Abstract:
:The Gal/GalNAc lectin gene of Entamoeba histolytica is a major amebic virulence protein responsible for interaction with host tissues. We investigated sequence differences in the Gal/GalNAc lectin heavy subunit in three isolates from Bangladesh and one isolate from Georgia, each of which was determined to be genetically distinct by SREHP AluI digestion. Interestingly, we observed only slight genetic diversity in the lectin gene as compared with the HM1:IMSS laboratory strain, originally a clinical isolate from Mexico. Genetic conservation of the Gal/GalNAc lectin between isolates may reflect that the lectin is under strong functional selection or possibly, that E. histolytica is a clonal population. Sequence conservation of the lectin indicates that immune responses against it should be cross-protective.
journal_name
Exp Parasitoljournal_title
Experimental parasitologyauthors
Beck DL,Tanyuksel M,Mackey AJ,Haque R,Trapaidze N,Pearson WR,Loftus B,Petri WAdoi
10.1016/s0014-4894(02)00113-3keywords:
subject
Has Abstractpub_date
2002-06-01 00:00:00pages
157-63issue
2-3eissn
0014-4894issn
1090-2449pii
S0014489402001133journal_volume
101pub_type
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