Excretory/secretory products from the gastrointestinal nematode Trichuris muris.

Abstract:

:To better control gastrointestinal nematode infections in humans and animals, it is important to understand the strategies used by these parasites to modulate the host immune system. In this regard, molecules released by parasites have been attributed crucially important roles in host-parasite negotiations. We characterized the excretory/secretory (E/S) microRNA (miRNA) and protein profiles from the mouse gastrointestinal nematode parasite Trichuris muris. Released miRNAs were subjected to miRNA sequencing and E/S proteins were analysed by mass spectrometry. Fourteen miRNAs were identified in T. muris exosome-like vesicles, as well as 73 proteins of nematode origin, 11 of which were unique to this study. Comparison with published nematode protein secretomes revealed high conservation at the functional level.

journal_name

Exp Parasitol

authors

Tritten L,Tam M,Vargas M,Jardim A,Stevenson MM,Keiser J,Geary TG

doi

10.1016/j.exppara.2017.05.003

subject

Has Abstract

pub_date

2017-07-01 00:00:00

pages

30-36

eissn

0014-4894

issn

1090-2449

pii

S0014-4894(17)30079-6

journal_volume

178

pub_type

杂志文章
  • Brugia pahangi: production of a monoclonal antibody reactive with the surface of infective larvae.

    abstract::Monoclonal antibodies against infective third-stage larvae (L3) of Brugia pahangi were generated from mice immunized with L3 antigens. The monoclonal antibodies were L3 stage-specific or stage-nonspecific. A BpG1 monoclonal antibody (IgG1 subclass) showing L3 stage-specificity was examined in detail. BpG1 recognized t...

    journal_title:Experimental parasitology

    pub_type: 杂志文章

    doi:10.1016/0014-4894(92)90130-3

    authors: Oikawa Y,Ikeda T,Horii Y,Fujita K,Tsukidate S

    更新日期:1992-08-01 00:00:00

  • Plasmodium coatneyi: differential clinical and immune responses of two populations of Macaca fascicularis from different origins.

    abstract::Two species of macaques, including two Macaca fascicularis from the Philippines, two M. fascicularis from Mauritius, and one Macaca mulatta, were experimentally infected with blood stages of Plasmodium coatneyi and followed during their clinical, parasitological, biological, and immunological evolution. Plasma cytokin...

    journal_title:Experimental parasitology

    pub_type: 杂志文章

    doi:10.1006/expr.1999.4342

    authors: Migot-Nabias F,Ollomo B,Dubreuil G,Morelli A,Domarle O,Nabias R,Georges AJ,Millet P

    更新日期:1999-01-01 00:00:00

  • Acanthamoeba castellanii: in vitro effects of selected biological, physical and chemical factors.

    abstract::Trophozoites and cysts of free-living Acanthamoeba castellanii present a serious risk to human health as causative agents of human diseases such as fatal granulomatous amoebic encephalitis and Acanthamoeba keratitis that is reported from various part of the world, also in Poland, with increasing frequency, particularl...

    journal_title:Experimental parasitology

    pub_type: 杂志文章

    doi:10.1016/j.exppara.2010.01.025

    authors: Chomicz L,Padzik M,Graczyk Z,Starosciak B,Graczyk TK,Naprawska A,Oledzka G,Szostakowska B

    更新日期:2010-09-01 00:00:00

  • The influence of natural rubber/Au nanoparticle membranes on the physiology of Leishmania brasiliensis.

    abstract::The development of nanotechnology has generated new means of disease diagnosis and treatment. Infectious diseases, including leishmaniasis, malaria, etc., have benefited from the advent of new nanomaterials and/or nanodevices capable of detecting specific antigens and antibodies with high specificity and low cost. In ...

    journal_title:Experimental parasitology

    pub_type: 杂志文章

    doi:10.1016/j.exppara.2011.10.015

    authors: Barboza-Filho CG,Cabrera FC,Dos Santos RJ,De Saja Saez JA,Job AE

    更新日期:2012-02-01 00:00:00

  • Plasmodium falciparum: immune pressure in Saimiri sciureus monkeys can select for a parasite population inducing a protective immunity that is not controlled by antibody.

    abstract::Protective immunity against a Plasmodium falciparum blood infection can be passively transferred by antibodies in humans and in the primate experimental malaria model Saimiri sciureus. We report here the emergence of a novel virulent parasite population after such passive transfer of hyperimmune serum in splenectomize...

