Plasmodium falciparum: naturally occurring rabbit immunoglobulins recognize human band 3 peptide motifs and malaria-infected red cells.


:The reactivity to overlapping decapeptides based on sequences of human band 3 protein was determined for 24 rabbit serum samples. A high percentage of the sera recognized sequences of amino acid 650-670, as well as several other sequences representing putative exofacial regions of the band 3 protein. When sera were used to stain immunofluorescently human erythrocytes, some of which were infected with P. falciparum, those samples that predominantly reacted with amino acids 650-670 stained P. falciparum-infected red cells, whereas those that reacted with other regions of band 3 stained all erythrocytes. A positive correlation was found between anti-band 3 reactivity and the capacity of a serum to inhibit the cytoadherence of P. falciparum-infected erythrocytes to C32 amelanotic melanoma cells. Also, some rabbit sera immunoprecipitated a high-molecular-weight protein from extracts of surface iodinated P. falciparum-infected red cells.


Exp Parasitol


Crandall I,Guthrie N,Sherman IW




Has Abstract


1996-01-01 00:00:00














  • Trypanosoma cruzi (Kinetoplastida Trypanosomatidae): ecology of the transmission cycle in the wild environment of the Andean valley of Cochabamba, Bolivia.

    abstract::An active Trypanosoma cruzi transmission cycle maintained by wild rodents in the Andean valleys of Cochabamba Bolivia is described. Wild and domestic Triatoma infestans with 60% infection with T. cruzi were found and was evidenced in 47.5% (rodents) and 26.7% (marsupial) by parasitological and/or serologycal methods. ...

    journal_title:Experimental parasitology

    pub_type: 杂志文章


    authors: Cortez MR,Pinho AP,Cuervo P,Alfaro F,Solano M,Xavier SC,D'Andrea PS,Fernandes O,Torrico F,Noireau F,Jansen AM

    更新日期:2006-12-01 00:00:00

  • Vaccination of sheep with purified cysteine proteinases of Fasciola hepatica decreases worm fecundity.

    abstract::There has been some evidence from several parasite systems that proteinases might have potential as protective antigens against parasitic infection. A cysteine proteinase complex identified in the regurgitant of adult F. hepatica was examined in this context. The thiol-cathepsin-related proteinases of M(r) 28,000 were...

    journal_title:Experimental parasitology

    pub_type: 杂志文章


    authors: Wijffels GL,Salvatore L,Dosen M,Waddington J,Wilson L,Thompson C,Campbell N,Sexton J,Wicker J,Bowen F

    更新日期:1994-03-01 00:00:00

  • The cytostome of Trypanosoma cruzi epimastigotes is associated with the flagellar complex.

    abstract::Okuda, K., Esteva, M., Segura, E. L., and Bijovsky, A. T. 1999. The cytostome of Trypanosoma cruzi epimastigotes is associated with the flagellar complex. Experimental Parasitology 92, 223-231. Proliferative forms of Trypanosoma cruzi, amastigotes and epimastigotes, have a cytostome, a specialized structure formed by ...

    journal_title:Experimental parasitology

    pub_type: 杂志文章


    authors: Okuda K,Esteva M,Segura EL,Bijovsy AT

    更新日期:1999-08-01 00:00:00

  • Entamoeba histolytica: cytopathogenicity and lectin activity of avirulent mutants.

    abstract::Three clones of Entamoeba histolytica (L-6, C93, C919) were isolated by mutagenesis with ethyl methanesulfonate from the axenic strain HM1:IMSS and were studied for adherence, cytolytic, and soluble galactose inhibitable lectin activity. Avirulent clones adhered to and killed fewer Chinese hamster ovary cells than HM1...

    journal_title:Experimental parasitology

    pub_type: 杂志文章


    authors: Orozco E,Rodriquez MA,Murphy CF,Salata RA,Petri WA,Smith RD,Ravdin JI

    更新日期:1987-04-01 00:00:00

  • Glucose-6-phosphate dehydrogenase from Plasmodium berghei: kinetic and electrophoretic characterization.

    abstract::Evidence is given for the existence of a parasite-specific glucose-6-phosphate dehydrogenase (G6PD) in Plasmodium berghei by characterization of its kinetic and electrophoretic properties. From infected rat erythrocytes the parasites were isolated, washed, and lysed. G6PD was purified by affinity chromatography with 2...

