当前位置： SCI文献检索 > EXPERIMENTAL PARASITOLOGY期刊下所有文献 > IFN-γ-induced macrophage antileishmanial mechanisms in mice: A role for immunity-related GTPases, Irgm1 and Irgm3, in Leishmania donovani infection in the liver.

IFN-γ-induced macrophage antileishmanial mechanisms in mice: A role for immunity-related GTPases, Irgm1 and Irgm3, in Leishmania donovani infection in the liver.

Abstract：

:In C57BL/6 mice, Leishmania donovani infection in the liver provoked IFN-γ-induced expression of the immunity-related GTPases (IRG), Irgm1 and Irgm3. To gauge the antileishmanial effects of these macrophage factors in the liver, intracellular infection was analyzed in IRG-deficient mice. In early- (but not late-) stage infection, Irgm3(-/-) mice failed to properly control parasite replication, generated little tissue inflammation and were hyporesponsive to pentavalent antimony (Sb) chemotherapy. Observations limited to early-stage infection in Irgm1(-/-) mice demonstrated increased susceptibility and virtually no inflammatory cell recruitment to heavily-parasitized parenchymal foci but an intact response to chemotherapy. In L. donovani infection in the liver, the absence of either Irgm1 or Irgm3 impairs early inflammation and initial resistance; the absence of Irgm3, but not Irgm1, also appears to impair the intracellular efficacy of Sb chemotherapy.

journal_name

Exp Parasitol

journal_title

Experimental parasitology

authors

Murray HW,Mitchell-Flack M,Taylor GA,Ma X

doi

10.1016/j.exppara.2015.07.005

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

103-9

eissn

0014-4894

issn

1090-2449

pii

S0014-4894(15)30011-4

journal_volume

157

pub_type

杂志文章

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