    journal_title:Experimental parasitology

    pub_type: 杂志文章

    doi:10.1006/expr.1998.4318

    authors: Morales-Betoulle ME,de la Salmonière YO,Zwetyenga J,Le Scanf C,Jouin H,Michel JC

    更新日期:1998-09-01 00:00:00

  • A molecular tool for species identification and benzimidazole resistance diagnosis in larval communities of small ruminant parasites.

    abstract::This report describes a molecular method for determining in a first step the generic composition of a nematode community and in a second step, the resistance of each species to benzimidazole (BZ). We first established a polymerase chain reaction (PCR) linked to a restriction fragment length polymorphism strategy using...

    journal_title:Experimental parasitology

    pub_type: 杂志文章

    doi:10.1006/expr.2000.4542

    authors: Silvestre A,Humbert JF

    更新日期:2000-08-01 00:00:00

  • Gene silencing in root lesion nematodes (Pratylenchus spp.) significantly reduces reproduction in a plant host.

    abstract::Root lesion nematodes (RLNs, Pratylenchus species) are a group of economically important migratory endoparasitic plant pathogens that attack host roots of major crops such as wheat and sugarcane, and can reduce crop yields by 7-15%. Pratylenchus thornei and Pratylenchus zeae were treated with double stranded RNA (dsRN...

    journal_title:Experimental parasitology

    pub_type: 杂志文章

    doi:10.1016/j.exppara.2012.11.011

    authors: Tan JA,Jones MG,Fosu-Nyarko J

    更新日期:2013-02-01 00:00:00

  • Leishmania major and L. donovani: effects on proteolytic enzymes of Phlebotomus papatasi (Diptera, Psychodidae).

    abstract::Phlebotomus papatasi is susceptible to Leishmania major which it transmits in nature, but is resistant to L. donovani. The present study compares the effect of L. major and L. donovani on the proteolytic activity of P. papatasi gut enzymes. The experiments measured digestion of C14-labeled globin by gut homogenates of...

    journal_title:Experimental parasitology

    pub_type: 杂志文章

    doi:10.1016/0014-4894(86)90045-7

    authors: Schlein Y,Romano H

    更新日期:1986-12-01 00:00:00

  • Trypanosoma cruzi: peripheral blood monocytes and heart macrophages in the resistance to acute experimental infection in rats.

    abstract::The contribution of mononuclear phagocytes to host resistance against acute Chagas disease has been studied in vivo in a rat model inoculated with Trypanosoma cruzi, Y strain. Acute T. cruzi infection triggered a dramatic increase (937%) in peripheral blood monocyte number at day 12 of infection. At this point, histol...

    journal_title:Experimental parasitology

    pub_type: 杂志文章

    doi:10.1006/expr.2000.4576

    authors: Melo RC,Machado CR

    更新日期:2001-01-01 00:00:00

  • Steinernema feltiae: ammonia triggers the emergence of their infective juveniles.

    abstract::Entomopathogenic nematodes complete their life cycles inside dead insects. The emergence of new infective juveniles from the cadaver has been attributed (but never demonstrated) to food depletion or to the accumulation of metabolites from the breakdown of the host's tissues. Here we give evidence that emergence is tri...

    journal_title:Experimental parasitology

    pub_type: 杂志文章

    doi:10.1016/j.exppara.2008.01.008

    authors: San-Blas E,Gowen SR,Pembroke B

    更新日期:2008-05-01 00:00:00

  • Targeting epimastigotes of Trypanosoma cruzi with a peptide isolated from a phage display random library.

    abstract::Chagas disease, also known as American trypanosomiasis, is a potentially life-threatening illness caused by the protozoan parasite Trypanosoma cruzi, which is transmitted by insects of the family Reduviidae. Since conventional treatments with nitroheterocyclic drugs show serious adverse reactions and have questionable...

    journal_title:Experimental parasitology

    pub_type: 杂志文章

    doi:10.1016/j.exppara.2020.107830

    authors: Sáenz-Garcia JL,Yamanaka IB,Pacheco-Lugo LA,Miranda JS,Córneo ES,Machado-de-Ávila RA,De Moura JF,DaRocha WD

    更新日期:2020-03-01 00:00:00

  • Giardia lamblia: the roles of bile, lactic acid, and pH in the completion of the life cycle in vitro.