    journal_title:Experimental parasitology

    pub_type: 杂志文章


    authors: Buckwitz D,Jacobasch G,Kuckelkorn U,Plonka A,Gerth C

    更新日期:1990-04-01 00:00:00

  • Haemonchus contortus: evidence that the 3A3 collagen gene is a member of an evolutionarily conserved family of nematode cuticle collagens.

    abstract::Rabbit antisera were raised against an 18 amino acid-long peptide that corresponds to the predicted sequence of the carboxy-terminal, nontriple helical region of the Haemonchus contortus 3A3 collagen gene. This sequence is highly conserved and diagnostic for members of the col-l collagen family, which includes the 3A3...

    journal_title:Experimental parasitology

    pub_type: 杂志文章


    authors: Cox GN,Shamansky LM,Boisvenue RJ

    更新日期:1990-02-01 00:00:00

  • Evaluation of nephrotoxicity and ototoxicity of aminosidine (paromomycin)-allopurinol combination in dogs with leishmaniosis due to Leishmania infantum: A randomized, blinded, controlled study.

    abstract::Canine leishmaniosis due to Leishmania infantum is a widespread zoonotic disease. Although aminosidine can be an effective treatment, current therapeutic recommendations do not advocate its use, mainly due to concerns regarding the potential nephrotoxicity and ototoxicity of this drug. The aim of this randomized, blin...

    journal_title:Experimental parasitology

    pub_type: 杂志文章


    authors: Kasabalis D,Chatzis MK,Apostolidis K,Xenoulis PG,Buono A,Petanides T,Leontides LS,Polizopoulou ZS,Steiner JM,Suchodolski JS,Saridomichelakis MN

    更新日期:2019-11-01 00:00:00

  • Plasmodium falciparum: D260, an intraerythrocytic parasite protein, is a member of the glutamic acid dipeptide-repeat family of proteins.

    abstract::Members of a serologically cross-reacting family of proteins including Ag332 and Pf11.1, megadalton proteins of schizont-infected red blood cells, and gametocytes, respectively, and Pf155-RESA, a 155-kDa protein of ring-infected red blood cells, have been reported to share amino acid repeat sequences. These repeats ar...

    journal_title:Experimental parasitology

    pub_type: 杂志文章


    authors: Barnes DA,Wollish W,Nelson RG,Leech JH,Petersen C

    更新日期:1995-08-01 00:00:00

  • Toxoplasma gondii: cloning, expression and immunoreactivity of recombinant ROP5 and ROP18 antigens.

    abstract::Early diagnosis and determining the infective stage are critical for effective therapy of toxoplasmosis. Owing to the progress in biotechnology, commonly used native, non-standardized diagnostic antigens should be replaced by genetically engineered antigens. The recombinant proteins are also promising components of su...

    journal_title:Experimental parasitology

    pub_type: 杂志文章


    authors: Grzybowski MM,Dziadek B,Dziadek J,Gatkowska J,Dzitko K,Długońska H

    更新日期:2015-03-01 00:00:00

  • Acanthamoeba spp.: in vitro effects of clinical isolates on murine macrophages, osteosarcoma and HeLa cells.

    abstract::Three different cell lines (murine macrophages, HeLa and osteosarcoma cells) were assayed in order to check for the manifestation of the cytopathic effects of three strains of Acanthamoeba recently isolated in our laboratory from contact lens cases: CLC-16, CLC-41.r and CLC-51-l. Adhesion and cytotoxicity assays were ...

    journal_title:Experimental parasitology

    pub_type: 杂志文章


    authors: Martín-Navarro CM,Lorenzo-Morales J,Machín RP,López-Arencibia A,Valladares B,Piñero JE

    更新日期:2010-09-01 00:00:00

  • Cysticidal activity of extracts and isolated compounds from Teloxys graveolens: In vitro and in vivo studies.

    abstract::In the search of new alternatives for neurocysticercosis treatment, the cysticidal activity of organic extracts of Teloxys graveolens was evaluated. The in vitro activity of hexane, ethyl acetate and methanol extracts against Taenia crassiceps cysts was tested and the selectivity index relative to human fibroblasts wa...

