Abstract:
:Chagas disease is characterized by cardiac lesions and a high level of PGE2. Our objective was to investigate the role of PGE2 in cardiac lesions. BALB/c mice were infected with Trypanosoma cruzi (1x10(3) trypomastigote forms) and were treated daily with PBS, meloxicam (0.5 mg/kg) or etoricoxib (0.6 mg/kg). The animals were sacrificed on the 21st day of infection and we collected the cardiac tissue and spleen cells for tissue culture. We observed that treatment with COX-2 inhibitors was able to decrease synthesis of PGE2 by spleen cells. This reduction was accompanied by reduction of the inflammatory infiltrate, parasite nets, cardiac fibrosis and fewer COX-2 positive cells in cardiac tissue obtained from these animals. In conclusion, treatment with COX-2 inhibitors, and consequent inhibition of PGE2 synthesis, was able to reduce the cardiac damage observed during the acute phase of experimental Chagas disease, thus demonstrating the involvement of this mediator in the cardiac lesion.
journal_name
Exp Parasitoljournal_title
Experimental parasitologyauthors
Abdalla GK,Faria GE,Silva KT,Castro EC,Reis MA,Michelin MAdoi
10.1016/j.exppara.2007.11.003subject
Has Abstractpub_date
2008-04-01 00:00:00pages
514-21issue
4eissn
0014-4894issn
1090-2449pii
S0014-4894(07)00297-4journal_volume
118pub_type
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