    abstract::Large numbers (10(4) to greater than 10(5)/ml) of Type I water-resistant Giardia lamblia cysts were produced in vitro under conditions that are characteristic of the human intestinal lumen. We define Type I cyst morphology as oval shaped, smooth, and refractile, with cyst wall, axostyle, and median body visible in rel...

    journal_title:Experimental parasitology

    pub_type: 杂志文章

    doi:10.1016/0014-4894(89)90185-9

    authors: Gillin FD,Boucher SE,Rossi SS,Reiner DS

    更新日期:1989-08-01 00:00:00

  • Propylene glycol and contact-lens solutions containing this diol induce pseudocyst formation in acanthamoebae.

    abstract::Propylene glycol used as an ophthalmic demulcent in certain contact-lens care systems has been included recently among factors responsible for increasing Acanthamoeba keratitis. In this study, we provide evidence that propylene glycol as well as examined contact-lens solutions containing it induce rapid differentiatio...

    journal_title:Experimental parasitology

    pub_type: 杂志文章

    doi:10.1016/j.exppara.2010.08.014

    authors: Kliescikova J,Kulda J,Nohynkova E

    更新日期:2011-01-01 00:00:00

  • Haemonchus contortus: in vitro and in vivo anthelmintic activity of aqueous and hydro-alcoholic extracts of Hedera helix.

    abstract::In vitro anthelmintic activity of crude extracts of the ripe fruits of Hedera helix was investigated on eggs and adult nematode parasites Haemonchus contortus. Aqueous extract of H. helix was also evaluated for in vivo anthelmintic activity at dose of 1.13 and 2.25 g/kg in sheep artificially infected with H. contortus...

    journal_title:Experimental parasitology

    pub_type: 杂志文章

    doi:10.1016/j.exppara.2007.01.019

    authors: Eguale T,Tilahun G,Debella A,Feleke A,Makonnen E

    更新日期:2007-08-01 00:00:00

  • The Apyrase gene of the vector mosquito, Aedes aegypti, is expressed specifically in the adult female salivary glands.

    abstract::The yellow fever mosquito, Aedes aegypti, expresses a gene, Apyrase (Apy), that encodes an ATP-diphosphohydrolase. The product of this gene is a secreted enzyme that facilitates hematophagy by preventing platelet aggregation in the host. Apy gene expression is limited to the cells of the distal-lateral and medial lobe...

    journal_title:Experimental parasitology

    pub_type: 杂志文章

    doi:10.1006/expr.1995.1114

    authors: Smartt CT,Kim AP,Grossman GL,James AA

    更新日期:1995-11-01 00:00:00

  • Biochemical, immunological, and biological characterization of Trypanosoma cruzi populations of the Andean north of Chile.

    abstract::Twenty-one Trypanosoma cruzi stocks isolated from Triatoma infestans and humans of the Chilean Andean highlands were studied at the genotypic level by schizodeme and molecular karyotype analyses, which allowed a clear distinction of the parasites from those hosts. A phenotypical characterization was performed by prote...

    journal_title:Experimental parasitology

    pub_type: 杂志文章

    doi:10.1006/expr.1995.1100

    authors: Gonzalez J,Muñoz S,Ortiz S,Anacona D,Salgado S,Galleguillos M,Neira I,Sagua H,Solari A

    更新日期:1995-08-01 00:00:00

  • Philasterides dicentrarchi, a histophagous ciliate causing scuticociliatosis in olive flounder, Philasterides dicentrarchi--histopathology investigations.

    abstract::Philasterides dicentrarchi is a histophagous scuticociliate infecting Korean olive flounder farms in Jeju Island, South Korea, where it causes significant economic losses. However, the route of entry of these parasites in olive flounder is currently unknown. In the present study, we attempted experimental infection wi...

    journal_title:Experimental parasitology

    pub_type: 杂志文章

    doi:10.1016/j.exppara.2011.12.007

    authors: Harikrishnan R,Jin CN,Kim JS,Balasundaram C,Heo MS

    更新日期:2012-03-01 00:00:00

  • Thermal properties of red blood cells infected by malaria parasites.

    abstract::Three membrane thermotropic transitions at 8, 20, and 40 degrees C have been detected in human red blood cells (RBC) by using spin-labeled stearic acids. Red blood cells infected in vitro by Plasmodium falciparum showed the disappearance of the 8 degrees C transition and a lowering of the 40 degrees C transition to 32...