    journal_title:Experimental parasitology

    pub_type: 杂志文章


    authors: Palomares-Alonso F,Rojas-Tomé IS,Juárez Rocha V,Palencia Hernández G,González-Maciel A,Ramos-Morales A,Santiago-Reyes R,González-Hernández IE,Jung-Cook H

    更新日期:2015-09-01 00:00:00

  • Trypanosoma cruzi: fusogenic ability of membranes from cultured epimastigotes in interaction with human syncytiotrophoblast.

    abstract::Trypanosoma cruzi epimastigotes cultured in vitro were disrupted by successive freezing and thawing and subsequent sonication. The total homogenate was fractionated by differential centrifugation to obtain an enriched plasma membrane fraction. The proteins of subcellular parasite fractions were labeled with 131I and t...

    journal_title:Experimental parasitology

    pub_type: 杂志文章


    authors: Calderon RO,de Fabro SP

    更新日期:1983-10-01 00:00:00

  • Trypanosoma cruzi: mixture of two populations can modify virulence and tissue tropism in rat.

    abstract::In rats, CL-Brener clone caused high mortality, severe acute myocarditis, and myositis that subsided completely in surviving animals. Accordingly, no parasite kDNA could be amplified in several organs after 4 months. The monoclonal JG strain caused null mortality, acute predominantly focal myocarditis, discrete and fo...

    journal_title:Experimental parasitology

    pub_type: 杂志文章


    authors: Franco DJ,Vago AR,Chiari E,Meira FC,Galvão LM,Machado CR

    更新日期:2003-05-01 00:00:00

  • Susceptibility of Brazilian isolates of Trypanosoma evansi to suramin sodium: test in experimentally infected mice.

    abstract::This study aimed to evaluate the susceptibility of Brazilian isolates of Trypanosoma evansi to suramin sodium. For this purpose, three isolates of T. evansi (LPV-2005, LPV-2009 and LPV-2010) and seventy mice were used, with the animals divided in 10 groups (A, B, C, D, E, F, G, H, I and J) with seven animals each grou...

    journal_title:Experimental parasitology

    pub_type: 杂志文章


    authors: Faccio L,Da Silva AS,Gressler LT,Tonin AA,Lazzarotto CR,Miletti LC,Monteiro SG

    更新日期:2013-07-01 00:00:00

  • Plasmodium berghei: is nitric oxide involved in the pathogenesis of mouse cerebral malaria?

    abstract::To analyze whether nitric oxide may be involved in the pathogenesis of the mouse cerebral malaria (CM), nitrate and nitrite were first measured in urines of Plasmodium species infected mice. The CM-susceptible CBA/J mice were infected with either Plasmodium berghei or Plasmodium chabaudi, and the CM-resistant BALB/c m...

    journal_title:Experimental parasitology

    pub_type: 杂志文章


    authors: Asensio VC,Oshima H,Falanga PB

    更新日期:1993-08-01 00:00:00

  • Theileria parva: expression of a sporozoite surface coat antigen.

    abstract::A monoclonal antibody specific for the Theileria parva sporozoite, which recognizes a determinant on the surface coat and blocks sporozoite infectivity, was used to investigate the presence of the determinant on other stages of the parasite lifecycle. Immunofluorescence techniques did not demonstrate this determinant ...

    journal_title:Experimental parasitology

    pub_type: 杂志文章


    authors: Dobbelaere DA,Webster P,Leitch BL,Voigt WP,Irvin AD

    更新日期:1985-08-01 00:00:00

  • Nematospiroides dubius: influence of adjuvants on immunity in mice vaccinated with antigens isolated by affinity chromatography from adult worms.

    abstract::Five adjuvants were examined for their ability to potentiate the immune response of mice to soluble antigens from adult Nematospiroides dubius prepared by affinity chromatography against antibodies from repeatedly infected mice as ligands (IMIgAg). Immunized mice were better protected against N. dubius by IMIgAg injec...

    journal_title:Experimental parasitology

    pub_type: 杂志文章


    authors: Monroy FG,Adams JH,Dobson C,East IJ

    更新日期:1989-01-01 00:00:00

  • Trypanostatic activity of geranylacetone: Mitigation of Trypanosoma congolense-associated pathological pertubations and insight into the mechanism of anaemia amelioration using in vitro and in silico models.

