis against the adult of hematophagous fly, Hippobosca maculata (Diptera: Hippoboscidae), and the larvae of cattle tick, Rhipicephalus (Boophilus) ...

journal_title：Experimental parasitology

authors： Santhoshkumar T,Rahuman AA,Bagavan A,Marimuthu S,Jayaseelan C,Kirthi AV,Kamaraj C,Rajakumar G,Zahir AA,Elango G,Velayutham K,Iyappan M,Siva C,Karthik L,Rao KV

更新日期：2012-10-01 00:00:00

abstract：:Galactokinase catalyses the ATP-dependent phosphorylation of galactose. A galactokinase-like sequence was identified in a Fasciola hepatica EST library. Recombinant expression of the corresponding protein in Escherichia coli resulted in a protein of approximately 50 kDa. The protein is monomeric, like galactokinases f...

journal_title：Experimental parasitology

authors： Zinsser VL,Cox C,McAuley M,Hoey EM,Trudgett A,Timson DJ

更新日期：2018-09-01 00:00:00

abstract：:At least eight protein members of HSP70 and three of the HSP60 families have been identified in Trypanosoma cruzi; of these, five HSP70 isoforms and one HSP60 isoform were respectively induced by a 2-hr heat-shock treatment at 37 degrees C. Immunoelectronmicroscopy of epimastigote, spheromastigote, and metacyclic cell...

journal_title：Experimental parasitology

authors： Giambiagi-deMarval M,Souto-Padrón T,Rondinelli E

更新日期：1996-08-01 00:00:00

abstract：:Rosetting is a parasite adhesion phenotype associated with severe malaria in African children. Why parasites form rosettes is unknown, although enhanced invasion or immune evasion have been suggested as possible functions. Previous work showed that rosetting does not enhance parasite invasion under standard in vitro c...

journal_title：Experimental parasitology

authors： Deans AM,Rowe JA

更新日期：2006-04-01 00:00:00

abstract：:Allelic variation in the Plasmodium falciparum merozoite surface protein 1 (MSP1) gene is expressed as an association of allelic types in variable blocks. In this study, a PCR strategy that can detect 24 different MSP1 association types was used to investigate allelic variation in the MSP1 gene. We identified 236 dist...

journal_title：Experimental parasitology

authors： Kaneko O,Kimura M,Kawamoto F,Ferreira MU,Tanabe K

更新日期：1997-05-01 00:00:00

abstract：:The cDNA clone coding a major vault protein (MVP)-like protein was derived from Echinococcus multilocularis cysts. MVP is a main component of vault particles, which are the largest cytoplasmic ribonucleoprotein particles in eukaryotic cells. We sequenced and characterized E. multilocularis MVP (EmMVP). The nucleotide ...

journal_title：Experimental parasitology

authors： Goto A,Kouguchi H,Yamano K,Sawada Y

更新日期：2013-05-01 00:00:00

abstract：:The Gal/GalNAc lectin gene of Entamoeba histolytica is a major amebic virulence protein responsible for interaction with host tissues. We investigated sequence differences in the Gal/GalNAc lectin heavy subunit in three isolates from Bangladesh and one isolate from Georgia, each of which was determined to be genetical...

journal_title：Experimental parasitology

authors： Beck DL,Tanyuksel M,Mackey AJ,Haque R,Trapaidze N,Pearson WR,Loftus B,Petri WA

更新日期：2002-06-01 00:00:00

abstract：:Because traditional methods used for sewage sludge parasitological examinations have low sensitivity, a new, highly effective method (own method - OM) was devised. The principle of this method is to eliminate the flocculent effect on the structure of sewage sludge by mechanically damaging floccules in the presence of ...

journal_title：Experimental parasitology

authors： Zdybel J,Karamon J,Różycki M,Bilska-Zając E,Kłapeć T,Cencek T

更新日期：2016-11-01 00:00:00

abstract：:A polymerase chain reaction (PCR-based) assay was evaluated for detection of Trypanosoma evansi DNA in experimentally infected mice and naturally infected camels, sheep and goats using the set of primers TBr(1) & TBr(2) that amplified 164 bp DNA fragment. The results revealed that PCR-based assay was able to detect T....

journal_title：Experimental parasitology

authors： Ashour AA,Abou El-Naga TR,Barghash SM,Salama MS

更新日期：2013-05-01 00:00:00

abstract：:Snails from a B. glabrata stock, selected for nonsusceptibility to the NMRI strain of S. mansoni, exhibited unusual schistosome infections, with multiple sporocysts prominent in the head-foot (foot-sporocysts). When F1 progeny from numerous crosses between well-defined susceptible (S) and resistant (R) parental snails...

journal_title：Experimental parasitology

authors： Lewis FA,Richards CS,Knight M,Cooper LA,Clark B

更新日期：1993-11-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Experimental parasitology

authors： He GZ

更新日期：2012-04-11 00:00:00

abstract：:Hemocytes derived from a strain (13-16-R1) of Biomphalaria glabrata resistant to Schistosoma mansoni were significantly more likely to bind untreated latex beads than hemocytes from the schistosome-susceptible M line strain. Beads preincubated in 13-16-R1 plasma were more readily bound by both 13-16-R1 and M line hemo...

