Abstract:
:Snails from a B. glabrata stock, selected for nonsusceptibility to the NMRI strain of S. mansoni, exhibited unusual schistosome infections, with multiple sporocysts prominent in the head-foot (foot-sporocysts). When F1 progeny from numerous crosses between well-defined susceptible (S) and resistant (R) parental snails were exposed, 60% of the infected snails also exhibited this unusual phenotype. F1 progeny from S x S snail crosses developed normal infections. Foot-sporocysts usually developed much later than secondary sporocysts of normal infections and before 12 weeks postexposure the tissue reaction surrounding foot-sporocysts was less intense than reactions to sporocysts in other tissues of the body. Cercariae were seen emerging directly from foot-sporocysts. Infection of S x R hybrid progeny by three other strains of S. mansoni also resulted in the production of foot-sporocysts. Development of the foot-sporocyst infection phenotype in progeny from many snail crosses suggests that this phenotype is more common than previously recognized. Over 50% of the F1 progeny from S x R parental crosses developed patent infections, a fact relevant to the possible biological control of schistosomiasis by the introduction of refractory snails into endemic areas.
journal_name
Exp Parasitoljournal_title
Experimental parasitologyauthors
Lewis FA,Richards CS,Knight M,Cooper LA,Clark Bdoi
10.1006/expr.1993.1092subject
Has Abstractpub_date
1993-11-01 00:00:00pages
349-61issue
3eissn
0014-4894issn
1090-2449pii
S0014-4894(83)71092-1journal_volume
77pub_type
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