    abstract::Trypanosoma congolense is an important pathogen that wreaks havoc in the livestock industry of the African continent. This study evaluated the in vivo antitrypanosomal activity of geranylacetone and its ameliorative effect on the disease-induced anaemia and organ damages as well as its inhibitory effects against trypa...

    journal_title:Experimental parasitology

    pub_type: 杂志文章


    authors: Saad SB,Ibrahim MA,Jatau ID,Shuaibu MN

    更新日期:2019-06-01 00:00:00

  • Proteomic and immunomic analysis of Schistosoma mekongi egg proteins.

    abstract::Schistosomiasis remains a global health problem. In the Mekong river basin, approximately 80,000 people are at risk of infection by Schistosoma mekongi. The parasite's eggs become entrapped in the host's organs and induce massive inflammation, contributing to the pathogenesis of schistosomiasis. In addition, egg antig...

    journal_title:Experimental parasitology

    pub_type: 杂志文章


    authors: Thiangtrongjit T,Adisakwattana P,Limpanont Y,Dekumyoy P,Nuamtanong S,Chusongsang P,Chusongsang Y,Reamtong O

    更新日期:2018-08-01 00:00:00

  • Antifilarial activity of marine sponge Haliclona oculata against experimental Brugia malayi infection.

    abstract::The present study incorporates the findings on in vitro and in vivo antifilarial activity in the marine sponge, Haliclona oculata using an experimental rodent infection of human lymphatic filarial parasite, Brugia malayi. The in vitro antifilarial action was determined on both adult female worms as well as microfilari...

    journal_title:Experimental parasitology

    pub_type: 杂志文章


    authors: Gupta J,Misra S,Mishra SK,Srivastava S,Srivastava MN,Lakshmi V,Misra-Bhattacharya S

    更新日期:2012-04-01 00:00:00

  • Standardization of DNA extraction from sand flies: Application to genotyping by next generation sequencing.

    abstract::Standardization of the methods for extraction of DNA from sand flies is essential for obtaining high efficiency during subsequent molecular analyses, such as the new sequencing methods. Information obtained using these methods may contribute substantially to taxonomic, evolutionary, and eco-epidemiological studies. Th...

    journal_title:Experimental parasitology

    pub_type: 杂志文章


    authors: Casaril AE,de Oliveira LP,Alonso DP,de Oliveira EF,Gomes Barrios SP,de Oliveira Moura Infran J,Fernandes WS,Oshiro ET,Ferreira AMT,Ribolla PEM,de Oliveira AG

    更新日期:2017-06-01 00:00:00

  • Antileishmanial activity and mechanism of action from a purified fraction of Zingiber officinalis Roscoe against Leishmania amazonensis.

    abstract::In recent years, considerable attention has been given to identify new antileishmanial products derived from medicinal plants, although, to date, no new effective compound has been recently applied to treat leishmaniasis. In the present study, the antileishmanial activity of a water extract from Zingiber officinalis R...

    journal_title:Experimental parasitology

    pub_type: 杂志文章


    authors: Duarte MC,Tavares GS,Valadares DG,Lage DP,Ribeiro TG,Lage LM,Rodrigues MR,Faraco AA,Soto M,da Silva ES,Chávez Fumagalli MA,Tavares CA,Leite JP,Oliveira JS,Castilho RO,Coelho EA

    更新日期:2016-07-01 00:00:00

  • Proteolytic and nematicidal potential of the compost colonized by Hypsizygus marmoreus.

    abstract::Spent mushroom compost (SMC) is a residue generated in edible mushrooms production, such as Hypsizygus marmoreus. Its genome was recently sequenced, demonstrating cuticle-degrading protease genes. The present work aims to investigate the proteases from H. marmoreus spent mushroom compost (SMC) by verifying its action ...

    journal_title:Experimental parasitology

    pub_type: 杂志文章


    authors: Soares FEF,Nakajima VM,Sufiate BL,Satiro LAS,Gomes EH,Fróes FV,Sena FP,Braga FR,de Queiroz JH

    更新日期:2019-02-01 00:00:00

  • Schistosoma japonicum eggs modulate the activity of CD4+ CD25+ Tregs and prevent development of colitis in mice.