journal_title：Experimental parasitology

authors： Uchikawa R,Loker ES

更新日期：1992-09-01 00:00:00

abstract：:Chemotherapy of food-borne trematodes relies on two drugs, praziquantel and tricabendazole, and there is growing interest in finding alternative therapies. Plant oil extracts have long been used in traditional Chinese medicine as sources of bioactive compounds with antiparasitic activity. Species of the genus Echinost...

journal_title：Experimental parasitology

authors： Souza JG,Lopes Torres EJ,Garcia JS,Gomes AP,Rodrigues-Silva R,Maldonado A Jr,Machado-Silva JR

更新日期：2017-03-01 00:00:00

abstract：:Monoclonal antibodies (mAb) directed against Schistosoma mansoni tropomyosin isoform, SMTM (Xu et al. Experimental Parasitology 69, 373-392, 1989), were used to test for cross-reactivity with Biomphalaria glabrata antigens. One mAb (1F10) recognized antigens of 39, 41, and 80 kDa in a snail head/foot antigen preparati...

journal_title：Experimental parasitology

authors： Weston D,Allen B,Thakur A,LoVerde PT,Kemp WM

更新日期：1994-05-01 00:00:00

abstract：:We have identified congenic mouse strains that differ dramatically in resistance to infection with the murine malaria parasite Plasmodium yoelii 17X. After infection, BALB/c mice develop severe anemia and a high degree of parasitemia which sometimes results in death. The mtv-7 congenic strain BALB.D2.mlsa, however, de...

journal_title：Experimental parasitology

authors： Swardson CJ,Wassom DL,Avery AC

更新日期：1997-06-01 00:00:00

abstract：:Cystic echinococcosis (CE) is caused by the larval stage of Echinococcus granulosus, which in this disease the metacestode develop in visceral organs especially liver and lungs. The disease is present worldwide and affects humans as well as herbivores including cattle, sheep, camels, horses and others. Benzimidazole c...

journal_title：Experimental parasitology

authors： Ahmadnia S,Moazeni M,Mohammadi-Samani S,Oryan A

更新日期：2013-10-01 00:00:00

abstract：:The intraerythrocytic malaria parasite digests haemoglobin to provide amino acids for metabolism and releases toxic haem that is sequestered into haemozoin, a non-toxic, insoluble, crystalline pigment. Following erythrocyte rupture, haemozoin is released into circulation and phagocytosed by monocytes. Phagocytosed hae...

journal_title：Experimental parasitology

authors： Cumming BM,Goldring JPD

更新日期：2019-02-01 00:00:00

abstract：:Non-invasive small animal in vivo imaging is an essential tool in a broad variety of biomedical sciences and enables continuous monitoring of disease progression in order to develop and improve diagnostic, therapeutic and preventive measures. Imaging parasites non-invasively in live animals allows efficient parasite d...

journal_title：Experimental parasitology

authors： Novobilský A,Höglund J

更新日期：2020-07-01 00:00:00

abstract：:Plasmodium vivax is the predominant species of the human malaria parasite present in the Indian subcontinent. There have been recent reports on Chloroquine (CQ) resistance and severe manifestations shown by P. vivax from different regions of the world including India. This study focuses on Bikaner, India where during ...

journal_title：Experimental parasitology

authors： Garg S,Saxena V,Lumb V,Pakalapati D,Boopathi PA,Subudhi AK,Chowdhury S,Kochar SK,Kochar DK,Sharma YD,Das A

更新日期：2012-12-01 00:00:00

abstract：:In vitro anthelmintic activity of crude extracts of the ripe fruits of Hedera helix was investigated on eggs and adult nematode parasites Haemonchus contortus. Aqueous extract of H. helix was also evaluated for in vivo anthelmintic activity at dose of 1.13 and 2.25 g/kg in sheep artificially infected with H. contortus...

journal_title：Experimental parasitology

authors： Eguale T,Tilahun G,Debella A,Feleke A,Makonnen E

更新日期：2007-08-01 00:00:00

abstract：:The burden of Plasmodium vivax malaria is huge in India, affecting a large population annually. Recent reports of P. vivax contributing to severe illness and death, makes vaccine research on P. vivax malaria, a high priority. Extent of sequence variation in antigen coding genes is known to be a major hurdle in vaccine...

journal_title：Experimental parasitology

authors： Rahul CN,Shiva Krishna K,Meera Bai N,Kumar V,Phadke S,Rajesh V

更新日期：2013-05-01 00:00:00

abstract：:Using [(3)H]inulin uptake as a measure of pharyngeal pumping activity, we have investigated and compared the effects of glutamate, ivermectin, and moxidectin on inulin uptake in susceptible and ivermectin-selected Haemonchus contortus. Inulin uptake is inhibited by glutamate, ivermectin, and moxidectin, at biologicall...

journal_title：Experimental parasitology

authors： Paiement JP,Leger C,Ribeiro P,Prichard RK

更新日期：1999-07-01 00:00:00