Schistosoma mansoni: analysis of an unusual infection phenotype in the intermediate host snail Biomphalaria glabrata.

Abstract:

:Snails from a B. glabrata stock, selected for nonsusceptibility to the NMRI strain of S. mansoni, exhibited unusual schistosome infections, with multiple sporocysts prominent in the head-foot (foot-sporocysts). When F1 progeny from numerous crosses between well-defined susceptible (S) and resistant (R) parental snails were exposed, 60% of the infected snails also exhibited this unusual phenotype. F1 progeny from S x S snail crosses developed normal infections. Foot-sporocysts usually developed much later than secondary sporocysts of normal infections and before 12 weeks postexposure the tissue reaction surrounding foot-sporocysts was less intense than reactions to sporocysts in other tissues of the body. Cercariae were seen emerging directly from foot-sporocysts. Infection of S x R hybrid progeny by three other strains of S. mansoni also resulted in the production of foot-sporocysts. Development of the foot-sporocyst infection phenotype in progeny from many snail crosses suggests that this phenotype is more common than previously recognized. Over 50% of the F1 progeny from S x R parental crosses developed patent infections, a fact relevant to the possible biological control of schistosomiasis by the introduction of refractory snails into endemic areas.

journal_name

Exp Parasitol

authors

Lewis FA,Richards CS,Knight M,Cooper LA,Clark B

doi

10.1006/expr.1993.1092

subject

Has Abstract

pub_date

1993-11-01 00:00:00

pages

349-61

issue

3

eissn

0014-4894

issn

1090-2449

pii

S0014-4894(83)71092-1

journal_volume

77

pub_type

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