    abstract::Crohn's disease (CD) is considered to be caused by a disorder of the immune system and helminth infections may interact with development of the disease. We induced colitis in mice by trinitrobenzenesulfonic acid (TNBS) and observed the effects of intraperitoneally injected eggs of Schistosoma japonicum on the course o...

    journal_title:Experimental parasitology

    pub_type: 杂志文章


    authors: Mo HM,Liu WQ,Lei JH,Cheng YL,Wang CZ,Li YL

    更新日期:2007-08-01 00:00:00

  • Nitazoxanide anthelmintic activity against the enteral and parenteral phases of trichinellosis in experimentally infected rats.

    abstract::Most of the drugs used for the treatment of trichinellosis show a limited bioavailability and a high degree of resistance. Therefore, this study aimed to characterize the anthelmintic potential activity of nitazoxanide (NTZ) in a rat model of experimental trichinellosis. Animals were divided into three groups; group I...

    journal_title:Experimental parasitology

    pub_type: 杂志文章


    authors: Ashour DS,Abou Rayia DM,Saad AE,El-Bakary RH

    更新日期:2016-11-01 00:00:00

  • Leishmania major lipophosphoglycan: discrepancy in Toll-like receptor signaling.

    abstract::Lipophosphoglycan (LPG) is structurally characterized by a series of phosphoglycan repeat units. Cellular LPG, isolated from promastigotes, has a very similar structure to culture supernatant LPG, but differs in the average number of phosphorylated oligosaccharide repeat units and in glycan composition. Comparison of ...

    journal_title:Experimental parasitology

    pub_type: 杂志文章


    authors: Kavoosi G,Ardestani SK,Kariminia A,Alimohammadian MH

    更新日期:2010-02-01 00:00:00

  • Impaired clearance of primary but not secondary Brugia infections in IL-5 deficient mice.

    abstract::Eosinophilia in blood and tissues has been strongly associated with helminth infections for over a century. In vivo depletion of IL-5, a cytokine crucially involved in eosinophilopoiesis with an antibody or through genetic manipulation, reproducibly abrogates helminth-induced eosinophilia, but renders mice permissive ...

    journal_title:Experimental parasitology

    pub_type: 杂志文章


    authors: Ramalingam T,Ganley-Leal L,Porte P,Rajan TV

    更新日期:2003-10-01 00:00:00

  • Calpain-like: A Ca(2+) dependent cystein protease in Entamoeba histolytica cell death.

    abstract::Entamoeba histolytica programmed cell death (PCD) induced by G418 is characterized by the release of important amounts of intracellular calcium from reservoirs. Nevertheless, no typical caspases have been detected in the parasite, the PCD phenotype is inhibited by the cysteine protease inhibitor E-64. These results st...

    journal_title:Experimental parasitology

    pub_type: 杂志文章


    authors: Monroy VS,Flores OM,García CG,Maya YC,Fernández TD,Pérez Ishiwara DG

    更新日期:2015-12-01 00:00:00

  • Effect of ensilation of potato on viability of Taenia hydatigena eggs.

    abstract::A Taenia hydatigena model was used to assess the effect 0, 7, 14, 21, and 28 days of ensilation of minced potato on viability of tapeworm eggs. For infection of lambs, 2,000 T. hydatigena eggs were ensiled for 0, 7, 14, 21 and 28 days in minced potato at 22°C and fed to recently weaned lambs (29.9±0.76 kg). At slaught...

    journal_title:Experimental parasitology

    pub_type: 杂志文章


    authors: Buttar BS,Nelson ML,Busboom JR,Hancock DD,Walsh DB,Jasmer DP

    更新日期:2013-04-01 00:00:00

  • Steinernema feltiae: ammonia triggers the emergence of their infective juveniles.

    abstract::Entomopathogenic nematodes complete their life cycles inside dead insects. The emergence of new infective juveniles from the cadaver has been attributed (but never demonstrated) to food depletion or to the accumulation of metabolites from the breakdown of the host's tissues. Here we give evidence that emergence is tri...

    journal_title:Experimental parasitology

    pub_type: 杂志文章


    authors: San-Blas E,Gowen SR,Pembroke B

    更新日期:2008-05-01 00:00:00