Abstract:
:It is generally accepted that a majority of individuals infected by Entamoeba histolytica do not develop symptomatic disease. However, the parasite and the host factors contributing to the development of the disease, remain undetermined. It is also unclear why certain individuals develop extra-intestinal amebiasis without exhibiting apparent intestinal symptoms. An outbreak of amebic liver abscess in Tbilisi, Georgia in 1998-1999 suggested that the causative E. histolytica strain had an unusual propensity for extra-intestinal spread. To correlate the genetic differences with pathogenic potential of the parasite, we have examined the SREHP gene polymorphisms among Georgian E. histolytica isolates. Comparison of polymorphic patterns revealed the presence of several different genotypes of E. histolytica, thus preventing an association of a single genotype with hepatic disease, but supporting the previous finding of extensive genetic diversity among E. histolytica isolates from the same geographic origin.
journal_name
Exp Parasitoljournal_title
Experimental parasitologyauthors
Simonishvili S,Tsanava S,Sanadze K,Chlikadze R,Miskalishvili A,Lomkatsi N,Imnadze P,Petri WA Jr,Trapaidze Ndoi
10.1016/j.exppara.2005.02.015keywords:
subject
Has Abstractpub_date
2005-07-01 00:00:00pages
313-7issue
3eissn
0014-4894issn
1090-2449pii
S0014-4894(05)00066-4journal_volume
110pub_type
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