Abstract:
:To better control gastrointestinal nematode infections in humans and animals, it is important to understand the strategies used by these parasites to modulate the host immune system. In this regard, molecules released by parasites have been attributed crucially important roles in host-parasite negotiations. We characterized the excretory/secretory (E/S) microRNA (miRNA) and protein profiles from the mouse gastrointestinal nematode parasite Trichuris muris. Released miRNAs were subjected to miRNA sequencing and E/S proteins were analysed by mass spectrometry. Fourteen miRNAs were identified in T. muris exosome-like vesicles, as well as 73 proteins of nematode origin, 11 of which were unique to this study. Comparison with published nematode protein secretomes revealed high conservation at the functional level.
journal_name
Exp Parasitoljournal_title
Experimental parasitologyauthors
Tritten L,Tam M,Vargas M,Jardim A,Stevenson MM,Keiser J,Geary TGdoi
10.1016/j.exppara.2017.05.003subject
Has Abstractpub_date
2017-07-01 00:00:00pages
30-36eissn
0014-4894issn
1090-2449pii
S0014-4894(17)30079-6journal_volume
178pub_type
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