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Toxoplasma gondii: in vitro and in vivo activities of the hydroxynaphthoquinone 2-hydroxy-3-(1'-propen-3-phenyl)-1,4-naphthoquinone alone or combined with sulfadiazine.

Abstract：

:The compound 2-hydroxy-3-(1'-propen-3-phenyl)-1,4-naphthoquinone (PHNQ6) was evaluated for activity against Toxoplasma gondii, alone or combined with sulfadiazine. Treatment with PHNQ6 combined with sulfadiazine protected at least 70 and 90% of mice infected with RH and EGS strains, respectively. Mice were treated with PHNQ6 (50 mg/kg/day) alone or combined with sulfadiazine (40 mg/L) 30 days after infection with P strain. The number of brain cysts was lower in mice treated with PHNQ6 alone or combined with sulfadiazine compared to that in control mice. Degenerated bradyzoites were observed in animals treated with PHNQ6. Infectivity of bradyzoites treated with PHNQ6 alone or combined with sulfadiazine was inhibited after in vitro incubation.

journal_name

Exp Parasitol

journal_title

Experimental parasitology

authors

Ferreira RA,Oliveira AB,Ribeiro MF,Tafuri WL,Vitor RW

doi

10.1016/j.exppara.2005.12.006

keywords:

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

125-9

issue

2

eissn

0014-4894

issn

1090-2449

pii

S0014-4894(05)00322-X

journal_volume

113

pub_type

杂志文章

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