    journal_title:Experimental parasitology

    pub_type: 杂志文章

    doi:10.1016/0014-4894(89)90073-8

    authors: Forte T,Roca L

    更新日期:1989-10-01 00:00:00

  • Recombinant vs native Anisakis haemoglobin (Ani s 13): Its appraisal as a new gold standard for the diagnosis of allergy.

    abstract::Recombinant allergens are currently the best option for serodiagnosis of human anisakiasis in terms of sensitivity and specificity. However, previous reports showed high rates of anisakiasis patients who were negative to Ani s 7 and especially to Ani s 1. Recently, Anisakis haemoglobin was described as a major allerge...

    journal_title:Experimental parasitology

    pub_type: 杂志文章

    doi:10.1016/j.exppara.2017.08.010

    authors: González-Fernández J,Rivas L,Luque-Ortega JR,Núñez-Ramírez R,Campioli P,Gárate T,Perteguer MJ,Daschner A,Cuéllar C

    更新日期:2017-10-01 00:00:00

  • Biological, biochemical and histopathological features related to parasitic castration of Biomphalaria glabrata infected by Schistosoma mansoni.

    abstract::Parasitic castration in the snail-trematode relationship can be understood as any change in the reproductive function of the snail that is due to interference by the developing larvae inside the snail that leads to the reduction or complete disruption of egg-laying activity. This study was designed to observe the para...

    journal_title:Experimental parasitology

    pub_type: 杂志文章

    doi:10.1016/j.exppara.2013.03.020

    authors: Faro MJ,Perazzini M,Corrêa Ldos R,Mello-Silva CC,Pinheiro J,Mota EM,de Souza S,de Andrade Z,Júnior AM

    更新日期:2013-06-01 00:00:00

  • Biochemical characterisation of the enzyme responsible for "activated L-serine sulphydrase" activity in nematodes.

    abstract::The biochemical properties of the enzyme responsible for nematode "activated L-serine sulphydrase" activity (L-cysteine + R-SH----cysteine thioether + H2S) have been investigated using primarily the gastro-intestinal nematodes Nippostrongylus brasiliensis and Haemonchus contortus. The activated L-serine sulphydrase en...

    journal_title:Experimental parasitology

    pub_type: 杂志文章

    doi:10.1016/0014-4894(92)90048-f

    authors: Walker J,Barrett J

    更新日期:1992-03-01 00:00:00

  • Oxidative stress associated with pathological lesions in the liver of rats experimentally infected by Fasciola hepatica.

    abstract::The aim of this study was to analyze the antioxidant status and oxidative profile in serum and liver of rats experimentally infected with Fasciola hepatica and its relationship with pathological findings. Twenty-four rats were divided into two groups: group A consisted of 12 healthy rats and group B of 12 rats infecte...

    journal_title:Experimental parasitology

    pub_type: 杂志文章

    doi:10.1016/j.exppara.2015.08.008

    authors: Bottari NB,Mendes RE,Lucca NJ,Schwertz CI,Henker LC,Olsson DC,Piva MM,Sangoi M,Campos LP,Moresco RN,Jaques JA,Da silva AS

    更新日期:2015-12-01 00:00:00

  • A confocal microscopy-based atlas of tissue architecture in the tapeworm Hymenolepis diminuta.

    abstract::Tapeworms are pervasive and globally distributed parasites that infect millions of humans and livestock every year, and are the causative agents of two of the 17 neglected tropical diseases prioritized by the World Health Organization. Studies of tapeworm biology and pathology are often encumbered by the complex life ...

    journal_title:Experimental parasitology

    pub_type: 杂志文章

    doi:10.1016/j.exppara.2015.05.015

    authors: Rozario T,Newmark PA

    更新日期:2015-11-01 00:00:00

  • Acanthamoeba culbertsoni: analysis of amoebic adhesion and invasion on extracellular matrix components collagen I and laminin-1.

    abstract::Acanthamoeba are free-living amoebae found in most environments that can cause brain and corneal infections. To infect humans, these pathogens must interact with host cells and the extracellular matrix (ECM). In order to define the mode by which amoebae recognize ECM components and process this recognition, we analyze...

