Echinococcus granulosus: induction of T-independent antibody response against protoscolex glycoconjugates in early experimental infection.

Abstract:

:In this work CD4-knockout mice were used as a model to analyse the role of CD4+ T cells in the antibody response against Echinococcus granulosus immunization or experimental infection. Results obtained with mice immunized with protoscolex antigens indicated that these contain T-independent antigens. After infection, CD4-knockout mice and C57Bl/6 mice showed similar titres of specific antibodies indicating that T-independent antibody production was quantitatively important in early infection. We have also identified an antigenic fraction from protoscoleces (E4+) which induces CD4 T cell independent antibody response in early stages of infection. In conclusion, the results presented here directly support the existence of T-independent immunogens in E. granulosus protoscoleces and suggest that T-independent antibody response may be quantitatively important in early infection.

journal_name

Exp Parasitol

authors

Baz A,Carol H,Fernández V,Mourglia-Ettlin G,Nieto A,Orn A,Dematteis S

doi

10.1016/j.exppara.2008.04.024

subject

Has Abstract

pub_date

2008-08-01 00:00:00

pages

460-6

issue

4

eissn

0014-4894

issn

1090-2449

pii

S0014-4894(08)00126-4

journal_volume

119

pub_type

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