    journal_title:Experimental parasitology

    pub_type: 杂志文章

    doi:10.1016/j.exppara.2009.08.004

    authors: Rocha-Azevedo Bd,Jamerson M,Cabral GA,Marciano-Cabral F

    更新日期:2010-09-01 00:00:00

  • Effects of Allium sativum on IFN-γ and IL4 concentrations in mice with cystic echinococcosis.

    abstract::The aim of the current investigation was to assess the impacts of methanolic extract of Allium sativum (MEAS) on IL-4 (a cytokine derived from Th2 cells) and IFN-ɣ (a cytokine derived from Th1 cells) levels in mice infected with Echinococcus granulosus. Sixty healthy BALB/c female mice were used in this study. Each an...

    journal_title:Experimental parasitology

    pub_type: 杂志文章

    doi:10.1016/j.exppara.2020.108042

    authors: Shirgholami Z,Borji H,Mohebalian H,Heidarpour M

    更新日期:2021-01-01 00:00:00

  • Cell death features induced in Leishmania major by 1,3,4-thiadiazole derivatives.

    abstract::Under a variety of stress conditions, Leishmania species display some morphological and biochemical features characteristic of mammalian programmed cell death or necrosis. Nitroheteroaryl-1,3,4-thiadiazoles induce cell death in Leishmania major (L. major). Putative mechanisms of action of these compounds were investig...

    journal_title:Experimental parasitology

    pub_type: 杂志文章

    doi:10.1016/j.exppara.2012.06.002

    authors: Ardestani SK,Poorrajab F,Razmi S,Foroumadi A,Ajdary S,Gharegozlou B,Behrouzi-Fardmoghadam M,Shafiee A

    更新日期:2012-10-01 00:00:00

  • Host species diversity and post-blood feeding carbohydrate availability enhance survival of females and fecundity in Aedes albopictus (Diptera: Culicidae).

    abstract::Aedes albopictus mosquito is an opportunistic blood feeder and has a broad host range. The feeding behavior and habits of this mosquito are liable to increase the transmission potential of arboviruses. The survival and fecundity in A. albopictus fed on different hosts and post-blood meal provision of sugar were invest...

    journal_title:Experimental parasitology

    pub_type: 杂志文章

    doi:10.1016/j.exppara.2008.01.007

    authors: Xue RD,Ali A,Barnard DR

    更新日期:2008-06-01 00:00:00

  • The therapeutic potential of phytol towards Trypanosoma congolense infection and the inhibitory effects against trypanosomal sialidase.

    abstract::The search for novel therapeutic candidates against animal trypanosomiasis is an ongoing scientific endevour because of the negative impacts of the disease to the African livestock industry. In this study, the in vivo therapeutic potentials of phytol toward Trypanosoma congolense infection and the inhibitory effects o...

    journal_title:Experimental parasitology

    pub_type: 杂志文章

    doi:10.1016/j.exppara.2020.107943

    authors: Saad SB,Ibrahim MA,Jatau ID,Shuaibu MN

    更新日期:2020-09-01 00:00:00

  • Toxoplasma gondii antigens: recovery analysis of tachyzoites cultivated in Vero cell maintained in serum free medium.

    abstract::Vero cells have been used successfully in Toxoplasma gondii maintenance. Medium supplementation for culture cells with fetal bovine serum is necessary for cellular growth. However, serum in these cultures presents disadvantages, such as the potential to induce hypersensitivity, variability of serum batches, possible p...

    journal_title:Experimental parasitology

    pub_type: 杂志文章

    doi:10.1016/j.exppara.2012.01.005

    authors: da Costa-Silva TA,da Silva Meira C,Frazzatti-Gallina N,Pereira-Chioccola VL

    更新日期:2012-04-01 00:00:00

  • Intranasal immunization with recombinant Trichinella spiralis serine protease elicits protective immunity in BALB/c mice.

    abstract::The aim of this study was to observe the intestinal mucosal/systemic responses triggered by intranasal vaccination using recombinant Trichinella spiralis serine protease (rTsSP) and its capacity to elicit immune protection against larva challenge in a murine model. rTsSP coupled with cholera toxin B subunit (CTB) was ...

    journal_title:Experimental parasitology

    pub_type: 杂志文章

    doi:10.1016/j.exppara.2019.04.006

    authors: Sun GG,Lei JJ,Ren HN,Zhang Y,Guo KX,Long SR,Liu RD,Jiang P,Wang ZQ,Cui J

    更新日期:2019-06-01 00:00:00